Works matching Pharmacodynamics

Results: 5000

中药配方颗粒药效学及与饮片药效比较研究进展.

Published in:

Journal of Shenyang Pharmaceutical University, 2024, v. 41, n. 8, p. 978, doi. 10.14066/j.cnki.cn21-1349/г.2023.0562

By:

田闵元;
陶晓倩;
韩子璇;
刘梦;
李佳;
杨立茹;
关雪峰;
张纯刚

Publication type:

Article

Pharmacodynamics of NOSO-502 studied in vitro and in vivo: determination of the dominant pharmacodynamic index driver.

Published in:

Journal of Antimicrobial Chemotherapy (JAC), 2025, v. 80, n. 3, p. 752, doi. 10.1093/jac/dkae469

By:

van den Berg, Sanne;
Attwood, Marie G L;
Griffin, Pippa;
Sassen, Sebastiaan D T;
Muller, Anouk E;
Raaphorst, Merel N;
Gualtieri, Maxime;
Racine, Emilie;
Das, Shampa;
Noel, Alan R;
Meletiadis, Joseph;
MacGowan, Alasdair P

Publication type:

Article

Role of mechanistically-based pharmacokinetic/pharmacodynamic models in drug development : a case study of a therapeutic protein.

Published in:

2006

By:

Marshall, Scott;
Macintyre, Fiona;
James, Ian;
Krams, Michael;
Jonsson, Niclas E.

Publication type:

journal article

Pharmacokinetic/pharmacodynamic modelling of antibacterials in vitro and in vivo using bacterial growth and kill kinetics: the minimum inhibitory concentration versus stationary concentration.

Published in:

2005

By:

Mouton, Johan W.;
Vinks, Alexander A.

Publication type:

journal article

Pharmacokinetics and pharmacodynamics of systemically administered glucocorticoids.

Published in:

2005

By:

Czock, David;
Keller, Frieder;
Franz Maximilian Rasche, Frieder;
Häussler, Ulla;
Rasche, Franz Maximilian;
Häussler, Ulla

Publication type:

journal article

Avoidance of bleeding during surgery in patients receiving anticoagulant and/or antiplatelet therapy: pharmacokinetic and pharmacodynamic considerations.

Published in:

2004

By:

Harder, Sebastian;
Klinkhardt, Ute;
Alvarez, John M.

Publication type:

journal article

Clinical use of ceftriaxone: a pharmacokinetic-pharmacodynamic perspective on the impact of minimum inhibitory concentration and serum protein binding.

Published in:

2001

By:

Perry, T.R.;
Schentag, J.J.

Publication type:

journal article

Comparative pharmacokinetics and pharmacodynamics of the newer fluoroquinolone antibacterials.

Published in:

2001

By:

Aminimanizani, A.;
Beringer, P.;
Jelliffe, R.

Publication type:

journal article

Pharmacokinetic-pharmacodynamic relationships of apomorphine in patients with Parkinson's disease.

Published in:

1999

By:

Neef, C.;
van Laar, T.

Publication type:

journal article

Achieving an optimal outcome in the treatment of infections. The role of clinical pharmacokinetics and pharmacodynamics of antimicrobials.

Published in:

1999

By:

Li, R.C.;
Zhu, M.;
Schentag, J.J.

Publication type:

journal article

Methodological issues in pharmacokinetic-pharmacodynamic modelling.

Published in:

1998

By:

Bellissant, E.;
Sébille, V.;
Paintaud, G.;
Sébille, V

Publication type:

journal article

Pharmacokinetic and pharmacodynamic changes in the elderly. Clinical implications.

Published in:

1998

By:

Hämmerlein, A.;
derendorf, H.;
Lowenthal, D.T.;
Hämmerlein, A

Publication type:

journal article

Key considerations based on pharmacokinetic/pharmacodynamic in the design of antibody-drug conjugates.

Published in:

Frontiers in Oncology, 2025, p. 1, doi. 10.3389/fonc.2024.1459368

By:

Gao, Yangyang;
Xia, Yuwei;
Chen, Yixin;
Zhou, Shiqi;
Fang, Yingying;
Yu, Jieru;
Zhang, Leyin;
Sun, Leitao

Publication type:

Article

Pharmacodynamic model of slow reversible binding and its applications in pharmacokinetic/pharmacodynamic modeling: review and tutorial.

