Works matching DE "DNA repair"

Results: 5000

PARP Inhibitors in Ovarian Cancer: Resistance Mechanisms, Clinical Evidence, and Evolving Strategies.

Published in:

Biomedicines, 2025, v. 13, n. 5, p. 1126, doi. 10.3390/biomedicines13051126

By:

Apelian, Shant;
Martincuks, Antons;
Whittum, Michelle;
Yasukawa, Maya;
Nguy, Lindsey;
Mathyk, Begum;
Andikyan, Vaagn;
Anderson, Matthew L.;
Rutherford, Thomas;
Cristea, Mihaela;
Stewart, Daphne;
Kohut, Adrian

Publication type:

Article

The Interplay Between DNA Repair and the Immune Microenvironment in Pancreatic Cancer.

Published in:

Biomedicines, 2025, v. 13, n. 5, p. 1031, doi. 10.3390/biomedicines13051031

By:

Ciner, Aaron;
Hosein, Peter J.;
Jiang, Yixing;
Rassool, Feyruz

Publication type:

Article

Biological Models of Oxidative Purine DNA Damage in Neurodegenerative Disorders.

Published in:

Antioxidants, 2025, v. 14, n. 5, p. 578, doi. 10.3390/antiox14050578

By:

Chatgilialoglu, Chryssostomos

Publication type:

Article

Effects of Cisplatin on the Radiation Response and DNA Damage Markers in Peripheral Blood Lymphocytes Ex Vivo.

Published in:

Cells (2073-4409), 2025, v. 14, n. 10, p. 682, doi. 10.3390/cells14100682

By:

Zahnreich, Sebastian;
Bhatti, Aisha;
Ahmad, Barea;
Drabke, Sophia;
Kaufmann, Justus;
Schmidberger, Heinz

Publication type:

Article

Mechanisms of DNA Damage Recognition by UDG and PARP1 in the Nucleosome.

Published in:

Biomolecules (2218-273X), 2025, v. 15, n. 5, p. 649, doi. 10.3390/biom15050649

By:

Ghediri, Safwen;
Sarma, Parvathy A. P.;
Saravanan, Vinnarasi;
Abbadie, Corinne;
Blossey, Ralf;
Cleri, Fabrizio

Publication type:

Article

Current Challenges With Highly Active Antiretroviral Therapy and New Hope and Horizon With CRISPR‐CAS9 Technology for HIV Treatment.

Published in:

Chemical Biology & Drug Design, 2025, v. 105, n. 5, p. 1, doi. 10.1111/cbdd.70121

By:

Zubair, Akmal;
Sujan, Arooba;
Ali, Muhammad;
Hussain, Syeda Maryam

Publication type:

Article

Elevated nonhomologous end-joining by AATF enables efficient DNA damage repair and therapeutic resistance in glioblastoma.

Published in:

Nature Communications, 2025, v. 16, n. 1, p. 1, doi. 10.1038/s41467-025-60228-z

By:

Mi, Lanjuan;
Cai, Yan;
Qi, Ji;
Chen, Lishu;
Li, Yuanyuan;
Zhang, Songyang;
Ran, Haowen;
Qi, Qinghui;
Zhang, Cheng;
Wu, Huiran;
Cao, Shuailiang;
Huang, Haohao;
Xiao, Dake;
Wang, Xinzheng;
Li, Bohan;
Xie, Jiong;
Li, Fangye;
Han, Qiuying;
Wu, Qiulian;
Li, Tao

Publication type:

Article

In-Silico Analysis of FANCD2 mutations presents in the FANCD2 protein MLS and their subsequent impacts.

Published in:

Bulletin of Pure & Applied Sciences-Zoology, 2024, v. 43A, n. 2, p. 242

By:

Mahto, Ram Balak

Publication type:

Article

Novel CRISPR/Cas9-Based Approaches for Quantitative Study of DSB Repair Mechanics.

Published in:

Biochemistry (00062979), 2025, v. 90, n. 4, p. 437, doi. 10.1134/S0006297924601813

By:

Smirnov, Alexander V.;
Yunusova, Anastasia M.

Publication type:

Article

Constitutional Mismatch Repair Deficiency: Scoping Review of a Cancer‐Predisposition Syndrome With Distinctive Cutaneous Findings.

Published in:

Pediatric Dermatology, 2025, v. 42, n. 3, p. 437, doi. 10.1111/pde.15878

By:

Mar, Kristie;
Ameri, Kimia;
Lam, Joseph M.

