Works matching DE "TDP-43 proteinopathies"

Results: 128

Limbic‐predominant age‐related TDP‐43 encephalopathy characterised by frontotemporal dementia‐like behavioural symptoms.

Published in:

2022

By:

Kobayashi, Ryota;
Kawakatsu, Shinobu;
Morioka, Daichi;
Hayashi, Hiroshi;
Utsunomiya, Aya;
Kabasawa, Takanobu;
Otani, Koichi

Publication type:

Case Study

Antibody against TDP-43 phosphorylated at serine 375 suggests conformational differences of TDP-43 aggregates among FTLD–TDP subtypes.

Published in:

Acta Neuropathologica, 2020, v. 140, n. 5, p. 645, doi. 10.1007/s00401-020-02207-w

By:

Neumann, Manuela;
Frick, Petra;
Paron, Francesca;
Kosten, Jonas;
Buratti, Emanuele;
Mackenzie, Ian R.

Publication type:

Article

Distinct clinicopathologic clusters of persons with TDP-43 proteinopathy.

Published in:

Acta Neuropathologica, 2020, v. 140, n. 5, p. 659, doi. 10.1007/s00401-020-02211-0

By:

Katsumata, Yuriko;
Abner, Erin L.;
Karanth, Shama;
Teylan, Merilee A.;
Mock, Charles N.;
Cykowski, Matthew D.;
Lee, Edward B.;
Boehme, Kevin L.;
Mukherjee, Shubhabrata;
Kauwe, John S. K.;
Kryscio, Richard J.;
Schmitt, Frederick A.;
Fardo, David W.;
Nelson, Peter T.

Publication type:

Article

Degeneration of the locus coeruleus is a common feature of tauopathies and distinct from TDP-43 proteinopathies in the frontotemporal lobar degeneration spectrum.

Published in:

Acta Neuropathologica, 2020, v. 140, n. 5, p. 675, doi. 10.1007/s00401-020-02210-1

By:

Ohm, Daniel T.;
Peterson, Claire;
Lobrovich, Rebecca;
Cousins, Katheryn A. Q.;
Gibbons, Garrett S.;
McMillan, Corey T.;
Wolk, David A.;
Van Deerlin, Vivianna;
Elman, Lauren;
Spindler, Meredith;
Deik, Andres;
Siderowf, Andrew;
Trojanowski, John Q.;
Lee, Edward B.;
Grossman, Murray;
Irwin, David J.

Publication type:

Article

Caspase-4 mediates cytoplasmic accumulation of TDP-43 in the primate brains.

Published in:

Acta Neuropathologica, 2019, v. 137, n. 6, p. 919, doi. 10.1007/s00401-019-01979-0

By:

Guo, Xiangyu;
Yan, Sen;
Yin, Peng;
Yang, Weili;
Li, Xiao-Jiang;
Yang, Su;
Zhao, Ting;
Li, Shihua;
Sun, Qiang;
Liu, Yunbo

Publication type:

Article

Genome-wide analyses as part of the international FTLD-TDP whole-genome sequencing consortium reveals novel disease risk factors and increases support for immune dysfunction in FTLD.

Published in:

Acta Neuropathologica, 2019, v. 137, n. 6, p. 879, doi. 10.1007/s00401-019-01962-9

By:

Pottier, Cyril;
Perkerson III, Ralph B.;
Baker, Matt;
van Blitterswijk, Marka;
DeJesus-Hernandez, Mariely;
Murray, Melissa E.;
Christopher, Elizabeth;
Vicente, Cristina T.;
Matchett, Billie;
Petrucelli, Leonard;
Dickson, Dennis W.;
Rademakers, Rosa;
Bieniek, Kevin F.;
Ertekin-Taner, Nilufer;
Rizzu, Patrizia;
Neumann, Manuela;
Heutink, Peter;
Synofzik, Matthis;
Wilke, Carlo;
Simon-Sanchez, Javier

Publication type:

Article

Expansion of the classification of FTLD-TDP: distinct pathology associated with rapidly progressive frontotemporal degeneration.

