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- Title
How does the genetic assassin select its neuronal target?
- Authors
Stevens, James; Fisher, Elizabeth; Mead, Simon
- Abstract
Through many different routes of analysis, including human familial studies and animal models, we are identifying an increasing number of genes that are causative for human neurodegenerative disease and are now in a position for many such disorders to dissect the molecular pathology that gives rise to neuronal death. Yet a paradox remains: The majority of the genes identified cause neurodegeneration in specific neuronal subtypes, but the genes themselves are ubiquitously expressed. Furthermore, the different mutations in the same gene may cause quite different types of neurodegeneration. Something in our understanding of neurodegenerative disease is clearly missing, and we refer to this as the phenomenon of 'neuronal targeting.' Here we discuss possible explanations for neuronal targeting, why specific neuronal subtypes are vulnerable to specific mutations in ubiquitously expressed genes.
- Subjects
NEURODEGENERATION; NEURONS; MOLECULAR pathology; DEGENERATION (Pathology); AMYOTROPHIC lateral sclerosis; SUPEROXIDE dismutase; DISEASES
- Publication
Mammalian Genome, 2011, Vol 22, Issue 3/4, p139
- ISSN
0938-8990
- Publication type
Academic Journal
- DOI
10.1007/s00335-011-9319-5