Works matching DE "THYMIDYLATE synthase"

Results: 412

Codelivery of apigenin, FdUMP and CD276 antibody synergistic inhibit colorectal cancer by ferroptosis-apoptosis-pyroptosis and CD276 blockade.

Published in:

Asian Journal of Pharmaceutical Sciences, 2025, v. 20, n. 2, p. 1, doi. 10.1016/j.ajps.2025.101016

By:

Weiran Cao;
Xue Zhang;
Jiaxuan Chen;
Lu Sun;
Huining He;
Fei Yu

Publication type:

Article

Exploring Protein Expression Profiles in Lung Cancer Insufficient Microwave Ablation: Implications for Recurrence.

Published in:

OncoTargets & Therapy, 2025, v. 18, p. 467, doi. 10.2147/OTT.S508577

By:

Yan, Peng;
Yuan, Ruimei;
Li, Zheng;
Sun, Meili

Publication type:

Article

Thymidylate synthase and thymidine phosphorylase as predictive markers of capecitabine monotherapy in patients with anthracycline- and taxane-pretreated metastatic breast cancer.

Published in:

Cancer Chemotherapy & Pharmacology, 2011, v. 68, n. 3, p. 743, doi. 10.1007/s00280-010-1545-0

By:

Lee, Su;
Choi, Yoon;
Park, Yeon;
Kim, Seung;
Cho, Eun;
Ahn, Jin;
Im, Young-Hyuck

Publication type:

Article

A phase-I trial of pemetrexed plus carboplatin in recurrent ovarian cancer.

Published in:

Cancer Chemotherapy & Pharmacology, 2010, v. 66, n. 5, p. 861, doi. 10.1007/s00280-009-1230-3

By:

Sehouli, Jalid;
Camara, Oumar;
Mahner, Sven;
Bauknecht, Thomas;
Lichtenegger, Werner;
Runnebaum, Ingo;
Look, Katherine;
Jaenicke, Fritz;
Oskay-Oezcelik, Guelten

Publication type:

Article

A phase I/II trial of vorinostat in combination with 5-fluorouracil in patients with metastatic colorectal cancer who previously failed 5-FU-based chemotherapy.

Published in:

2010

By:

Wilson, Peter M.;
El-Khoueiry, Anthony;
Iqbal, Syma;
Fazzone, William;
LaBonte, Melissa J.;
Groshen, Susan;
Dongyun Yang;
Danenberg, Kathy D.;
Cole, Sarah;
Kornacki, Margaret;
Ladner, Robert D.;
Lenz, Heinz-Josef

Publication type:

Report

Genetic Markers of Therapeutic Efficacy of Methotrexate in Patients with Psoriasis.

Published in:

Bulletin of Experimental Biology & Medicine, 2022, v. 172, n. 4, p. 460, doi. 10.1007/s10517-022-05413-6

By:

Voron'ko, O. E.;
Baskaev, K. K.;
Sobolev, V. V.;
Denisova, E. V.;
Korsunskaya, I. M.

Publication type:

Article

Basic biochemical characterization of cytosolic enzymes in thymidine nucleotide synthesis in adult rat tissues: implications for tissue specific mitochondrial DNA depletion and deoxynucleoside-based therapy for TK2-deficiency.

Published in:

BMC Molecular & Cell Biology, 2020, v. 21, n. 1, p. 1, doi. 10.1186/s12860-020-00272-3

By:

Wang, Liya;
Sun, Ren;
Eriksson, Staffan

Publication type:

Article

Synthesis, in-silico Studies and Evaluation of Anticancer Activity of Some Novel Benzothiazole Substituted 4-Thiazolidinones.

Published in:

Indian Journal of Pharmaceutical Education & Research, 2020, v. 54, n. 4, p. 1121, doi. 10.5530/ijper.54.4.208

By:

Shetty, Chaithra Raju;
Bhat, Katte Ishwar;
Kumar, Abhishek;
Kumar, Pankaj;
Krishnamurthy, Praveen Thaggikuppe;
Merugumolu, Vijay Kumar

Publication type:

Article

Colon Cancer Pharmacogenetics: A Narrative Review.

