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- Title
Multireflection propagation of conformational kinks in a two-component model of DNA as the transfer mode of the transcriptional replication fork.
- Authors
Shikhovtseva, E. S.; Nazarov, V. N.
- Abstract
The propagation, or movement, of a conformational kink along a linear structure can occur in capture, transfer, or multireflection modes. Here we use a model for two-component bistable polymer molecules with energetically non-equivalent stable states to model the propagation of the DNA transcription bubble via movement of a non-linear longitudinal stretching region along the DNA chain. We show that under certain conditions the longitudinal excitation can act as a reflector for a conformational kink and, furthermore, that conformational switching may propagate in a multireflection mode alongside conformational kink transition and conformational kink trapping.
- Subjects
DNA replication; GENETIC transcription; NUCLEIC acid isolation methods; CONFORMATIONAL analysis; DNA analysis
- Publication
European Biophysics Journal, 2018, Vol 47, Issue 1, p69
- ISSN
0175-7571
- Publication type
Academic Journal
- DOI
10.1007/s00249-017-1230-x