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- Title
Common variants of a urate-associated gene LRP2 are not associated with gout susceptibility.
- Authors
Nakayama, Akiyoshi; Matsuo, Hirotaka; Shimizu, Toru; Takada, Yuzo; Nakamura, Takahiro; Shimizu, Seiko; Chiba, Toshinori; Sakiyama, Masayuki; Naito, Mariko; Morita, Emi; Ichida, Kimiyoshi; Shinomiya, Nariyoshi
- Abstract
A recent genome-wide association study revealed that there is an association between serum uric acid (SUA) levels and rs2544390, a common variant in low-density lipoprotein-related protein 2 ( LRP2/ Megalin) gene. Two other variants of LRP2, rs2229268 and rs3755166, are also found to have associations with dyslipidemia and Alzheimer's disease, respectively, which also could have a relationship with SUA in human. Although no studies report that LRP2 transports urate, LRP2 is a multi-ligand receptor and expresses in many tissues including kidney, suggesting a direct and/or indirect relationship with gout. In the present study, we investigated the association between gout and these variants of LRP2 with 741 clinically diagnosed male gout patients and 1,302 controls. As a result, the three common LRP2 variants, rs2544390, rs2229268 and rs3755166, showed no association with gout ( P = 0.76, 0.55, and 0.22, respectively). Our study is the first to reveal that an SUA-related gene LRP2 is not involved in gout susceptibility.
- Subjects
SERUM; URIC acid; LIPOPROTEINS; PROTEINS; DYSLIPIDEMIA; ALZHEIMER'S disease
- Publication
Rheumatology International, 2014, Vol 34, Issue 4, p473
- ISSN
0172-8172
- Publication type
Academic Journal
- DOI
10.1007/s00296-013-2924-8