Published in:

Acta Neuropathologica, 2017, v. 134, n. 1, p. 65, doi. 10.1007/s00401-017-1679-9

By:

Lee, Edward;
Porta, Sílvia;
Michael Baer, G.;
Xu, Yan;
Suh, EunRan;
Kwong, Linda;
Elman, Lauren;
Grossman, Murray;
Lee, Virginia;
Irwin, David;
Deerlin, Vivianna;
Trojanowski, John

Publication type:

Article

Depletion of TDP-43 decreases fibril and plaque β-amyloid and exacerbates neurodegeneration in an Alzheimer's mouse model.

Published in:

Acta Neuropathologica, 2016, v. 132, n. 6, p. 859, doi. 10.1007/s00401-016-1637-y

By:

LaClair, Katherine;
Donde, Aneesh;
Ling, Jonathan;
Jeong, Yun;
Chhabra, Resham;
Martin, Lee;
Wong, Philip

Publication type:

Article

The phosphatase calcineurin regulates pathological TDP-43 phosphorylation.

Published in:

Acta Neuropathologica, 2016, v. 132, n. 4, p. 545, doi. 10.1007/s00401-016-1600-y

By:

Liachko, Nicole;
Saxton, Aleen;
McMillan, Pamela;
Strovas, Timothy;
Currey, Heather;
Taylor, Laura;
Wheeler, Jeanna;
Oblak, Adrian;
Ghetti, Bernardino;
Montine, Thomas;
Keene, C.;
Raskind, Murray;
Bird, Thomas;
Kraemer, Brian

Publication type:

Article

Functional recovery in new mouse models of ALS/FTLD after clearance of pathological cytoplasmic TDP-43.

Published in:

Acta Neuropathologica, 2015, v. 130, n. 5, p. 643, doi. 10.1007/s00401-015-1460-x

By:

Walker, Adam;
Spiller, Krista;
Ge, Guanghui;
Zheng, Allen;
Xu, Yan;
Zhou, Melissa;
Tripathy, Kalyan;
Kwong, Linda;
Trojanowski, John;
Lee, Virginia

Publication type:

Article

Hippocampal sclerosis in Lewy body disease is a TDP-43 proteinopathy similar to FTLD-TDP Type A.

Published in:

Acta Neuropathologica, 2015, v. 129, n. 1, p. 53, doi. 10.1007/s00401-014-1358-z

By:

Fujioka, Shinsuke;
Rutherford, Nicola;
Aoki, Naoya;
Murray, Melissa;
Ogaki, Kotaro;
Rademakers, Rosa;
Ross, Owen;
Dickson, Dennis

Publication type:

Article

Co-deposition of SOD1, TDP-43 and p62 proteinopathies in ALS: evidence for multifaceted pathways underlying neurodegeneration.

Published in:

Acta Neuropathologica Communications, 2022, v. 10, n. 1, p. 1, doi. 10.1186/s40478-022-01421-9

By:

Trist, Benjamin G.;
Fifita, Jennifer A.;
Hogan, Alison;
Grima, Natalie;
Smith, Bradley;
Troakes, Claire;
Vance, Caroline;
Shaw, Christopher;
Al-Sarraj, Safa;
Blair, Ian P.;
Double, Kay L.

Publication type:

Article

Intracellular dynamics of Ataxin-2 in the human brains with normal and frontotemporal lobar degeneration with TDP-43 inclusions.

Published in:

Acta Neuropathologica Communications, 2020, v. 8, n. 1, p. N.PAG, doi. 10.1186/s40478-020-01055-9

By:

Watanabe, Ryohei;
Higashi, Shinji;
Nonaka, Takashi;
Kawakami, Ito;
Oshima, Kenichi;
Niizato, Kazuhiro;
Akiyama, Haruhiko;
Yoshida, Mari;
Hasegawa, Masato;
Arai, Tetsuaki

Publication type:

Article

Prion-like Spreading of Disease in TDP-43 Proteinopathies.

Published in:

Brain Sciences (2076-3425), 2024, v. 14, n. 11, p. 1132, doi. 10.3390/brainsci14111132

By:

Pongrácová, Emma;
Buratti, Emanuele;
Romano, Maurizio

Publication type:

Article

Alterations in stress granule dynamics driven by TDP-43 and FUS: a link to pathological inclusions in ALS?

