Works matching DE "SYNUCLEINS"

Results: 835

Targeting toxic forms of α-synuclein with immunotherapy could alter the progression of Parkinson's disease.

Published in:

Drugs & Therapy Perspectives, 2022, v. 38, n. 11, p. 467, doi. 10.1007/s40267-022-00950-6

By:

Paik, Julia

Publication type:

Article

Genetics of synucleins in neurodegenerative diseases.

Published in:

Acta Neuropathologica, 2021, v. 141, n. 4, p. 471, doi. 10.1007/s00401-020-02202-1

By:

Brás, José;
Gibbons, Elizabeth;
Guerreiro, Rita

Publication type:

Article

Multiple system atrophy prions retain strain specificity after serial propagation in two different Tg(SNCA*A53T) mouse lines.

Published in:

Acta Neuropathologica, 2019, v. 137, n. 3, p. 437, doi. 10.1007/s00401-019-01959-4

By:

Woerman, Amanda L.;
Oehler, Abby;
Kazmi, Sabeen A.;
Lee, Jisoo;
Halliday, Glenda M.;
Middleton, Lefkos T.;
Gentleman, Steve M.;
Mordes, Daniel A.;
Spina, Salvatore;
Grinberg, Lea T.;
Olson, Steven H.;
Prusiner, Stanley B.

Publication type:

Article

Regional levels of physiological α-synuclein are directly associated with Lewy body pathology.

Published in:

2018

By:

Erskine, Daniel;
Patterson, Lina;
Alexandris, Athanasios;
Hanson, Peter S.;
McKeith, Ian G.;
Attems, Johannes;
Morris, Christopher M.

Publication type:

Letter

Spread of aggregates after olfactory bulb injection of α-synuclein fibrils is associated with early neuronal loss and is reduced long term.

Published in:

Acta Neuropathologica, 2018, v. 135, n. 1, p. 65, doi. 10.1007/s00401-017-1792-9

By:

Rey, Nolwen L.;
George, Sonia;
Steiner, Jennifer A.;
Madaj, Zachary;
Luk, Kelvin C.;
Trojanowski, John Q.;
Lee, Virginia M.-Y.;
Brundin, Patrik

Publication type:

Article

Alpha-synuclein oligomers: a new hope.

Published in:

Acta Neuropathologica, 2017, v. 134, n. 6, p. 819, doi. 10.1007/s00401-017-1755-1

By:

Bengoa-Vergniory, Nora;
Roberts, Rosalind;
Wade-Martins, Richard;
Alegre-Abarrategui, Javier

Publication type:

Article

α-Synuclein transfer between neurons and astrocytes indicates that astrocytes play a role in degradation rather than in spreading.

Published in:

Acta Neuropathologica, 2017, v. 134, n. 5, p. 789, doi. 10.1007/s00401-017-1746-2

By:

Loria, Frida;
Vargas, Jessica;
Bousset, Luc;
Syan, Sylvie;
Salles, Audrey;
Melki, Ronald;
Zurzolo, Chiara

Publication type:

Article

The importance of developing strain-specific models of neurodegenerative disease.

Published in:

2017

By:

Woerman, Amanda

Publication type:

Letter

α-Synuclein binds to the ER-mitochondria tethering protein VAPB to disrupt Ca homeostasis and mitochondrial ATP production.

Published in:

Acta Neuropathologica, 2017, v. 134, n. 1, p. 129, doi. 10.1007/s00401-017-1704-z

By:

Paillusson, Sébastien;
Gomez-Suaga, Patricia;
Stoica, Radu;
Little, Daniel;
Gissen, Paul;
Devine, Michael;
Noble, Wendy;
Hanger, Diane;
Miller, Christopher

Publication type:

Article

Histones facilitate α-synuclein aggregation during neuronal apoptosis.

