Title: Pathophysiology of Bone Fragility in Patients with Diabetes.
Authors: Palermo, Andrea; D'Onofrio, Luca; Buzzetti, Raffaella; Manfrini, Silvia; Napoli, Nicola
Abstract: It has been well established that bone fragility is one of the chronic complications of diabetes mellitus, and both type 1 and type 2 diabetes are risk factors for fragility fractures. Diabetes may negatively affect bone health by unbalancing several pathways: bone formation, bone resorption, collagen formation, inflammatory cytokine, muscular and incretin system, bone marrow adiposity and calcium metabolism. The purpose of this narrative review is to explore the current understanding of pathophysiological pathways underlying bone fragility in diabetics. In particular, the review will focus on the peculiar cellular and molecular system impairment that may lead to increased risk of fracture in type 1 and type 2 diabetes.
Subjects: PEOPLE with diabetes; BONE fractures; PATHOLOGICAL physiology; CALCIUM metabolism; FRAGILITY (Psychology); DISEASE risk factors; TYPE 2 diabetes complications; BONES; TYPE 1 diabetes; SYSTEMATIC reviews; DISEASE complications
Publication: Calcified Tissue International, 2017, Vol 100, Issue 2, p122
ISSN: 0171-967X
Publication type: Academic Journal
DOI: 10.1007/s00223-016-0226-3

Pathophysiology of Bone Fragility in Patients with Diabetes.

Palermo, Andrea; D'Onofrio, Luca; Buzzetti, Raffaella; Manfrini, Silvia; Napoli, Nicola