Published in:

Pharmacy, 2022, v. 10, n. 4, p. 95, doi. 10.3390/pharmacy10040095

By:

Alfaro Alfaro, Álvaro Esteban;
Murillo Castillo, Brayan;
Cordero García, Eugenia;
Tascón, Javier;
Morales, Ana I.

Publication type:

Article

Biomarker expression and druggable gene alterations for development of an appropriate therapeutic protocol for pulmonary adenosquamous carcinoma.

Published in:

Histopathology, 2015, v. 66, n. 7, p. 939, doi. 10.1111/his.12556

By:

Watanabe, Yukio;
Shiraishi, Kouya;
Takahashi, Fumiaki;
Yoshida, Akihiko;
Suzuki, Kenji;
Asamura, Hisao;
Takeuchi, Masahiro;
Furuta, Koh;
Tsuta, Koji

Publication type:

Article

Synthesis of a novel series of amino acid prodrugs based on tegafur and evaluation of their antitumor activity.

Published in:

Journal of Chinese Pharmaceutical Sciences, 2021, v. 30, n. 9, p. 743, doi. 10.5246/jcps.2021.09.062

By:

Shiqi Xu;
Liyan Zhu;
Chao Hao;
Wenqian Liu;
Chenglong Chen;
Yongyi Chen;
Aiqin Liu

Publication type:

Article

Polymorphisms in TYMS for Prediction of Capecitabine-Induced Hand-Foot Syndrome in Chinese Patients with Colorectal Cancer.

Published in:

Cancer Research & Treatment, 2021, v. 53, n. 3, p. 724, doi. 10.4143/crt.2020.457

By:

Si-Qi Dong;
Tong-Min Wang;
Jiang-Bo Zhang;
Yong-Qiao He;
Wen-Qiong Xue;
Zi-Yi Wu;
Da-Wei Yang;
Lian-Jing Cao;
Jing-Wen Huang;
Xi-Zhao Li;
Pei-Fen Zhang;
Xiao-Hui Zheng;
Wei-Hua Jia

Publication type:

Article

Phase II Study of Pemetrexed as a Salvage Chemotherapy for Thymidylate Synthase-Low Squamous Cell Lung Cancer.

Published in:

Cancer Research & Treatment, 2021, v. 53, n. 1, p. 87, doi. 10.4143/crt.2020.741

By:

Mihong Choi;
Heung Tae Kim;
Ji-Youn Han;
Geon Kook Lee;
Soo-Hyun Lee;
Kun Young Lim;
Jungnam Joo;
Hye Jin Won;
Jin Soo Lee;
Youngjoo Lee

Publication type:

Article

Nanoquinacrine sensitizes 5-FU-resistant cervical cancer stem-like cells by down-regulating Nectin-4 via ADAM-17 mediated NOTCH deregulation.

Published in:

Cellular Oncology (2211-3428), 2019, v. 42, n. 2, p. 157, doi. 10.1007/s13402-018-0417-1

By:

Nayak, Anmada;
Das, Sarita;
Nayak, Deepika;
Sethy, Chinmayee;
Narayan, Satya;
Kundu, Chanakya Nath

Publication type:

Article

TS gene polymorphisms are not good markers of response to 5-FU therapy in stage III colon cancer patients.

Published in:

Analytical Cellular Pathology: Cellular Oncology, 2010, v. 33, n. 1, p. 1, doi. 10.1155/2010/731873

By:

Fariña-Sarasqueta, A.;
Gosens, M. J. E. M.;
Moerland, E.;
van Lijnschoten, I.;
Lemmens, V. E. P. P.;
Slooter, G. D.;
Rutten, H. J. T.;
van den Brule, A. J. C.

Publication type:

Article

Thymidylate Synthase as a Predictive Biomarker for Pemetrexed Response in NSCLC.

Published in:

Lung Cancer International, 2013, p. 1, doi. 10.1155/2013/436409

By:

Bukhari, Ali A.;
Goudar, Ranjit K.

Publication type:

Article

Anticancer potential of novel 5-Fluorouracil co-crystals against MCF7 breast and SW480 colon cancer cell lines along with docking studies.