Published in:

Acta Neuropathologica, 2017, v. 133, n. 4, p. 547, doi. 10.1007/s00401-016-1660-z

By:

Jiang, Peizhou;
Gan, Ming;
Yen, Shu-Hui;
McLean, Pamela;
Dickson, Dennis

Publication type:

Article

Dermal phospho-alpha-synuclein deposits confirm REM sleep behaviour disorder as prodromal Parkinson's disease.

Published in:

Acta Neuropathologica, 2017, v. 133, n. 4, p. 535, doi. 10.1007/s00401-017-1684-z

By:

Doppler, Kathrin;
Jentschke, Hanna-Maria;
Schulmeyer, Lena;
Vadasz, David;
Janzen, Annette;
Luster, Markus;
Höffken, Helmut;
Mayer, Geert;
Brumberg, Joachim;
Booij, Jan;
Musacchio, Thomas;
Klebe, Stephan;
Sittig-Wiegand, Elisabeth;
Volkmann, Jens;
Sommer, Claudia;
Oertel, Wolfgang

Publication type:

Article

Brain-to-stomach transfer of α-synuclein via vagal preganglionic projections.

Published in:

Acta Neuropathologica, 2017, v. 133, n. 3, p. 381, doi. 10.1007/s00401-016-1661-y

By:

Ulusoy, Ayse;
Phillips, Robert;
Helwig, Michael;
Klinkenberg, Michael;
Powley, Terry;
Di Monte, Donato

Publication type:

Article

Mesenchymal stem cells enhance α-synuclein clearance via M2 microglia polarization in experimental and human parkinsonian disorder.

Published in:

Acta Neuropathologica, 2016, v. 132, n. 5, p. 685, doi. 10.1007/s00401-016-1605-6

By:

Park, Hyun;
Oh, Se;
Kim, Ha;
Jung, Yu;
Lee, Phil

Publication type:

Article

α-Synuclein-induced myelination deficit defines a novel interventional target for multiple system atrophy.

Published in:

Acta Neuropathologica, 2016, v. 132, n. 1, p. 59, doi. 10.1007/s00401-016-1572-y

By:

Ettle, Benjamin;
Kerman, Bilal;
Valera, Elvira;
Gillmann, Clarissa;
Schlachetzki, Johannes;
Reiprich, Simone;
Büttner, Christian;
Ekici, Arif;
Reis, André;
Wegner, Michael;
Bäuerle, Tobias;
Riemenschneider, Markus;
Masliah, Eliezer;
Gage, Fred;
Winkler, Jürgen

Publication type:

Article

Proaggregant nuclear factor(s) trigger rapid formation of α-synuclein aggregates in apoptotic neurons.

Published in:

Acta Neuropathologica, 2016, v. 132, n. 1, p. 77, doi. 10.1007/s00401-016-1542-4

By:

Jiang, Peizhou;
Gan, Ming;
Yen, Shu-Hui;
Moussaud, Simon;
McLean, Pamela;
Dickson, Dennis

Publication type:

Article

Pathological α-synuclein distribution in subjects with coincident Alzheimer's and Lewy body pathology.

Published in:

Acta Neuropathologica, 2016, v. 131, n. 3, p. 393, doi. 10.1007/s00401-015-1526-9

By:

Irwin, David;
Brettschneider, Johannes;
Arnold, Steven;
Toledo, Jon;
Gopal, Pallavi;
Raible, Kevin;
Sedor, Samantha;
Waits, Kayla;
Boluda, Susana;
Deerlin, Vivianna;
Lee, Edward;
Lee, Virginia;
Trojanowski, John;
Grossman, Murray;
Hurtig, Howard;
Duda, John;
Adler, Charles;
Beach, Thomas

Publication type:

Article

Non-prion-type transmission in A53T α-synuclein transgenic mice: a normal component of spinal homogenates from naïve non-transgenic mice induces robust α-synuclein pathology.