Published in:

Journal of Pharmacokinetics & Pharmacodynamics, 2022, v. 49, n. 5, p. 493, doi. 10.1007/s10928-022-09822-y

By:

Ren, Tianjing;
Zhu, Xu;
Jusko, Natalie M.;
Krzyzanski, Wojciech;
Jusko, William J.

Publication type:

Article

Pharmacodynamics of Intravenous and Oral Midazolam in Preterm Infants.

Published in:

Clinical Drug Investigation, 2003, v. 23, n. 1, p. 27, doi. 10.2165/00044011-200323010-00004

By:

de Wildt, S.N.;
Kearns, G.L.;
Sie, S.D.;
Hop, W.C.J.;
van den Anker, J.N.

Publication type:

Article

Pharmacokinetics and Pharmacodynamics of Continuous and Intermittent Ceftazidime during the Treatment of Nosocomial Pneumonia.

Published in:

Clinical Drug Investigation, 1999, v. 18, n. 2, p. 133, doi. 10.2165/00044011-199918020-00006

By:

Nicolau, D.P.;
McNabb, J.;
Lacy, M.K.;
Li, J.;
Quintiliani, R.;
Nightingale, C.H.

Publication type:

Article

Recombinant Human Interferon-β-1a (Rebif) vs Recombinant Interferon-β-1b (Betaseron) in Healthy Volunteers: A Pharmacodynamic and Tolerability Study.

Published in:

Clinical Drug Investigation, 1999, v. 18, n. 1, p. 27, doi. 10.2165/00044011-199918010-00004

By:

Buraglio, M.;
Trinchard-Lugan, I.;
Munafo, A.;
Macnamee, M.

Publication type:

Article

Pharmacokinetics and Pharmacodynamics of Newer Oral Cephalosporins: Implications for Treatment of Community-Acquired Lower Respiratory Tract Infections.

Published in:

Clinical Drug Investigation, 1998, v. 16, n. 4, p. 335, doi. 10.2165/00044011-199816040-00008

By:

Cazzola, M.;
Matera, M.G.;
Donner, C.F.

Publication type:

Article

Characterization of Neutropenia in Advanced Cancer Patients Following Palbociclib Treatment Using a Population Pharmacokinetic-Pharmacodynamic Modeling and Simulation Approach.

Published in:

Journal of Clinical Pharmacology, 2017, v. 57, n. 9, p. 1159, doi. 10.1002/jcph.902

By:

Sun, Wan;
O'Dwyer, Peter J.;
Finn, Richard S.;
Ruiz‐Garcia, Ana;
Shapiro, Geoffrey I.;
Schwartz, Gary K.;
DeMichele, Angela;
Wang, Diane

Publication type:

Article

Plasma and cerebrospinal fluid concentrations of ibuprofen in pediatric patients and antipyretic effect: Pharmacokinetic-pharmacodynamic modeling analysis.

Published in:

Journal of Clinical Pharmacology, 2014, v. 54, n. 9, p. 1023, doi. 10.1002/jcph.307

By:

Har‐Even, Ronly;
Stepensky, David;
Britzi, Malka;
Soback, Stefan;
Chaim, Adina Bar;
Brandriss, Norit;
Goldman, Michael;
Berkovitch, Matitiahu;
Kozer, Eran

Publication type:

Article

Population pharmacokinetic and pharmacodynamic modeling of different formulations of ONO-5334, cathepsin K inhibitor, in Caucasian and Japanese postmenopausal females.

Published in:

Journal of Clinical Pharmacology, 2014, v. 54, n. 1, p. 23, doi. 10.1002/jcph.186

By:

Hasegawa, Chihiro;
Ohno, Tomoya;
Umemura, Takeo;
Honda, Naoki;
Ohyama, Michiyo;
Nagase, Shinichi;
Small, Maria;
Deacon, Steve;
Ogawa, Mikio;
Ieiri, Ichiro

Publication type:

Article

Population Pharmacokinetic and Pharmacodynamic Model-Based Comparability Assessment of a Recombinant Human Epoetin Alfa and the Biosimilar HX575.

Published in:

Journal of Clinical Pharmacology, 2012, v. 52, n. 11, p. 1624, doi. 10.1177/0091270011421911

By:

Yan, Xiaoyu;
Lowe, Philip J.;
Fink, Martin;
Berghout, Alexander;
Balser, Sigrid;
Krzyzanski, Wojciech

Publication type:

Article

Population pharmacokinetic-pharmacodynamic modelling to describe the effects of paracetamol and N-acetylcysteine on the international normalized ratio.