Published in:

Arabian Journal of Chemistry, 2022, v. 15, n. 12, p. N.PAG, doi. 10.1016/j.arabjc.2022.104299

By:

Jubeen, Farhat;
Ijaz, Sana;
Jabeen, Ishrat;
Aftab, Usman;
Mehdi, Wajeeha;
Altaf, Awais;
Alissa, Siham A.;
Al-Ghulikah, Hanan A.;
Ezzine, Safa;
Bejaoui, Imen;
Iqbal, Munawar

Publication type:

Article

Anticancer activity, spectroscopic and molecular docking of some new synthesized sugar hydrazones, Arylidene and α-Aminophosphonate derivatives.

Published in:

Arabian Journal of Chemistry, 2021, v. 14, n. 10, p. N.PAG, doi. 10.1016/j.arabjc.2021.103348

By:

Amer, Hamada H.;
Alotaibi, Saad H.;
Trawneh, Amer H.;
Metwaly, Ahmed M.;
Eissa, Ibrahim H.

Publication type:

Article

Combined gene deletion of dihydrofolate reductase-thymidylate synthase and pteridine reductase in Leishmania infantum.

Published in:

PLoS Neglected Tropical Diseases, 2021, v. 15, n. 4, p. 1, doi. 10.1371/journal.pntd.0009377

By:

Bhattacharya, Arijit;
Leprohon, Philippe;
Ouellette, Marc

Publication type:

Article

Association of thymidylate synthase gene 3'-untranslated region polymorphism with sensitivity of non-small cell lung cancer to pemetrexed treatment: TS gene polymorphism and pemetrexed sensitivity in NSCLC.

Published in:

Journal of Biomedical Science, 2013, v. 20, n. 1, p. 1, doi. 10.1186/1423-0127-20-5

By:

Xia Wang;
Yadi Wang;
Yue Wang;
Jian Cheng;
Yanyun Wang;
Minwen Ha

Publication type:

Article

Thymidylate synthase promotes esophageal squamous cell carcinoma growth by relieving oxidative stress through activating nuclear factor erythroid 2-related factor 2 expression.

Published in:

PLoS ONE, 2023, v. 18, n. 9, p. 1, doi. 10.1371/journal.pone.0290264

By:

Yang, Jian;
Zhang, Jingjing;
Chen, Jingtian;
Yang, Xiaolong;
Sun, Hui;
Zhao, Zhenxiang;
Zhou, Hui;
Shen, Hao

Publication type:

Article

Understanding the molecular mechanism of substrate channeling and domain communication in protozoal bifunctional TS-DHFR.

Published in:

PEDS: Protein Engineering, Design & Selection, 2017, v. 30, n. 3, p. 253, doi. 10.1093/protein/gzx004

By:

Anderson, Karen S.

Publication type:

Article

Design and characterization of a mutation outside the active site of human thymidylate synthase that affects ligand binding.

Published in:

PEDS: Protein Engineering, Design & Selection, 2010, v. 23, n. 2, p. 81, doi. 10.1093/protein/gzp075

By:

Cardinale, D.;
Salo-Ahen, O. M. H.;
Guaitoli, G.;
Ferrari, S.;
Venturelli, A.;
Franchini, S.;
Battini, R.;
Ponterini, G.;
Wade, R. C.;
Costi, M. P.

Publication type:

Article

Machine learning-based algorithm identifies key mitochondria-related genes in non-alcoholic steatohepatitis.

Published in:

Lipids in Health & Disease, 2024, v. 23, n. 1, p. 1, doi. 10.1186/s12944-024-02122-z

By:

Dai, Longfei;
Jiang, Renao;
Zhan, Zhicheng;
Zhang, Liangliang;
Qian, Yuyang;
Xu, Xinjian;
Yang, Wenqi;
Zhang, Zhen

Publication type:

Article

Changes in 5-Fluorouracil-induced external granular cell damage during the time-course of the developing cerebellum of infant rats.

Published in:

Journal of Toxicologic Pathology, 2022, v. 35, n. 4, p. 299, doi. 10.1293/tox.2022-0003

By:

Yuko Yamaguchi;
Tsubasa Saito;
Mizuho Takagi;
Tomomi Nakazawa;
Kazutoshi Tamura

Publication type:

Article

Uncovering cancer vulnerabilities by machine learning prediction of synthetic lethality.