Publication type:

Article

PARP1-targeted alpha therapy enhances target expression.

Published in:

EJNMMI Research, 2025, v. 15, n. 1, p. 1, doi. 10.1186/s13550-025-01256-0

By:

Babazada, Hasan;
Martorano, Paul;
Lee, Hsiaoju;
Geng, Shuyao;
Batra, Vandana;
Maris, John M.;
Pryma, Daniel A.;
Gitto, Sarah B.;
Farwell, Michael D.

Publication type:

Article

Short Tandem Repeat (STR) Somatic Mutation in Non-Melanoma Skin Cancer (NMSC): Association with Transcriptomic Profile and Potential Implications for Therapy.

Published in:

Cancers, 2025, v. 17, n. 10, p. 1669, doi. 10.3390/cancers17101669

By:

Kibriya, Muhammad G.;
Almazan, Armando;
Argos, Maria;
Islam, Tariqul;
Shea, Christopher R.;
Ahsan, Habibul;
Jasmine, Farzana

Publication type:

Article

Clinical Characteristics and Survival of Ovarian Cancer Patients According to Homologous Recombination Deficiency Status.

Published in:

Cancers, 2025, v. 17, n. 10, p. 1628, doi. 10.3390/cancers17101628

By:

Sisman, Yagmur;
Schejbel, Lone;
Schnack, Tine Henrichsen;
Høgdall, Claus;
Høgdall, Estrid

Publication type:

Article

The Use of Mutational Signatures to Decipher the Inter-Relationship of Reactive Oxygen Species with Homologous Recombination and Non-Homologous End-Joining Deficiencies as Well as Their Effects on APOBEC Mutagenesis in Breast Cancer.

Published in:

Cancers, 2025, v. 17, n. 10, p. 1627, doi. 10.3390/cancers17101627

By:

Farmanbar, Amir;
Kneller, Robert;
Firouzi, Sanaz

Publication type:

Article

Tumor-associated macrophages contribute to cisplatin resistance via regulating Pol η-mediated translesion DNA synthesis in ovarian cancer.

Published in:

Cellular & Molecular Life Sciences, 2025, v. 82, n. 1, p. 1, doi. 10.1007/s00018-025-05731-8

By:

Chatterjee, Bilash;
Sarkar, Mrinmoy;
Ghosh, Debanjana;
Mishra, Sangita;
Bose, Subhankar;
Khan, Md. Maqsood Ahamad;
Ganesan, Senthil Kumar;
Chatterjee, Nabanita;
Srivastava, Amit Kumar

Publication type:

Article

A pathologist's primer on implementing new standard-of-care molecular biomarker testing for precision prostate cancer management.

Published in:

American Journal of Clinical Pathology, 2025, v. 163, n. 5, p. 649, doi. 10.1093/ajcp/aqae186

By:

Smith, Steven C;
Melson, John W;
Quillin, John M;
Hiemenz, Matthew C;
Tomlins, Scott A;
Wobker, Sara E

Publication type:

Article

Phosphoproteomics Reveals L1CAM-Associated Signaling Networks in High-Grade Serous Ovarian Carcinoma: Implications for Radioresistance and Tumorigenesis.

Published in:

International Journal of Molecular Sciences, 2025, v. 26, n. 10, p. 4585, doi. 10.3390/ijms26104585

By:

Todorov, Tihomir Zh;
Coelho, Ricardo;
Jacob, Francis;
Heinzelmann-Schwarz, Viola;
Schibli, Roger;
Béhé, Martin;
Grünberg, Jürgen;
Grzmil, Michal

Publication type:

Article

C1QBP Modulates DNA Damage Response and Radiosensitivity in Hepatocellular Carcinoma by Regulating NF-κB Activity.

Published in:

International Journal of Molecular Sciences, 2025, v. 26, n. 10, p. 4513, doi. 10.3390/ijms26104513

By:

Zhou, Haitao;
Wu, Yanjin;
Meng, Jiahui;
Zhao, Xiaotong;
Hou, Yujia;
Wang, Qin;
Liu, Yang

Publication type:

Article

Beyond Trypanosoma cruzi : LINE-1 Activation as a Driver of Chronic Inflammation in Chagas Disease.