Published in:

2016

By:

Sacino, Amanda;
Ayers, Jacob;
Brooks, Mieu;
Chakrabarty, Paramita;
Hudson, Vincent;
Howard, Jasie;
Golde, Todd;
Giasson, Benoit;
Borchelt, David

Publication type:

Letter

Screening for α-synuclein immunoreactive neuronal inclusions in the hippocampus allows identification of atypical MSA (FTLD-synuclein).

Published in:

2015

By:

Rohan, Zdenek;
Rahimi, Jasmin;
Weis, Serge;
Kapas, Istvan;
Auff, Eduard;
Mitrovic, Nenad;
Liberski, Pawel;
Sikorska, Beata;
Matej, Radoslav;
Kovacs, Gabor

Publication type:

Letter

Extracellular vesicle sorting of α-Synuclein is regulated by sumoylation.

Published in:

Acta Neuropathologica, 2015, v. 129, n. 5, p. 695, doi. 10.1007/s00401-015-1408-1

By:

Kunadt, Marcel;
Eckermann, Katrin;
Stuendl, Anne;
Gong, Jing;
Russo, Belisa;
Strauss, Katrin;
Rai, Surya;
Kügler, Sebastian;
Falomir Lockhart, Lisandro;
Schwalbe, Martin;
Krumova, Petranka;
Oliveira, Luis;
Bähr, Mathias;
Möbius, Wiebke;
Levin, Johannes;
Giese, Armin;
Kruse, Niels;
Mollenhauer, Brit;
Geiss-Friedlander, Ruth;
Ludolph, Albert

Publication type:

Article

Erratum to: Amyloidogenic α-synuclein seeds do not invariably induce rapid, widespread pathology in mice.

Published in:

2014

By:

Sacino, Amanda;
Brooks, Mieu;
Thomas, Michael;
McKinney, Alex;
McGarvey, Nicholas;
Rutherford, Nicola;
Ceballos-Diaz, Carolina;
Robertson, Janice;
Golde, Todd;
Giasson, Benoit

Publication type:

Erratum

In vivo markers of Parkinson's disease and dementia with Lewy bodies: current value of the 5G4 α-synuclein antibody.

Published in:

2014

By:

Maetzler, Walter;
Pilotto, Andrea;
Apel, Anja;
Deuschle, Christian;
Kuebart, Gabriele;
Heinzel, Sebastian;
Liepelt-Scarfone, Inga;
Schulte, Claudia;
Reusch, Dorothee;
Schleicher, Erwin;
Rothfuss, Oliver;
Schneider, Anja;
Dodel, Richard;
Gasser, Thomas;
Berg, Daniela

Publication type:

Letter

Amyloidogenic α-synuclein seeds do not invariably induce rapid, widespread pathology in mice.

Published in:

Acta Neuropathologica, 2014, v. 127, n. 5, p. 645, doi. 10.1007/s00401-014-1268-0

By:

Sacino, Amanda;
Brooks, Mieu;
Thomas, Michael;
McKinney, Alex;
McGarvey, Nicholas;
Rutherford, Nicola;
Ceballos-Diaz, Carolina;
Robertson, Janice;
Golde, Todd;
Giasson, Benoit

Publication type:

Article

Accumulation of α-synuclein in the bowel of patients in the pre-clinical phase of Parkinson's disease.

Published in:

Acta Neuropathologica, 2014, v. 127, n. 2, p. 235, doi. 10.1007/s00401-013-1214-6

By:

Hilton, David;
Stephens, Madeleine;
Kirk, Leanne;
Edwards, Philip;
Potter, Ross;
Zajicek, John;
Broughton, Ellie;
Hagan, Hannah;
Carroll, Camille

Publication type:

Article

Transfer of human α-synuclein from the olfactory bulb to interconnected brain regions in mice.

Published in:

Acta Neuropathologica, 2013, v. 126, n. 4, p. 555, doi. 10.1007/s00401-013-1160-3

By:

Rey, Nolwen;
Petit, Geraldine;
Bousset, Luc;
Melki, Ronald;
Brundin, Patrik

Publication type:

Article

Sequence variants in eukaryotic translation initiation factor 4-gamma (eIF4G1) are associated with Lewy body dementia.