Published in:

Molecular Cancer, 2021, v. 20, n. 1, p. 1, doi. 10.1186/s12943-021-01405-8

By:

Benfatto, Salvatore;
Serçin, Özdemirhan;
Dejure, Francesca R.;
Abdollahi, Amir;
Zenke, Frank T.;
Mardin, Balca R.

Publication type:

Article

Genome-wide regulation of KSHV RNA splicing by viral RNA-binding protein ORF57.

Published in:

PLoS Pathogens, 2022, v. 18, n. 7, p. 1, doi. 10.1371/journal.ppat.1010311

By:

Majerciak, Vladimir;
Alvarado-Hernandez, Beatriz;
Lobanov, Alexei;
Cam, Maggie;
Zheng, Zhi-Ming

Publication type:

Article

TYMS Knockdown Suppresses Cells Proliferation, Promotes Ferroptosis via Inhibits PI3K/Akt/mTOR Signaling Pathway Activation in Triple Negative Breast Cancer.

Published in:

Cell Biochemistry & Biophysics, 2024, v. 82, n. 3, p. 2717, doi. 10.1007/s12013-024-01388-5

By:

Wang, Lin;
Wu, Zheyi;
Wang, Yanyan;
Chen, Chunchun;
Li, Yulong;
Dong, Huiming;
Yao, Tingjing;
Jin, Gongsheng;
Wang, Zhenjie

Publication type:

Article

Relationship Between the DPD and TS mRNA Expression and the Response to S-1-Based Chemotherapy and Prognosis in Patients with Advanced Gastric Cancer.

Published in:

Cell Biochemistry & Biophysics, 2015, v. 71, n. 3, p. 1653, doi. 10.1007/s12013-014-0387-5

By:

Shen, Xiao-Ming;
Zhou, Chong;
Lian, Lian;
Li, Li-Qun;
Li, Wei;
Tao, Min

Publication type:

Article

Molecular dynamics and energetic perceptions of substrate recognition by thymidylate kinase.

Published in:

Journal of Thermal Analysis & Calorimetry, 2014, v. 115, n. 3, p. 2089, doi. 10.1007/s10973-013-3319-5

By:

Kandeel, Mahmoud;
Noguchi, Yoshihiro;
Oh-Hashi, Kentaro;
Kim, Hye-Sook;
Kitade, Yukio

Publication type:

Article

Selective anti-tumor activity of the novel fluoropyrimidine polymer F10 towards G48a orthotopic GBM tumors.

Published in:

Journal of Neuro-Oncology, 2014, v. 116, n. 3, p. 447, doi. 10.1007/s11060-013-1321-1

By:

Gmeiner, William;
Lema-Tome, Carla;
Gibo, Denise;
Jennings-Gee, Jamie;
Milligan, Carol;
Debinski, Waldemar

Publication type:

Article

Evolution of Metamorphism in Thymidylate Synthases Within the Primate Lineages.

Published in:

Journal of Molecular Evolution, 2011, v. 72, n. 3, p. 306, doi. 10.1007/s00239-011-9433-8

By:

BeiBei Luo;
Johnson, Saphronia R.;
Lebioda, Lukasz;
Berger, Sondra H.

Publication type:

Article

5-Aminouracil and other inhibitors of DNA replication induce biphasic interphase–mitotic cells in apical root meristems of Allium cepa.

Published in:

Plant Cell Reports, 2020, v. 39, n. 8, p. 1013, doi. 10.1007/s00299-020-02545-9

By:

Żabka, Aneta;
Winnicki, Konrad;
Polit, Justyna Teresa;
Bernasińska-Słomczewska, Joanna;
Maszewski, Janusz

Publication type:

Article

E2F1/TS Immunophenotype and Survival of Patients with Colorectal Cancer Treated with 5FU-Based Adjuvant Therapy.