Published in:

International Journal of Molecular Sciences, 2025, v. 26, n. 10, p. 4466, doi. 10.3390/ijms26104466

By:

Dias, Marina;
Moraes, Aline;
Shiroma, Tatiana;
Pessoa, Vitória;
Ermoges, Antonio;
Vital, Tamires;
Hagström, Luciana;
de Sousa, Davi;
de Castro, Márcio;
Dallago, Bruno;
Bastos, Izabela Marques Dourado;
Nitz, Nadjar;
Hecht, Mariana

Publication type:

Article

Biomimetic Hierarchical Construction of Anti‐Tumor Polyoxopalladates for Cancer Therapy.

Published in:

Angewandte Chemie, 2025, v. 137, n. 23, p. 1, doi. 10.1002/ange.202505564

By:

Zhao, Yue;
Liu, Zheran;
Qin, Zijian;
Wen, Qinlong;
Du, Jing;
Ren, Xiang‐Yu;
Chen, Chao‐Qin;
Peng, Xingchen;
Kortz, Ulrich;
Yang, Peng

Publication type:

Article

A Nucleus‐Targeting Ruthenium(II) Complex Induces DNA Condensation in Cisplatin‐Resistant Tumor Cells.

Published in:

Angewandte Chemie, 2025, v. 137, n. 23, p. 1, doi. 10.1002/ange.202504970

By:

Zhou, Ying;
Xiong, Kai;
Feng, Tao;
Wu, Xianbo;
Liang, Jinzhe;
Chen, Yu;
Chao, Hui

Publication type:

Article

Bioprospecting potential genetic biomarkers of gallbladder cancer.

Published in:

Molecular Biology Reports, 2025, v. 52, n. 1, p. 1, doi. 10.1007/s11033-025-10607-y

By:

Dixit, Ruhi;
Pandey, Manoj;
Shukla, Vijay Kumar

Publication type:

Article

Disruption of ATR Signaling by Epstein–Barr Virus Latent Membrane Protein 1 Sensitizes Nasopharyngeal Carcinoma Cells to Cisplatin.

Published in:

Journal of Medical Virology, 2025, v. 97, n. 5, p. 1, doi. 10.1002/jmv.70407

By:

Zarkovic, Gabriella;
Ziegler, Phillip;
Lee, Jennifer Hye‐Rim;
Dresden, Brooke;
Kumar, Amit;
Shuda, Masahiro;
Bäckerholm, Alan;
Shair, Kathy Ho Yen

Publication type:

Article

Clinical approaches to overcome PARP inhibitor resistance.

Published in:

Molecular Cancer, 2025, v. 24, n. 1, p. 1, doi. 10.1186/s12943-025-02355-1

By:

Zou, Yutian;
Zhang, Hanqi;
Chen, Pangzhou;
Tang, Jiayi;
Yang, Siwei;
Nicot, Christophe;
Guan, Ziyun;
Li, Xing;
Tang, Hailin

Publication type:

Article

淫羊藿素靶向 P53 调控 DNA 损伤修复和 FOXO 信号通路抑制胶质瘤细胞生长.

Published in:

Chinese Journal of Biochemistry & Molecular Biology, 2025, v. 41, n. 5, p. 753, doi. 10.13865/j.cnki.cjbmb.2025.03.1347

By:

罗智琼;
汪卓逸;
汪永平;
陈小忠;
余佳;
程莎;
昝宁宁;
孙宝飞;
骆衡

Publication type:

Article

ATR Deficiency Impairs DNA Damage Repair and Accelerates Cellular Senescence in Bovine Mammary Epithelial Cells, Leading to Lactation Dysfunction.

Published in:

Animals (2076-2615), 2025, v. 15, n. 10, p. 1419, doi. 10.3390/ani15101419

By:

Zhou, Qijun;
Geng, Zijian;
Lian, Shuai;
Wang, Jianfa;
Wu, Rui

Publication type:

Article

Functions, interactions and prognostic role of POLE: a bioinformatics analysis.

Published in:

Journal of Gynecologic Oncology, 2025, v. 36, n. 3, p. 1, doi. 10.3802/jgo.2025.36.e45

By:

Carvajal-Veloza, Jonathan;
Galindo-Morales, Fredy;
Gutierrez-Castañeda, Luz Dary

Publication type:

Article

CHD1L in cancer and beyond: structure, oncogenic functions, and therapeutic potential.

Published in:

Journal of Experimental & Clinical Cancer Research (17569966), 2025, v. 44, n. 1, p. 1, doi. 10.1186/s13046-025-03428-1

By:

Clune, Sophia;
Awolade, Paul;
Esquer, Hector;
Zhou, Qiong;
LaBarbera, Daniel V.

