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- Title
Role of pregnane X receptor in chemotherapeutic treatment.
- Authors
Zhuo, Wei; Hu, Lei; Lv, Jinfeng; Wang, Hongbing; Zhou, Honghao; Fan, Lan
- Abstract
Pregnane X receptor (PXR) is a member of the nuclear receptor superfamily that differently expresses not only in human normal tissues but also in numerous types of human cancers. PXR can be activated by many endogenous substances and exogenous chemicals, and thus affects chemotherapeutic effects and intervenes drug-drug interactions by regulating its target genes involving drug metabolism and transportation, cell proliferation and apoptosis, and modulating endobiotic homeostasis. Tissue and context-specific regulation of PXR contributes to diverse effects in the treatment for numerous cancers. Genetic variants of PXR lead to intra- and inter-individual differences in the expression and inducibility of PXR, resulting in different responses to chemotherapy in PXR-positive cancers. The purpose of this review is to summarize and discuss the role of PXR in the metabolism and clearance of anticancer drugs. It is also expected that this review will provide insights into PXR-mediated enhancement for chemotherapeutic treatment, prediction of drug-drug interactions and personalized medicine.
- Subjects
CANCER chemotherapy; STEROID receptor coactivators; NUCLEAR receptors (Biochemistry); DRUG interactions; DRUG metabolism; HOMEOSTASIS
- Publication
Cancer Chemotherapy & Pharmacology, 2014, Vol 74, Issue 2, p217
- ISSN
0344-5704
- Publication type
Academic Journal
- DOI
10.1007/s00280-014-2494-9