Published in:

Pathology & Oncology Research, 2016, v. 22, n. 3, p. 601, doi. 10.1007/s12253-016-0043-z

By:

Sulzyc-Bielicka, Violetta;
Domagala, Pawel;
Bielicki, Dariusz;
Safranow, Krzysztof;
Rogowski, Wojciech;
Domagala, Wenancjusz

Publication type:

Article

Synthesis and Structure–Activity Relationship Studies of Pyrido [1,2- e ]Purine-2,4(1H,3H)-Dione Derivatives Targeting Flavin-Dependent Thymidylate Synthase in Mycobacterium tuberculosis.

Published in:

Molecules, 2022, v. 27, n. 19, p. 6216, doi. 10.3390/molecules27196216

By:

Biteau, Nicolas G.;
Roy, Vincent;
Nicolas, Cyril;
Becker, Hubert F.;
Lambry, Jean-Christophe;
Myllykallio, Hannu;
Agrofoglio, Luigi A.

Publication type:

Article

Synthesis of Sugar and Nucleoside Analogs and Evaluation of Their Anticancer and Analgesic Potentials.

Published in:

Molecules, 2022, v. 27, n. 11, p. 3499, doi. 10.3390/molecules27113499

By:

Hussain, Fahad;
Rahman, Fahad Imtiaz;
Saha, Poushali;
Mikami, Atsushi;
Osawa, Takashi;
Obika, Satoshi;
Rahman, S. M. Abdur

Publication type:

Article

Computational Identification of Druggable Bioactive Compounds from Catharanthus roseus and Avicennia marina against Colorectal Cancer by Targeting Thymidylate Synthase.

Published in:

Molecules, 2022, v. 27, n. 7, p. 2089, doi. 10.3390/molecules27072089

By:

Islam, Md Rashedul;
Awal, Md Abdul;
Khames, Ahmed;
Abourehab, Mohammad A. S.;
Samad, Abdus;
Hassan, Walid M. I.;
Alam, Rahat;
Osman, Osman I.;
Nur, Suza Mohammad;
Molla, Mohammad Habibur Rahman;
Abdulrahman, Abdulrasheed O.;
Rajia, Sultana;
Ahammad, Foysal;
Hasan, Md Nazmul;
Qadri, Ishtiaq;
Kim, Bonglee

Publication type:

Article

Investigation of the Anticancer Effect of α -Aminophosphonates and Arylidine Derivatives of 3-Acetyl-1-aminoquinolin-2(1H)-one on the DMBA Model of Breast Cancer in Albino Rats with In Silico Prediction of Their Thymidylate Synthase Inhibitory Effect

Published in:

Molecules, 2022, v. 27, n. 3, p. 756, doi. 10.3390/molecules27030756

By:

Nassan, Mohamed A.;
Aldhahrani, Adil;
Amer, Hamada H.;
Elhenawy, Ahmed;
Swelum, Ayman A.;
Ali, Omar M.;
Zaki, Yasser H.

Publication type:

Article

Coptidis Rhizoma Extract Reverses 5-Fluorouracil Resistance in HCT116 Human Colorectal Cancer Cells via Modulation of Thymidylate Synthase.

Published in:

Molecules, 2021, v. 26, n. 7, p. 1856, doi. 10.3390/molecules26071856

By:

Kang, Yong-Hwi;
Lee, Jin-Seok;
Lee, Nam-Hun;
Kim, Seung-Hyung;
Seo, Chang-Seob;
Son, Chang-Gue;
Yokosuka, Akihito

Publication type:

Article

Chemistry of Fluorinated Pyrimidines in the Era of Personalized Medicine.

Published in:

Molecules, 2020, v. 25, n. 15, p. 3438, doi. 10.3390/molecules25153438

By:

Gmeiner, William H.

Publication type:

Article

Alvaxanthone, a Thymidylate Synthase Inhibitor with Nematocidal and Tumoricidal Activities.

Published in:

Molecules, 2020, v. 25, n. 12, p. 2894, doi. 10.3390/molecules25122894

By:

Maj, Piotr;
Mori, Mattia;
Sobich, Justyna;
Markowicz, Joanna;
Uram, Łukasz;
Zieliński, Zbigniew;
Quaglio, Deborah;
Calcaterra, Andrea;
Cau, Ylenia;
Botta, Bruno;
Rode, Wojciech;
Geronikaki, Athina

Publication type:

Article

Cyclic Peptides Acting as Allosteric Inhibitors of Human Thymidylate Synthase and Cancer Cell Growth.

