Title: Welche Faktoren beeinflussen die Serumkonzentration von Levetiracetam?
Authors: Bauer, J.; Pfeiffer, C.; Burr, W.
Abstract: We evaluated factors possibly influencing serum concentrations of levetiracetam (LEV-SC). The study included 163 patients with epilepsy (91 men, 72 women; mean age 39.6 years). The duration of treatment on first analysis was 226 days; the mean daily dose amounted to 2,434 mg. In each patient between one and seven measurements were carried out (mean 2.2). LEV-SC significantly depended on daily dosage and the interval between the time the medication was taken and the time of blood extraction. A marked drop in LEV-SC was observed 4-5 h following ingestion. Carbamazepine, oxcarbazepine and clobazam reduced LEV-SC, whereas valproate elevated LEV-SC significantly. When assessing evaluation of compliance these factors have to be taken into consideration when comparing intraindividual LEV-SC.
Subjects: EPILEPSY; DRUGS; SERUM; CARBAMAZEPINE; VALPROIC acid
Publication: Der Nervenarzt, 2010, Vol 81, Issue 4, p391
ISSN: 0028-2804
Publication type: Academic Journal
DOI: 10.1007/s00115-009-2906-y

Welche Faktoren beeinflussen die Serumkonzentration von Levetiracetam?

Bauer, J.; Pfeiffer, C.; Burr, W.