Results
Title

Evaluation of P-glycoprotein function at the blood–brain barrier using [<sup>18</sup>F]MC225-PET.

Authors

Mossel, Pascalle; Garcia Varela, Lara; Arif, Wejdan M.; van der Weijden, Chris W. J.; Boersma, Hendrikus H.; Willemsen, Antoon T. M.; Boellaard, Ronald; Elsinga, Philip H.; Borra, Ronald J. H.; Colabufo, Nicola A.; Toyohara, Jun; de Deyn, Peter Paul; Dierckx, Rudi A. J. O.; Lammertsma, Adriaan A.; Bartels, Anna L.; Luurtsema, Gert

Abstract

[ SP 18 sp F]MC225 is a weaker P-gp substrate and has shown higher brain uptake than I (R)- i [ SP 11 sp C]verapamil at baseline in preclinical studies [[2]]. P-glycoprotein (P-gp) is an ATP-dependent efflux transporter located at the blood-brain barrier (BBB), involved in the transport of a variety of neurotoxic substances out of the brain. Evaluation of P-glycoprotein function at the blood-brain barrier using [18F]MC225-PET.

Subjects

BLOOD-brain barrier; POSITRON emission tomography

Publication

European Journal of Nuclear Medicine & Molecular Imaging, 2021, Vol 48, Issue 12, p4105

ISSN

1619-7070

Publication type

Academic Journal

DOI

10.1007/s00259-021-05419-8