Published in:

Frontiers in Cellular Neuroscience, 2015, v. 9, p. 1, doi. 10.3389/fncel.2015.00423

By:

Aulas, Anaïs;
Velde, Christine Vande;
Di Angelantonio, Silvia;
Buratti, Emanuele

Publication type:

Article

Computational Insights of Unfolding of N-Terminal Domain of TDP-43 Reveal the Conformational Heterogeneity in the Unfolding Pathway.

Published in:

Frontiers in Molecular Neuroscience, 2022, v. 15, p. 1, doi. 10.3389/fnmol.2022.822863

By:

Li, Ruiting;
Singh, Ruhar;
Kashav, Tara;
Yang, ChunMin;
Sharma, Ravi Datta;
Lynn, Andrew M.;
Prasad, Rajendra;
Prakash, Amresh;
Kumar, Vijay

Publication type:

Article

TDP-43 and ER Stress in Neurodegeneration: Friends or Foes?

Published in:

Frontiers in Molecular Neuroscience, 2021, v. 14, p. 1, doi. 10.3389/fnmol.2021.772226

By:

de Mena, Lorena;
Lopez-Scarim, Joshua;
Rincon-Limas, Diego E.

Publication type:

Article

Divergent Histopathological Networks of Frontotemporal Degeneration Proteinopathy Subytpes.

Published in:

Journal of Neuroscience, 2022, v. 42, n. 18, p. 3868, doi. 10.1523/JNEUROSCI.2061-21.2022

By:

Min Chen;
Ohm, Daniel T.;
Phillips, Jeffrey S.;
McMillan, Corey T.;
Capp, Noah;
Peterson, Claire;
Xie, Emily;
Wolk, David A.;
Trojanowski, John Q.;
Lee, Edward B.;
Gee, James;
Grossman, Murray;
Irwin, David J.

Publication type:

Article

Molecular Mechanisms of Dementia.

Published in:

International Journal of Molecular Sciences, 2023, v. 24, n. 17, p. 13027, doi. 10.3390/ijms241713027

By:

Cantone, Mariagiovanna

Publication type:

Article

TDP-43 Proteinopathy and Tauopathy: Do They Have Pathomechanistic Links?

Published in:

International Journal of Molecular Sciences, 2022, v. 23, n. 24, p. 15755, doi. 10.3390/ijms232415755

By:

Riku, Yuichi;
Yoshida, Mari;
Iwasaki, Yasushi;
Sobue, Gen;
Katsuno, Masahisa;
Ishigaki, Shinsuke

Publication type:

Article

DCTN1 Binds to TDP-43 and Regulates TDP-43 Aggregation.

Published in:

International Journal of Molecular Sciences, 2021, v. 22, n. 8, p. 3985, doi. 10.3390/ijms22083985

By:

Deshimaru, Manami;
Kinoshita-Kawada, Mariko;
Kubota, Kaori;
Watanabe, Takuya;
Tanaka, Yasuyoshi;
Hirano, Saito;
Ishidate, Fumiyoshi;
Hiramoto, Masaki;
Ishikawa, Mitsuru;
Uehara, Yoshinari;
Okano, Hideyuki;
Hirose, Shinichi;
Fujioka, Shinsuke;
Iwasaki, Katsunori;
Yuasa-Kawada, Junichi;
Mishima, Takayasu;
Tsuboi, Yoshio

Publication type:

Article

Disease Animal Models of TDP-43 Proteinopathy and Their Pre-Clinical Applications.

Published in:

International Journal of Molecular Sciences, 2013, v. 14, n. 10, p. 20079, doi. 10.3390/ijms141020079

By:

Yu-Chih Liu;
Po-Min Chiang;
Kuen-Jer Tsai

Publication type:

Article

Quantitative analysis of cryptic splicing associated with TDP-43 depletion.

Published in:

BMC Medical Genomics, 2017, v. 10, p. 1, doi. 10.1186/s12920-017-0274-1

By:

Humphrey, Jack;
Emmett, Warren;
Fratta, Pietro;
Isaacs, Adrian M.;
Plagnol, Vincent

Publication type:

Article

Reversible Behavioral Phenotypes in a Conditional Mouse Model of TDP-43 Proteinopathies.

