Untitled.

Niu, Cheng-Gang; Li, Zhi-Zhang; Zhang, Xiao-Bing; Lin, Wei-Qi; Shen, Guo-Li; Yu, Ru-Qin

By replacing the hydrogen of the 4-amino group of a 4-amino-1,8-naphthalimide derivative with an N-acryloxyethyl group, the fluorophore has been covalently immobilized on an optical sensor surface by UV photopolymerization. The optical sensor obtained can be used for the determination of picric acid. The linear range and detection limit of the sensor are 9.80×10–7–1.96×10–4 mol L–1 and 7.1×10–7 mol L–1, respectively. Leaching of the fluorophore from the membrane is effectively prevented by covalent immobilization, resulting in a sensor with a relatively long lifetime. The response time of the sensor is short, and the reproducibility and reversibility are good. The sensor has been used for the indirect determination of the chloroquine content of pharmaceutical tablets.

Analytical & Bioanalytical Chemistry, 2002, Vol 372, Issue 4, p519

1618-2642

Academic Journal

10.1007/s00216-001-1141-6