n-3 LC-PUFA supplementation: effects on infant and maternal outcomes.

Giuseppe, Rachele; Roggi, Carla; Cena, Hellas

Background: Long-chain polyunsaturated fatty acids (LC-PUFA), particularly docosahexaenoic acid (DHA) and arachidonic acid, are, respectively, n-3 and n-6 family members and play an important role in fetal and infant growth and development. Pregnancy and lactation impose special nutritional needs for the mother-fetus situation. Since the LC-PUFA required by the fetus is supplied by preferential placental transfer of preformed LC-PUFA rather than their precursor, it has been hypothesized that additional maternal supply of LC-PUFA, especially DHA, during pregnancy may improve maternal and infant outcomes. Aim: To summarize evidences of the effect of n-3 LC-PUFA intake during pregnancy and lactation on maternal and infant outcomes in order to offer a comprehensive view of this issue that should be useful for clinical practice. Results: Maternal n-3 LC-PUFA supplementation may reduce risk for early preterm birth >34 weeks and seems very promising for primary allergy prevention during childhood. On the contrary, there are not sufficient data proving that the consumption of oils rich in n-3 LC-PUFA during pregnancy optimizes child's visual and neurodevelopment and reduces the risk for preeclampsia and perinatal depression; the implications of these findings remain to be elucidated. Conclusion: The implications of n-3 LC-PUFA supplementation on fetal development, maternal outcomes and later infant growth is worth being elucidated and is promising in its potential for a positive impact on fetal and maternal outcomes.

ALLERGY prevention; PREECLAMPSIA prevention; POSTPARTUM depression; PREMATURE infants; IMMUNE system physiology; CHILD development; CHILD health services; CHILDREN'S health; CHILD nutrition; COGNITION in children; DIETARY supplements; GESTATIONAL age; INFANTS; INFANT development; INFANT nutrition; LACTATION; EVALUATION of medical care; MOTHERS; NUTRITIONAL requirements; OMEGA-3 fatty acids; PREGNANT women; VISION; WOMEN'S health; FETAL development; PREGNANCY; PREVENTION

European Journal of Nutrition, 2014, Vol 53, Issue 5, p1147

1436-6207

Academic Journal

10.1007/s00394-014-0660-9