Title: Predictive Role of Serotonin Receptor (5HTR2A) and Dopamine Receptor (DRD2) gene polymorphisms in risperidone-induced weight gain and hyperprolactinemia in patients with schizophrenia.
Authors: Goud, Alladi Charanraj; Rajkumar, Ravi Philip; Shewade, Deepak Gopal; Goenka, Luxitaa; Srinivasamurthy, Suresh Kumar
Abstract: The article focuses on exploring the long-term adverse effects of risperidone, a second-generation antipsychotic used in schizophrenia (SCZ) management, and how genetic variations influence individual susceptibility to these side effects. Topics include the mechanisms of risperidone's action on dopamine and serotonin receptors, the impact of genetic polymorphisms on treatment-related adverse outcomes.
Subjects: INDIA; DRUG therapy for schizophrenia; BLOOD collection; LOGISTIC regression analysis; KRUSKAL-Wallis Test; RISPERIDONE; DESCRIPTIVE statistics; MANN Whitney U Test; GENETIC polymorphisms; PROLACTIN; PHARMACOGENOMICS; SEROTONIN receptors; DOPAMINE; DATA analysis software; WEIGHT gain; PITUITARY diseases
Publication: European Journal of Clinical Pharmacology, 2025, Vol 81, Issue 6, p899
ISSN: 0031-6970
Publication type: Academic Journal
DOI: 10.1007/s00228-025-03835-5

Predictive Role of Serotonin Receptor (5HTR2A) and Dopamine Receptor (DRD2) gene polymorphisms in risperidone-induced weight gain and hyperprolactinemia in patients with schizophrenia.

Goud, Alladi Charanraj; Rajkumar, Ravi Philip; Shewade, Deepak Gopal; Goenka, Luxitaa; Srinivasamurthy, Suresh Kumar