Published in:

Acta Neuropathologica, 2013, v. 125, n. 3, p. 425, doi. 10.1007/s00401-012-1059-4

By:

Fujioka, Shinsuke;
Sundal, Christina;
Strongosky, Audrey;
Castanedes, Monica;
Rademakers, Rosa;
Ross, Owen;
Vilariño-Güell, Carles;
Farrer, Matthew;
Wszolek, Zbigniew;
Dickson, Dennis

Publication type:

Article

The genetics and neuropathology of Parkinson's disease.

Published in:

Acta Neuropathologica, 2012, v. 124, n. 3, p. 325, doi. 10.1007/s00401-012-1013-5

By:

Houlden, Henry;
Singleton, Andrew

Publication type:

Article

Systemic proteasome inhibition triggers neurodegeneration in a transgenic mouse model expressing human α-synuclein under oligodendrocyte promoter: implications for multiple system atrophy.

Published in:

Acta Neuropathologica, 2012, v. 124, n. 1, p. 51, doi. 10.1007/s00401-012-0977-5

By:

Stefanova, Nadia;
Kaufmann, Walter;
Humpel, Christian;
Poewe, Werner;
Wenning, Gregor

Publication type:

Article

Nigrostriatal overabundance of α-synuclein leads to decreased vesicle density and deficits in dopamine release that correlate with reduced motor activity.

Published in:

Acta Neuropathologica, 2012, v. 123, n. 5, p. 653, doi. 10.1007/s00401-012-0963-y

By:

Gaugler, Meret;
Genc, Ozgur;
Bobela, Wojciech;
Mohanna, Safa;
Ardah, Mustafa;
El-Agnaf, Omar;
Cantoni, Marco;
Bensadoun, Jean-Charles;
Schneggenburger, Ralf;
Knott, Graham;
Aebischer, Patrick;
Schneider, Bernard

Publication type:

Article

Aggregation of αSynuclein promotes progressive in vivo neurotoxicity in adult rat dopaminergic neurons.

Published in:

Acta Neuropathologica, 2012, v. 123, n. 5, p. 671, doi. 10.1007/s00401-011-0926-8

By:

Taschenberger, Grit;
Garrido, Manuel;
Tereshchenko, Yuliya;
Bähr, Mathias;
Zweckstetter, Markus;
Kügler, Sebastian

Publication type:

Article

Structure of the toxic core of α-synuclein from invisible crystals.

Published in:

Nature, 2015, v. 525, n. 7570, p. 486, doi. 10.1038/nature15368

By:

Rodriguez, Jose A.;
Ivanova, Magdalena I.;
Sawaya, Michael R.;
Cascio, Duilio;
Reyes, Francis E.;
Shi, Dan;
Sangwan, Smriti;
Guenther, Elizabeth L.;
Johnson, Lisa M.;
Zhang, Meng;
Jiang, Lin;
Arbing, Mark A.;
Nannenga, Brent L.;
Hattne, Johan;
Whitelegge, Julian;
Brewster, Aaron S.;
Messerschmidt, Marc;
Boutet, Sébastien;
Sauter, Nicholas K.;
Gonen, Tamir

Publication type:

Article

α-Synuclein strains cause distinct synucleinopathies after local and systemic administration.

Published in:

Nature, 2015, v. 522, n. 7556, p. 340, doi. 10.1038/nature14547

By:

Peelaerts, W.;
Bousset, L.;
Van der Perren, A.;
Moskalyuk, A.;
Pulizzi, R.;
Giugliano, M.;
Van den Haute, C.;
Melki, R.;
Baekelandt, V.

Publication type:

Article

Properties of native brain α-synuclein.

Published in:

Nature, 2013, v. 498, n. 7453, p. E4, doi. 10.1038/nature12125

By:

Burré, Jacqueline;
Vivona, Sandro;
Diao, Jiajie;
Sharma, Manu;
Brunger, Axel T.;
Südhof, Thomas C.

