Preparation of monodisperse curcumin-imprinted polymer by precipitation polymerization and its application for the extraction of curcuminoids from Curcuma longa L.

Kitabatake, Tomoko; Tabo, Hiromi; Matsunaga, Hisami; Haginaka, Jun

A monodisperse molecularly imprinted polymer (MIP) for curcumin was first prepared by precipitation polymerization using methacrylamide (MAM) and 4-vinylpyridine as functional co-monomers, divinylbenzene as a crosslinker, and a mixture of acetonitrile and toluene as a porogen. The use of MAM as the co-monomer resulted in the formation of a monodisperse MIP and non-imprinted polymer (NIP). MIP and NIP, respectively, were monodispersed with a narrow particle size distribution (3.3 ± 0.09 and 3.5 ± 0.10 μm). In addition to shape recognition, hydrophobic and hydrogen-bonding interactions affected the retention and molecular-recognition of curcumin on the MIP. The MIP for curcumin could extract curcuminoids (curcumin, demethoxycurcumin, and bisdemethoxycurcumin) in Curcuma longa L. [Figure not available: see fulltext.]

IMPRINTED polymers; TURMERIC; CURCUMIN; CURCUMINOIDS; POLYMERIZATION; PRECIPITATION (Chemistry); VINYLPYRIDINE

Analytical & Bioanalytical Chemistry, 2013, Vol 405, Issue 20, p6555

1618-2642

Academic Journal

10.1007/s00216-013-7088-6