Results
Title

Advanced LC-MS-based methods to study the co-occurrence and metabolization of multiple mycotoxins in cereals and cereal-based food.

Authors

Malachová, Alexandra; Stránská, Milena; Václavíková, Marta; Elliott, Christopher T.; Black, Connor; Meneely, Julie; Hajšlová, Jana; Ezekiel, Chibundu N.; Schuhmacher, Rainer; Krska, Rudolf

Abstract

Liquid chromatography (LC) coupled with mass spectrometry (MS) is widely used for the determination of mycotoxins in cereals and cereal-based products. In addition to the regulated mycotoxins, for which official control is required, LC-MS is often used for the screening of a large range of mycotoxins and/or for the identification and characterization of novel metabolites. This review provides insight into the LC-MS methods used for the determination of co-occurring mycotoxins with special emphasis on multiple-analyte applications. The first part of the review is focused on targeted LC-MS approaches using cleanup methods such as solid-phase extraction and immunoaffinity chromatography, as well as on methods based on minimum cleanup (quick, easy, cheap, effective, rugged, and safe; QuEChERS) and dilute and shoot. The second part of the review deals with the untargeted determination of mycotoxins by LC coupled with high-resolution MS, which includes also metabolomics techniques to study the fate of mycotoxins in plants.

Subjects

CEREALS as food; MYCOTOXINS; LIQUID chromatography-mass spectrometry; NUTRITION; FUSARIUM

Publication

Analytical & Bioanalytical Chemistry, 2018, Vol 410, Issue 3, p801

ISSN

1618-2642

Publication type

Academic Journal

DOI

10.1007/s00216-017-0750-7