Thromboembolic Events Following Splenectomy: Risk Factors, Prevention, Management and Outcomes.

Rottenstreich, Amihai; Kleinstern, Geffen; Spectre, Galia; Da’as, Nael; Ziv, Esther; Kalish, Yosef

Background: Thromboembolic events following splenectomy are not uncommon. However, the role of thromboprophylaxis and risk factors for thrombosis, as well as the clinical course and outcomes, are not well characterized.Methods: A retrospective review of individuals who underwent splenectomy between January 2006 and December 2015 in two university hospitals.Results: Overall, 297 patients underwent splenectomy [open splenectomy (<italic>n</italic> = 199), laparoscopic splenectomy (<italic>n</italic> = 98)]. Mechanical (thigh-length pneumatic compression stockings) and pharmacologic thromboprophylaxis (40 mg enoxaparin daily, starting 12 h after surgery until discharge) was provided for all patients. One hundred and sixteen patients (39%) also received an extended thromboprophylaxis course of enoxaparin for 2–4 weeks after discharge. Twenty-three patients (7.7%) experienced thrombotic complications following splenectomy, including 16 cases (5.4%) of portal-splenic mesenteric venous thrombosis (PSMVT), 5 (1.7%) pulmonary embolism and 2 (0.7%) deep vein thrombosis. Longer operative time (mean operative time of 405 vs. 273 min, <italic>P</italic> = 0.03) was independently associated with PSMVT. Post-splenectomy thrombocytosis was not associated with thrombosis (<italic>P</italic> = 0.41). The overall thrombosis rate was significantly lower in patients who received an extended thromboprophylaxis course following splenectomy (3.4 vs. 10.5%, <italic>P</italic> = 0.02). Complete resolution of thrombosis was observed in most cases (<italic>n</italic> = 20, 87.0%), with no recurrent thrombosis during a mean follow-up of 38 ± 25 months.Conclusions: Thromboembolic complications, mainly PSMVT, are common following splenectomy. Longer operative time was associated with thrombosis. Significantly lower rates of thrombosis were found in patients who received an extended thromboprophylaxis course.

THROMBOEMBOLISM prevention; THROMBOSIS risk factors; SPLENECTOMY; ENOXAPARIN; THROMBOSIS; CARDIOVASCULAR disease treatment; THROMBOSIS complications; SURGICAL complications; THERAPEUTICS

World Journal of Surgery, 2018, Vol 42, Issue 3, p675

0364-2313

Academic Journal

10.1007/s00268-017-4185-2