Published in:

Clinical & Experimental Pharmacology & Physiology, 2015, v. 42, n. 1, p. 102, doi. 10.1111/1440-1681.12327

By:

Owens, Katie H;
Medlicott, Natalie J;
Zacharias, Mathew;
Whyte, Ian M;
Buckley, Nicholas A;
Reith, David M

Publication type:

Article

Rocuronium pharmacodynamic models for published five pharmacokinetic models: age and sex are covariates in pharmacodynamic models.

Published in:

Journal of Anesthesia, 2018, v. 32, n. 5, p. 709, doi. 10.1007/s00540-018-2543-3

By:

Masui, Kenichi;
Ishigaki, Sayaka;
Tomita, Atsuko;
Otake, Hiroshi

Publication type:

Article

A strategy for designing voriconazole dosage regimens to prevent invasive pulmonary aspergillosis based on a cellular pharmacokinetics/pharmacodynamics model.

Published in:

2018

By:

Wang, Taotao;
Zhang, Tao;
Meng, Ti;
Li, Ying;
Chen, Lu;
Yang, Qianting;
Dong, Haiyan;
Lei, Jin'e;
Chen, Limei;
Dong, Yalin

Publication type:

journal article

构建 LPS 诱导的急性炎症小鼠模型用于 IDO1 抑制剂药效动力学评价.

Published in:

Fudan University Journal of Medical Sciences, 2022, v. 49, n. 2, p. 257, doi. 10.3969/j.issn.1672-8467.2022.02.014

By:

施磊;
郭磊磊;
杨丹;
杨青

Publication type:

Article

The pharmacokinetic-pharmacodynamic model of telmisartan and hydrochlorothiazide on blood pressure and plasma potassium after long-term administration in spontaneously hypertensive rats.

Published in:

Fundamental & Clinical Pharmacology, 2015, v. 29, n. 6, p. 543, doi. 10.1111/fcp.12152

By:

Yu, Dan;
Chen, Yuancheng;
Hao, Kun

Publication type:

Article

Lamotrigine pharmacokinetic/pharmacodynamic modelling in rats.

Published in:

Fundamental & Clinical Pharmacology, 2005, v. 19, n. 6, p. 669, doi. 10.1111/j.1472-8206.2005.00380.x

By:

Castel-Branco, M. M.;
Falcão, A. C.;
Figueiredo, I. V.;
Caramona, M. M.

Publication type:

Article

Once versus Thrice Daily Tobramycin Alone and in Combination with Ceftazidime, Ciprofloxacin and Imipenem in an in vitro Pharmacodynamic Model.

Published in:

Chemotherapy (0009-3157), 1998, v. 44, n. 1, p. 1, doi. 10.1159/000007083

By:

Zelenitsky, Sheryl A.;
Karlowsky, James A.;
Hoban, Daryl J.;
Kabani, Amin;
Zhanel, George G.

Publication type:

Article

Shedding a Light on Acyclovir Pharmacodynamics: A Retrospective Analysis on Pharmacokinetic/Pharmacodynamic Modelling of Acyclovir for the Treatment of Varicella Zoster Virus Infection in Immunocompromised Patients: A Pilot Study.

Published in:

Pharmaceutics, 2022, v. 14, n. 11, p. 2311, doi. 10.3390/pharmaceutics14112311

By:

Grit, Geeske F.;
Märtson, Anne-Grete;
Knoester, Marjolein;
Toren-Wielema, Marlous L.;
Touw, Daan J.

Publication type:

Article

Physiologically Based Pharmacokinetic/Pharmacodynamic Modeling to Predict the Impact of CYP2C9 Genetic Polymorphisms, Co-Medication and Formulation on the Pharmacokinetics and Pharmacodynamics of Flurbiprofen.

Published in:

Pharmaceutics, 2020, v. 12, n. 11, p. 1049, doi. 10.3390/pharmaceutics12111049

By:

Loisios-Konstantinidis, Ioannis;
Cristofoletti, Rodrigo;
Jamei, Masoud;
Turner, David;
Dressman, Jennifer

Publication type:

Article

苍术野生品与栽培品的药效学比较.

Published in:

Traditional Chinese Drug Research & Clinical Pharmacology, 2025, v. 36, n. 2, p. 214, doi. 10.19378/j.issn.1003-9783.2025.02.007

By:

林智;
王心荷;
张文静;
王雨辰;
律广富;
孙铭阳;
林贺;
林喆

Publication type:

Article

基于病症模型的经方四妙丸防治高尿酸血症痛风的药效物质探讨.