Publication type:

Article

Bartels & Selkoe reply.

Published in:

Nature, 2013, v. 498, n. 7453, p. E6, doi. 10.1038/nature12126

By:

Bartels, Tim;
Selkoe, Dennis J.

Publication type:

Article

Parkinson's Disease Biomarkers: Resources for Discovery and Validation.

Published in:

Neuropsychopharmacology, 2014, v. 39, n. 1, p. 241, doi. 10.1038/npp.2013.246

By:

Frasier, Mark;
Kang, Un Jung

Publication type:

Article

Beyond the SNA RE: Munc18-1 chaperones α-synuclein.

Published in:

Journal of Cell Biology, 2016, v. 214, n. 6, p. 641, doi. 10.1083/jcb.201608060

By:

Deshpande, Mugdha;
Rodal, Avital A.

Publication type:

Article

LncRNA-UCA1 promotes PD development by upregulating SNCA.

Published in:

European Review for Medical & Pharmacological Sciences, 2018, v. 22, n. 22, p. 7908

By:

LU, M.;
SUN, W. L.;
SHEN, J.;
WEI, M.;
CHEN, B.;
QI, Y. J.;
XU, C. S.

Publication type:

Article

Disease-, region- and cell type specific diversity of α-synuclein carboxy terminal truncations in synucleinopathies.

Published in:

Acta Neuropathologica Communications, 2021, v. 9, n. 1, p. 1, doi. 10.1186/s40478-021-01242-2

By:

Hass, Ethan W.;
Sorrentino, Zachary A.;
Xia, Yuxing;
Lloyd, Grace M.;
Trojanowski, John Q.;
Prokop, Stefan;
Giasson, Benoit I.

Publication type:

Article

Synuclein Proteins in Cancer Development and Progression.

Published in:

Biomolecules (2218-273X), 2023, v. 13, n. 6, p. 980, doi. 10.3390/biom13060980

By:

Zanotti, Lucía C.;
Malizia, Florencia;
Cesatti Laluce, Nahuel;
Avila, Aylén;
Mamberto, Macarena;
Anselmino, Luciano E.;
Menacho-Márquez, Mauricio

Publication type:

Article

Age-Related Changes of the Synucleins Profile in the Mouse Retina.

Published in:

Biomolecules (2218-273X), 2023, v. 13, n. 1, p. 180, doi. 10.3390/biom13010180

By:

Dias, Sarah Batista;
de Lemos, Luísa;
Sousa, Luís;
Bitoque, Diogo B.;
Silva, Gabriela Araújo;
Seabra, Miguel C.;
Tenreiro, Sandra

Publication type:

Article

Intragenic β-synuclein rearrangements in malignancy.

Published in:

Frontiers in Oncology, 2023, p. 01, doi. 10.3389/fonc.2023.1167143

By:

Peifang Xiao;
Nan Chen;
Tingting Shao;
Xinni Bian;
Jie Miao;
Jiajia Zheng;
Xingping Lang;
Yiting Wang;
Xiaojun Chen;
Liqin Jin;
Shaoyan Hu;
Sheng Xiao

Publication type:

Article

Pre-aggregation kinetics and intermediates of α-synuclein monitored by the ESIPT probe 7MFE.

Published in:

European Biophysics Journal, 2018, v. 47, n. 4, p. 345, doi. 10.1007/s00249-017-1272-0

By:

Fauerbach, Jonathan A.;
Jovin, Thomas M.

Publication type:

Article

Relation of Enteric α-Synuclein to Gastrointestinal Dysfunction in Patients With Parkinson's Disease and in Neurologically Intact Subjects.

