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Title

Welche Faktoren beeinflussen die Serumkonzentration von Levetiracetam?

Authors

Bauer, J.; Pfeiffer, C.; Burr, W.

Abstract

We evaluated factors possibly influencing serum concentrations of levetiracetam (LEV-SC). The study included 163 patients with epilepsy (91 men, 72 women; mean age 39.6 years). The duration of treatment on first analysis was 226 days; the mean daily dose amounted to 2,434 mg. In each patient between one and seven measurements were carried out (mean 2.2). LEV-SC significantly depended on daily dosage and the interval between the time the medication was taken and the time of blood extraction. A marked drop in LEV-SC was observed 4-5 h following ingestion. Carbamazepine, oxcarbazepine and clobazam reduced LEV-SC, whereas valproate elevated LEV-SC significantly. When assessing evaluation of compliance these factors have to be taken into consideration when comparing intraindividual LEV-SC.

Subjects

EPILEPSY; DRUGS; SERUM; CARBAMAZEPINE; VALPROIC acid

Publication

Der Nervenarzt, 2010, Vol 81, Issue 4, p391

ISSN

0028-2804

Publication type

Academic Journal

DOI

10.1007/s00115-009-2906-y

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