Published in:

Traditional Chinese Drug Research & Clinical Pharmacology, 2024, v. 35, n. 8, p. 1152, doi. 10.19378/j.issn.1003-9783.2024.08.006

By:

曾永长;
梁少瑜;
吴俊洪;
徐丹丹;
刘常青;
何康;
金宇;
吴正治

Publication type:

Article

姜黄素纳米乳的制备和药动学及药效学研究.

Published in:

Journal of Pharmaceutical Practice & Service, 2023, v. 41, n. 7, p. 416, doi. 10.12206/j.issn.2097-2024.202209084

By:

骆锦前;
王婷;
尤本明;
陈方剑

Publication type:

Article

Pharmacodynamic model of dopamine D1 receptor agonists in the treatment of breast cancer lung metastasis.

Published in:

Journal of Chinese Pharmaceutical Sciences, 2020, v. 29, n. 1, p. 45, doi. 10.5246/jcps.2020.01.004

By:

Liang Yang;
Ye Yao;
Yaoyao Feng;
Wei Lu;
Tianyan Zhou

Publication type:

Article

Mechanism-based pharmacokinetic/pharmacodynamic modeling of the effects of sitagliptin on DPP-4 activity, insulin and glucose in diabetic rats.

Published in:

Journal of Chinese Pharmaceutical Sciences, 2018, v. 27, n. 6, p. 371, doi. 10.5246/jcps.2018.06.038

By:

Ye Yao;
Xiangfei Jiu;
Siyuan Wang;
Wei Lu;
Tianyan Zhou

Publication type:

Article

Population pharmacokinetics and pharmacodynamics of meropenem in Japanese pediatric patients.

Published in:

Journal of Infection & Chemotherapy (Springer Science & Business Media B.V.), 2010, v. 16, n. 2, p. 139, doi. 10.1007/s10156-009-0025-0

By:

Ikawa, Kazuro;
Morikawa, Norifumi;
Ikeda, Kayo;
Miki, Mizuka;
Kobayashi, Masao

Publication type:

Article

Multiplex Quantitative Analysis of 9 Compounds of Scutellaria baicalensis Georgi in the Plasma of Respiratory Syncytial Virus-Infected Mice Based on HPLC-MS/MS and Pharmacodynamic Effect Correlation Analysis.

Published in:

Molecules, 2023, v. 28, n. 16, p. 6001, doi. 10.3390/molecules28166001

By:

Wang, Yanghai;
Jia, Mingqian;
Gao, Yan;
Zhao, Bonian

Publication type:

Article

A direct comparison of the pharmacodynamic properties of insulin detemir and neutral protamine lispro insulin in patients with type 1 diabetes A direct comparison of the pharmacodynamic properties of insulin detemir and neutral protamine lispro insulin in patients with type 1 diabetes

Published in:

Diabetes, Obesity & Metabolism, 2013, v. 15, n. 3, p. 241, doi. 10.1111/dom.12016

By:

Korsatko, S.;
Glettler, K.;
Olsen, K. J.;
Wutte, A.;
Bock, G.;
Koehler, G.;
Mader, J. K.;
Semlitsch, B.;
Pieber, T. R.

Publication type:

Article

Ocrelizumab in relapsing and primary progressive multiple sclerosis: Pharmacokinetic and pharmacodynamic analyses of OPERA I, OPERA II and ORATORIO.

Published in:

British Journal of Clinical Pharmacology, 2021, v. 87, n. 6, p. 2511, doi. 10.1111/bcp.14658

By:

Gibiansky, Ekaterina;
Petry, Claire;
Mercier, Francois;
Günther, Andreas;
Herman, Ann;
Kappos, Ludwig;
Hauser, Stephen;
Yamamoto, Yumi;
Wang, Qing;
Model, Fabian;
Kletzl, Heidemarie

Publication type:

Article

Metformin and daclatasvir: absence of a pharmacokinetic-pharmacodynamic drug interaction in healthy volunteers.

Published in:

British Journal of Clinical Pharmacology, 2017, v. 83, n. 10, p. 2225, doi. 10.1111/bcp.13323

By:

Smolders, Elise J.;
Colbers, Angela;
Kanter, Clara T. M. M.;
Velthoven‐Graafland, Kirsten;
Wolberink, Leonie T.;
Ewijk‐Beneken Kolmer, Noor;
Drenth, Joost P. H.;
Aarnoutse, Rob E.;
Tack, Cees J.;
Burger, David M.