Published in:

Molecules, 2019, v. 24, n. 19, p. 3493, doi. 10.3390/molecules24193493

By:

Pacifico, Salvatore;
Santucci, Matteo;
Luciani, Rosaria;
Saxena, Puneet;
Linciano, Pasquale;
Ponterini, Glauco;
Lauriola, Angela;
D'Arca, Domenico;
Marverti, Gaetano;
Guerrini, Remo;
Costi, Maria Paola;
Cobb, Steven L.

Publication type:

Article

Targeting Methyltransferases in Human Pathogenic Bacteria: Insights into Thymidylate Synthase (TS) and Flavin-Dependent TS (FDTS).

Published in:

Molecules, 2019, v. 24, n. 8, p. 1638, doi. 10.3390/molecules24081638

By:

Pozzi, Cecilia;
Lopresti, Ludovica;
Tassone, Giusy;
Mangani, Stefano

Publication type:

Article

Structural and Functional Characterization of the Human Thymidylate Synthase (hTS) Interface Variant R175C, New Perspectives for the Development of hTS Inhibitors.

Published in:

Molecules, 2019, v. 24, n. 7, p. 1362, doi. 10.3390/molecules24071362

By:

Pozzi, Cecilia;
Ferrari, Stefania;
Luciani, Rosaria;
Costi, Maria Paola;
Mangani, Stefano

Publication type:

Article

Ultrasound Mediated One-Pot, Three Component Synthesis, Docking and ADME Prediction of Novel 5-Amino-2-(4-chlorophenyl)-7-Substituted Phenyl-8,8a-dihydro-7H-(1,3,4)thiadiazolo(3,2-α) pyrimidine-6-carbonitrile Derivatives as Anticancer Agents.

Published in:

Molecules, 2016, v. 21, n. 8, p. 894, doi. 10.3390/molecules21080894

By:

Tiwari, Shailee V.;
Seijas, Julio A.;
Vazquez-Tato, M. Pilar;
Sarkate, Aniket P.;
Lokwani, Deepak K.;
Nikalje, Anna Pratima G.

Publication type:

Article

Linking Protein Motion to Enzyme Catalysis.

Published in:

Molecules, 2015, v. 20, n. 1, p. 1192, doi. 10.3390/molecules20011192

By:

Singh, Priyanka;
Abeysinghe, Thelma;
Kohen, Amnon

Publication type:

Article

Isotope Effects as Probes for Enzyme Catalyzed Hydrogen-Transfer Reactions.

Published in:

Molecules, 2013, v. 18, n. 5, p. 5543, doi. 10.3390/molecules18055543

By:

Roston, Daniel;
Islam, Zahidul;
Kohen, Amnon

Publication type:

Article

Assessing immunogenicity of CRISPR-NCas9 engineered strain against porcine epidemic diarrhea virus.

Published in:

Applied Microbiology & Biotechnology, 2024, v. 108, n. 1, p. 1, doi. 10.1007/s00253-023-12989-0

By:

Li, Fengsai;
Zhao, Haiyuan;
Sui, Ling;
Yin, Fangjie;
Liu, Xinzi;
Guo, Guihai;
Li, Jiaxuan;
Jiang, Yanping;
Cui, Wen;
Shan, Zhifu;
Zhou, Han;
Wang, Li;
Qiao, Xinyuan;
Tang, Lijie;
Wang, Xiaona;
Li, Yijing

Publication type:

Article

Capecitabine-mediated heart failure in colorectal cancer: a case series.

Published in:

2021

By:

McAndrew, Erin N;
Jassal, Davinder S;
Goldenberg, Benjamin A;
Kim, Christina A

Publication type:

Case Study

Thymidylate Synthase Overexpression Drives the Invasive Phenotype in Colon Cancer Cells.

Published in:

Biomedicines, 2022, v. 10, n. 6, p. 1267, doi. 10.3390/biomedicines10061267

By:

Ciszewski, Wojciech M.;
Chmielewska-Kassassir, Małgorzata;
Wozniak, Lucyna A.;
Sobierajska, Katarzyna

Publication type:

Article