Published in:

Journal of Neurogastroenterology & Motility, 2018, v. 24, n. 3, p. 469, doi. 10.5056/jnm17141

By:

Hyo Jeong Lee;
Kee Wook Jung;
Sun Ju Chung;
Seung-Mo Hong;
Juyeon Kim;
Jeong Hoon Lee;
Sung Wook Hwang;
Ho-Sung Ryu;
Mi Jung Kim;
Ho-Su Lee;
Myeongsook Seo;
Sang Hyoung Park;
Dong-Hoon Yang;
Byong Duk Ye;
Jeong-Sik Byeon;
Jaewon Choe;
Hwoon-Yong Jung;
Suk-Kyun Yang;
Seung-Jae Myung

Publication type:

Article

Iron Deposition Leads to Neuronal α-Synuclein Pathology by Inducing Autophagy Dysfunction.

Published in:

Frontiers in Neurology, 2017, v. 7/8, p. 1, doi. 10.3389/fneur.2017.00001

By:

Wenbin Wan;
Lirong Jin;
Zigao Wang;
Lingyan Wang;
Guoqiang Fei;
Fanlong Ye;
Xiaoli Pan;
Changpeng Wang;
Chunjiu Zhong

Publication type:

Article

SNCA Is a Functionally Low-Expressed Gene in Lung Adenocarcinoma.

Published in:

Genes, 2018, v. 9, n. 1, p. 16, doi. 10.3390/genes9010016

By:

Yan, Yuanliang;
Xu, Zhijie;
Hu, Xiaofang;
Qian, Long;
Li, Zhi;
Zhou, Yangying;
Dai, Shuang;
Zeng, Shuangshuang;
Gong, Zhicheng

Publication type:

Article

Mitochondria and α-Synuclein: Friends or Foes in the Pathogenesis of Parkinson's Disease?

Published in:

Genes, 2017, v. 8, n. 12, p. 377, doi. 10.3390/genes8120377

By:

Faustini, Gaia;
Bono, Federica;
Valerio, Alessandra;
Pizzi, Marina;
Spano, Pier Franco;
Bellucci, Arianna

Publication type:

Article

A Dual GLP-1/GIP Receptor Agonist Is More Effective than Liraglutide in the A53T Mouse Model of Parkinson's Disease.

Published in:

Parkinson's Disease (20420080), 2023, p. 1, doi. 10.1155/2023/7427136

By:

Zhang, Zijuan;
Shi, Ming;
Li, Zhengmin;
Ling, Yuan;
Zhai, Luke;
Yuan, Ye;
Ma, He;
Hao, Li;
Li, Zhonghua;
Zhang, Zhenqiang;
Hölscher, Christian

Publication type:

Article

Mercury and Parkinson's Disease: Promising Leads, but Research Is Needed.

Published in:

Parkinson's Disease (20420080), 2023, p. 1, doi. 10.1155/2023/4709322

By:

Torrey, E. Fuller;
Simmons, Wendy

Publication type:

Article

Dyrk1a Phosphorylation of α-Synuclein Mediating Apoptosis of Dopaminergic Neurons in Parkinson's Disease.

Published in:

Parkinson's Disease (20420080), 2023, p. 1, doi. 10.1155/2023/8848642

By:

Yong, Yuxuan;
Wu, Qinfen;
Meng, Xinling;
Lu, Ranran;
Xia, Huan;
Pei, Feifei;
Yang, Xinling

Publication type:

Article

Copper(II) and the pathological H50Q α-synuclein mutant: Environment meets genetics.

Published in:

Communicative & Integrative Biology, 2017, v. 10, n. 1, p. N.PAG, doi. 10.1080/19420889.2016.1270484

By:

Villar-Piqué, Anna;
Rossetti, Giulia;
Ventura, Salvador;
Carloni, Paolo;
Fernández, Claudio O.;
Outeiro, Tiago Fleming

Publication type:

Article

α-Synuclein regulates the partitioning between tubulin dimers and microtubules at neuronal growth cone.

Published in:

Communicative & Integrative Biology, 2017, v. 10, n. 1, p. N.PAG, doi. 10.1080/19420889.2016.1267076

By:

Cartelli, Daniele;
Cappelletti, Graziella

Publication type:

Article