Publication type:

Article

Pharmacokinetic and pharmacodynamic profiling of a P2X7 receptor allosteric modulator GSK1482160 in healthy human subjects.

Published in:

British Journal of Clinical Pharmacology, 2013, v. 75, n. 1, p. 197, doi. 10.1111/j.1365-2125.2012.04320.x

By:

Ali, Zahid;
Laurijssens, Bart;
Ostenfeld, Thor;
McHugh, Simon;
Stylianou, Anastasia;
Scott‐Stevens, Paul;
Hosking, Louise;
Dewit, Odile;
Richardson, Jill C.;
Chen, Chao

Publication type:

Article

Pharmacokinetics and Pharmacodynamics of Curcumin-Loaded Solid Lipid Nanoparticles in the Management of Streptozotocin-Induced Diabetes Mellitus: Application of Central Composite Design.

Published in:

Assay & Drug Development Technologies, 2021, v. 19, n. 4, p. 262, doi. 10.1089/adt.2021.017

By:

Sharma, Jai Bharti;
Bhatt, Shailendra;
Saini, Vipin;
Kumar, Manish

Publication type:

Article

Optimal starting dosing regimen of intravenous oxytocin for labor induction based on the population kinetic‐pharmacodynamic model of uterine contraction frequency.

Published in:

Pharmacotherapy, 2024, v. 44, n. 4, p. 319, doi. 10.1002/phar.2911

By:

Yu, Zhiheng;
Chen, Rong;
Zhao, Cheng;
Zhang, Renwei;
Zhou, Tianyan;
Zhao, Yangyu

Publication type:

Article

Dosage exploration of meloxicam according to CYP2C9 genetic polymorphisms based on a population pharmacokinetic‐pharmacodynamic model.

Published in:

Pharmacotherapy, 2023, v. 43, n. 2, p. 145, doi. 10.1002/phar.2762

By:

Jang, Ji‐Hun;
Jeong, Seung‐Hyun;
Lee, Yong‐Bok

Publication type:

Article

Molecular Adsorbent Recirculating System Therapy with Continuous Renal Replacement Therapy Enhanced Clearance of Piperacillin in a Pediatric Patient and Led to Failure to Attain Pharmacodynamic Targets.

Published in:

Pharmacotherapy, 2020, v. 40, n. 10, p. 1061, doi. 10.1002/phar.2462

By:

Tang Girdwood, Sonya;
Arbough, Trent;
Dong, Min;
Mizuno, Tomoyuki;
Tang, Peter;
Vinks, Alexander A.;
Kaplan, Jennifer

Publication type:

Article

Population Pharmacokinetics and Pharmacodynamic Target Attainment of Ampicillin in Neonates with Hypoxemic-Ischemic Encephalopathy in the Setting of Controlled Hypothermia.

Published in:

Pharmacotherapy, 2017, v. 37, n. 4, p. 456, doi. 10.1002/phar.1916

By:

Cies, Jeffrey J.;
Fugarolas, Keri N.;
Moore, Wayne S.;
Mason, Robert W.;
Menkiti, Ogechukwu R.

Publication type:

Article

Pharmacokinetic and Pharmacodynamic Analyses of Ceftaroline in Adults with Cystic Fibrosis.

Published in:

Pharmacotherapy, 2016, v. 36, n. 1, p. 13, doi. 10.1002/phar.1681

By:

Autry, Elizabeth B.;
Rybak, Jeffrey M.;
Leung, Noelle R.;
Gardner, Brian M.;
Burgess, Donna R.;
Anstead, Michael I.;
Kuhn, Robert J.

Publication type:

Article

Pharmacodynamics and Pharmacokinetics of Fluticasone Furoate/Vilanterol in Healthy Chinese Subjects.

Published in:

Pharmacotherapy, 2015, v. 35, n. 6, p. 586, doi. 10.1002/phar.1598

By:

Chen, Xia;
Zheng, Xin;
Jiang, Ji;
Hu, Pei;
Wu, Kai;
Zhuang, Lihong;
Liu, Lian;
Du, Xin;
Kempsford, Rodger;
Allen, Ann

Publication type:

Article

Comparison of the pharmacokinetics and pharmacodynamics of biphasic insulin aspart and insulin glargine in people with type 2 diabetes.

Published in:

Diabetologia, 2006, v. 49, n. 6, p. 1163, doi. 10.1007/s00125-006-0243-2

By:

Luzio, S.;
Dunseath, G.;
Peter, R.;
Pauvaday, V.;
Owens, D. R.

Publication type:

Article