Published in:

Journal of Neuroscience, 2014, v. 34, n. 46, p. 15244, doi. 10.1523/JNEUROSCI.1918-14.2014

By:

Alfieri, Julio A.;
Pino, Natalia S.;
Igaz, Lionel M.

Publication type:

Article

Amyotrophic Lateral Sclerosis with Pallidonigroluysian Degeneration: A Clinicopathological Study.

Published in:

2020

By:

Ito, Junko;
Shimizu, Hiroshi;
Ohta, Kentaro;
Idezuka, Jiro;
Tanaka, Hajime;
Kondo, Hiroshi;
Nakajima, Takashi;
Takahashi, Hitoshi;
Akazawa, Kohei;
Onodera, Osamu;
Kakita, Akiyoshi

Publication type:

journal article

Repetitive Mild but Not Single Moderate Brain Trauma Is Associated with TAR DNA-Binding Protein 43 Mislocalization and Glial Activation in the Mouse Spinal Cord.

Published in:

Biomedicines, 2025, v. 13, n. 1, p. 218, doi. 10.3390/biomedicines13010218

By:

Janković, Tamara;
Rajič Bumber, Jelena;
Gržeta Krpan, Nika;
Dolenec, Petra;
Jaeger, Marc;
Kriz, Jasna;
Župan, Gordana;
Pilipović, Kristina

Publication type:

Article

Mitochondrion-Dependent Cell Death in TDP-43 Proteinopathies.

Published in:

Biomedicines, 2021, v. 9, n. 4, p. 376, doi. 10.3390/biomedicines9040376

By:

Lucini, Chantal B.;
Braun, Ralf J.

Publication type:

Article

Progression of motor neuron disease is accelerated and the ability to recover is compromised with advanced age in rNLS8 mice.

Published in:

Acta Neuropathologica Communications, 2016, v. 4, p. 1, doi. 10.1186/s40478-016-0377-5

By:

Spiller, Krista J.;
Restrepo, Clark R.;
Khan, Tahiyana;
Stieber, Anna M.;
Kwong, Linda K.;
Trojanowski, John Q.;
Lee, Virginia M. -Y.

Publication type:

Article

Pathological tau deposition in Motor Neurone Disease and frontotemporal lobar degeneration associated with TDP-43 proteinopathy.

Published in:

Acta Neuropathologica Communications, 2016, v. 4, p. 1, doi. 10.1186/s40478-016-0301-z

By:

Behrouzi, Roya;
Xiawei Liu;
Dongyue Wu;
Robinson, Andrew C.;
Tanaguchi-Watanabe, Sayuri;
Rollinson, Sara;
Jing Shi;
Jinzhou Tian;
Hamdalla, Hisham H. M.;
Ealing, John;
Richardson, Anna;
Jones, Matthew;
Pickering-Brown, Stuart;
Davidson, Yvonne S.;
Strong, Michael J.;
Masato Hasegawa;
Snowden, Julie S.;
Mann, David M. A.

Publication type:

Article

Semantic and right temporal variant of FTD: Next generation sequencing genetic analysis on a single-center cohort.

Published in:

Frontiers in Aging Neuroscience, 2022, v. 14, p. 1, doi. 10.3389/fnagi.2022.1085406

By:

Rossi, Giacomina;
Salvi, Erika;
Mehmeti, Elkadia;
Ricci, Martina;
Villa, Cristina;
Prioni, Sara;
Moda, Fabio;
Di Fede, Giuseppe;
Tiraboschi, Pietro;
Redaelli, Veronica;
Coppola, Cinzia;
Koch, Giacomo;
Canu, Elisa;
Filippi, Massimo;
Agosta, Federica;
Giaccone, Giorgio;
Caroppo, Paola

Publication type:

Article

TARDBP mutations in a cohort of Italian patients with Parkinson’s disease and atypical parkinsonisms.

Published in:

Frontiers in Aging Neuroscience, 2022, v. 14, p. 1, doi. 10.3389/fnagi.2022.1020948

By:

Tiloca, Cinzia;
Goldwurm, Stefano;
Calcagno, Narghes;
Verde, Federico;
Peverelli, Silvia;
Calini, Daniela;
Zecchinelli, Anna Lena;
Sangalli, Davide;
Ratti, Antonia;
Pezzoli, Gianni;
Silani, Vincenzo;
Ticozzi, Nicola

Publication type:

Article

Body Complexion and Circulating Lipids in the Risk of TDP-43 Related Disorders.

