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Title: Autoimmune hemolytic anemia as a first manifestation of primary effusion lymphoma.
Authors: Chiba, H.; Matsunaga, T.; Kuribayashi, K.; Nikaido, T.; Shirao, S.; Murakami, K.; Hirayama, Y.; Sakamaki, S.; Ikeda, H.; Niitsu, Y.
Abstract: A 55-year-old man developing transfusion-dependant anemia was diagnosed with autoimmune hemolytic anemia (AIHA). Although he received prednisolone (PSL) (daily 60 mg), his hemoglobin level continued to decrease. After 3 weeks of treatment, he presented with a distension of the abdomen. Cytological examination of ascitic fluid revealed large, immunoblastic lymphocytes with plasmacytoid features and abundant IgM chains on the cellular surface; this was diagnosed as primary effusion lymphoma (PEL). Administration of CHOP (cyclophosphamide, Adriamycin, vincristine, and PSL) chemotherapy elicited regression of ascites as well as recovery of hemoglobin level. We hypothesize that PEL cells generated antibodies against red blood cells, resulting in AIHA resistance to PSL.
Subjects: HEMOLYTIC anemia; HEMOLYSIS & hemolysins; ERYTHROCYTES; BLOOD proteins
Publication: Annals of Hematology, 2003, Vol 82, Issue 12, p773
ISSN: 0939-5555
Publication type: Academic Journal
DOI: 10.1007/s00277-003-0734-x

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Autoimmune hemolytic anemia as a first manifestation of primary effusion lymphoma.