We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Allgemeiner Gesundheitsstatus Langzeitüberlebender von Gebärmutterhalskrebs nach Strahlentherapie.
- Authors
Sung Uk, Lee; Young Ae, Kim; Young-Ho, Yoon; Yeon-Joo, Kim; Myong Cheol, Lim; Sang-Yoon, Park; Sang-Soo, Seo; Ji Eun, Park; Joo-Young, Kim
- Abstract
<bold>Purpose: </bold>To evaluate the global health status of long-term cervical cancer survivors (LCCS) who survived for more than 4 years after curative radiation treatment (RT).<bold>Patients and Methods: </bold>Medical records of 562 women treated with RT in our institution between 2003 and 2010 were reviewed. Excluding 259 women who died of disease or were lost to follow-up, disease status and late morbidities were evaluated in 303 LCCS. Quality of life (QoL) was analyzed in 168 LCCS using a questionnaire from the European Organization for the Research and Treatment of Cancer, and the results were compared with an age-matched healthy Korean female population.<bold>Results: </bold>Median follow-up was 6.8 years (range 4.1-12.5 years). There were 14 deaths (7 cancer specific) and 14 recurrences (5 local recurrences and 9 distant metastases). The median time to recurrence was 6.0 years (range 4.1-8.2 years). Grade ≥2 late toxicities were frequently observed in the bladder (19%) and small/large intestine (15%). Multivariate analysis revealed a higher rate of late toxicity in patients aged ≥51 years at diagnosis (small/large intestine: hazard ratio, HR, 2.5 [1.2-5.5]; bladder: HR 2.4 [1.3-4.5]; and bone: HR 4.3 [1.2-15.8]) than patients aged <51 years. Compared to the general population, LCCS exhibited a significantly higher rate of body image concerns, sexual dysfunction, lymphedema, and peripheral neuropathy.<bold>Conclusion: </bold>New recurrences occurred in 5% of LCCS and grade ≥2 treatment-related morbidities were present in 33%. A significant proportion of LCCS also showed decreased cervical-cancer-specific QoL. These results suggest the need for long-term surveillance and follow-up care for LCCS.
- Subjects
QUALITY of life; MENTAL health; AGE distribution; BLADDER; HEALTH status indicators; HYSTERECTOMY; INTESTINES; LONGITUDINAL method; RADIATION doses; RADIATION injuries; SURVIVAL analysis (Biometry); TUMOR classification; PSYCHOLOGY; CERVIX uteri tumors; TUMOR treatment
- Publication
Strahlentherapie und Onkologie, 2017, Vol 193, Issue 7, p543
- ISSN
0179-7158
- Publication type
Academic Journal
- DOI
10.1007/s00066-017-1143-8