Published in:

Frontiers in Aging Neuroscience, 2022, v. 14, p. 1, doi. 10.3389/fnagi.2022.838141

By:

Esteban-García, Noelia;
Fernández-Beltrán, Luis C.;
Godoy-Corchuelo, Juan Miguel;
Ayala, Jose L.;
Matias-Guiu, Jordi A.;
Corrochano, Silvia

Publication type:

Article

Recent Developments in Positron Emission Tomography Tracers for Proteinopathies Imaging in Dementia.

Published in:

Frontiers in Aging Neuroscience, 2022, v. 13, p. 1, doi. 10.3389/fnagi.2021.751897

By:

Ni, Ruiqing;
Nitsch, Roger M.

Publication type:

Article

TDP-43 and NEAT long non-coding RNA: Roles in neurodegenerative disease.

Published in:

Frontiers in Cellular Neuroscience, 2022, v. 16, p. 1, doi. 10.3389/fncel.2022.954912

By:

Sekar, Durairaj;
Tusubira, Deusdedit;
Ross, Kehinde

Publication type:

Article

Dysregulation of Translation in TDP-43 Proteinopathies: Deficits in the RNA Supply Chain and Local Protein Production.

Published in:

Frontiers in Neuroscience, 2022, v. 16, p. 1, doi. 10.3389/fnins.2022.840357

By:

Bjork, Reed T.;
Mortimore, Nicholas P.;
Loganathan, Suvithanandhini;
Zarnescu, Daniela C.

Publication type:

Article

Targeting TDP-43 phosphorylation by Casein Kinase-1δ inhibitors: a novel strategy for the treatment of frontotemporal dementia.

Published in:

Molecular Neurodegeneration, 2016, v. 11, p. 1, doi. 10.1186/s13024-016-0102-7

By:

Alquezar, Carolina;
Salado, Irene G.;
de la Encarnación, Ana;
Pérez, Daniel I.;
Moreno, Fermín;
Gil, Carmen;
de Munain, Adolfo López;
Martínez, Ana;
Martín-Requero, Ángeles

Publication type:

Article

Erratum to: Endogenous TDP-43, but not FUS, contributes to stress granule assembly via G3BP.

Published in:: 2015
Publication type:: Correction Notice

Neuropathological assessments of the pathology in frontotemporal lobar degeneration with TDP43-positive inclusions: an inter-laboratory study by the BrainNet Europe consortium.

Published in:

Journal of Neural Transmission, 2015, v. 122, n. 7, p. 957, doi. 10.1007/s00702-014-1304-1

By:

Alafuzoff, Irina;
Pikkarainen, Maria;
Neumann, Manuela;
Arzberger, Thomas;
Al-Sarraj, Safa;
Bodi, Istvan;
Bogdanovic, Nenad;
Bugiani, Orso;
Ferrer, Isidro;
Gelpi, Ellen;
Gentleman, Stephen;
Giaccone, Giorgio;
Graeber, Manuel;
Hortobagyi, Tibor;
Ince, Paul;
Ironside, James;
Kavantzas, Nikolaos;
King, Andrew;
Korkolopoulou, Penelope;
Kovács, Gábor

Publication type:

Article

Erratum to: Neuropathological assessments of the pathology in frontotemporal lobar degeneration with TDP43-positive inclusions: an inter-laboratory study by the BrainNet Europe consortium.

Published in:

2015

By:

Alafuzoff, Irina;
Pikkarainen, Maria;
Neumann, Manuela;
Arzberger, Thomas;
Al-Sarraj, Safa;
Bodi, Istvan;
Bogdanovic, Nenad;
Bugiani, Orso;
Ferrer, Isidro;
Gelpi, Ellen;
Gentleman, Stephen;
Giaccone, Giorgio;
Graeber, Manuel;
Hortobagyi, Tibor;
Ince, Paul;
Ironside, James;
Kavantzas, Nikolaos;
King, Andrew;
Korkolopoulou, Penelope;
Kovács, Gábor

Publication type:

Erratum

TAR DNA-binding protein 43 and pathological subtype of Alzheimer's disease impact clinical features.

Published in:

2015

By:

Josephs, Keith A.;
Whitwell, Jennifer L.;
Tosakulwong, Nirubol;
Weigand, Stephen D.;
Murray, Melissa E.;
Liesinger, Amanda M.;
Petrucelli, Leonard;
Senjem, Matthew L.;
Ivnik, Robert J.;
Parisi, Joseph E.;
Petersen, Ronald C.;
Dickson, Dennis W.

Publication type:

journal article

Validating novel tau positron emission tomography tracer [F-18]-AV-1451 (T807) on postmortem brain tissue.

Published in:

2015

By:

Marquié, Marta;
Normandin, Marc D.;
Vanderburg, Charles R.;
Costantino, Isabel M.;
Bien, Elizabeth A.;
Rycyna, Lisa G.;
Klunk, William E.;
Mathis, Chester A.;
Ikonomovic, Milos D.;
Debnath, Manik L.;
Vasdev, Neil;
Dickerson, Bradford C.;
Gomperts, Stephen N.;
Growdon, John H.;
Johnson, Keith A.;
Frosch, Matthew P.;
Hyman, Bradley T.;
Gómez‐Isla, Teresa

Publication type:

journal article

Post-Mortem evaluation of amyloid-dopamine terminal positron emission tomography dementia classifications.

Published in:

2015

By:

Albin, Roger L.;
Fisher‐Hubbard, Amanda;
Shanmugasundaram, Krithika;
Koeppe, Robert A.;
Burke, James F.;
Camelo‐Piragua, Sandra;
Lieberman, Andrew P.;
Giordani, Bruno;
Frey, Kirk A.

Publication type:

journal article

Identification of genes associated with dissociation of cognitive performance and neuropathological burden: Multistep analysis of genetic, epigenetic, and transcriptional data.

Published in:

2017

By:

White, Charles C.;
Yang, Hyun-Sik;
Yu, Lei;
Chibnik, Lori B.;
Dawe, Robert J.;
Yang, Jingyun;
Klein, Hans-Ulrich;
Felsky, Daniel;
Ramos-Miguel, Alfredo;
Arfanakis, Konstantinos;
Honer, William G.;
Sperling, Reisa A.;
Schneider, Julie A.;
Bennett, David A.;
De Jager, Philip L.

Publication type:

journal article

Electrostatic Repulsion Governs TDP-43 C-terminal Domain Aggregation.

Published in:

2016

By:

Mompeán, Miguel;
Chakrabartty, Avijit;
Buratti, Emanuele;
Laurents, Douglas V.

Publication type:

Opinion

α-Synuclein emulsifies TDP-43 prion-like domain—RNA liquid droplets to promote heterotypic amyloid fibrils.

Published in:

Communications Biology, 2023, v. 6, n. 1, p. 1, doi. 10.1038/s42003-023-05608-1

By:

Dhakal, Shailendra;
Mondal, Malay;
Mirzazadeh, Azin;
Banerjee, Siddhartha;
Ghosh, Ayanjeet;
Rangachari, Vijayaraghavan

Publication type:

Article

Significance and limitation of the pathological classification of TDP-43 proteinopathy.

Published in:

Neuropathology, 2014, v. 34, n. 6, p. 578, doi. 10.1111/neup.12138

By:

Arai, Tetsuaki

Publication type:

Article

Theme 10 Therapeutic strategies.

Published in:: 2017
Publication type:: Abstract

Theme 6 Biomarkers.

Published in:: 2017
Publication type:: Abstract

Sessions 1 - 11.

Published in:: 2017
Publication type:: Proceeding

DNA strand breaks and TDP-43 mislocation are absent in the murine hSOD1<sup>G93A</sup> model of amyotrophic lateral sclerosis in vivo and in vitro.

Published in:

PLoS ONE, 2017, v. 12, n. 8, p. 1, doi. 10.1371/journal.pone.0183684

By:

Penndorf, Diane;
Tadić, Vedrana;
Witte, Otto W.;
Grosskreutz, Julian;
Kretz, Alexandra

Publication type:

Article