Publication type:

Article

Co-inhibition of Notch1 and ChK1 triggers genomic instability and melanoma cell death increasing the lifespan of mice bearing melanoma brain metastasis.

Published in:

Journal of Experimental & Clinical Cancer Research (17569966), 2025, v. 44, n. 1, p. 1, doi. 10.1186/s13046-025-03411-w

By:

Thakur, Varsha;
Thakur, Vijay S.;
Wang, Dazhi;
de Freitas, Juliano Tiburcio;
Bianchi, Anna;
Nivelo, Luis Alberto;
Umland, Oliver;
Welford, Scott M.;
Bedogni, Barbara

Publication type:

Article

Complex interactions between the DNA-damage response and mammalian telomeres.

Published in:

Nature Structural & Molecular Biology, 2015, v. 22, n. 11, p. 859, doi. 10.1038/nsmb.3092

By:

Arnoult, Nausica;
Karlseder, Jan

Publication type:

Article

A dynamic DNA-repair complex observed by correlative single-molecule nanomanipulation and fluorescence.

Published in:

Nature Structural & Molecular Biology, 2015, v. 22, n. 6, p. 452, doi. 10.1038/nsmb.3019

By:

Graves, Evan T;
Duboc, Camille;
Fan, Jun;
Stransky, François;
Leroux-Coyau, Mathieu;
Strick, Terence R

Publication type:

Article

Evidence that processing of ribonucleotides in DNA by topoisomerase 1 is leading-strand specific.

Published in:

Nature Structural & Molecular Biology, 2015, v. 22, n. 4, p. 291, doi. 10.1038/nsmb.2989

By:

Williams, Jessica S;
Clausen, Anders R;
Lujan, Scott A;
Marjavaara, Lisette;
Clark, Alan B;
Burgers, Peter M;
Chabes, Andrei;
Kunkel, Thomas A

Publication type:

Article

K63 polyubiquitination is a new modulator of the oxidative stress response.

Published in:

Nature Structural & Molecular Biology, 2015, v. 22, n. 2, p. 116, doi. 10.1038/nsmb.2955

By:

Silva, Gustavo M;
Finley, Daniel;
Vogel, Christine

Publication type:

Article

Structure and mechanism of action of the BRCA2 breast cancer tumor suppressor.

Published in:

Nature Structural & Molecular Biology, 2014, v. 21, n. 11, p. 962, doi. 10.1038/nsmb.2899

By:

Shahid, Taha;
Soroka, Joanna;
Kong, Eric H;
Malivert, Laurent;
McIlwraith, Michael J;
Pape, Tillmann;
West, Stephen C;
Zhang, Xiaodong

Publication type:

Article

SET-ting the stage for DNA repair.

Published in:

Nature Structural & Molecular Biology, 2014, v. 21, n. 8, p. 655, doi. 10.1038/nsmb.2866

By:

Jha, Deepak K;
Pfister, Sophia X;
Humphrey, Timothy C;
Strahl, Brian D

Publication type:

Article

Transcriptionally active chromatin recruits homologous recombination at DNA double-strand breaks.

Published in:

Nature Structural & Molecular Biology, 2014, v. 21, n. 4, p. 366, doi. 10.1038/nsmb.2796

By:

Aymard, François;
Bugler, Beatrix;
Schmidt, Christine K;
Guillou, Emmanuelle;
Caron, Pierre;
Briois, Sébastien;
Iacovoni, Jason S;
Daburon, Virginie;
Miller, Kyle M;
Jackson, Stephen P;
Legube, Gaëlle

Publication type:

Article

Two-way communications between ubiquitin-like modifiers and DNA.

Published in:

Nature Structural & Molecular Biology, 2014, v. 21, n. 4, p. 317, doi. 10.1038/nsmb.2805

By:

Ulrich, Helle D

Publication type:

Article

Structural and mechanistic insight into Holliday-junction dissolution by Topoisomerase IIIα and RMI1.

Published in:

Nature Structural & Molecular Biology, 2014, v. 21, n. 3, p. 261, doi. 10.1038/nsmb.2775

By:

Bocquet, Nicolas;
Bizard, Anna H;
Abdulrahman, Wassim;
Larsen, Nicolai B;
Faty, Mahamadou;
Cavadini, Simone;
Bunker, Richard D;
Kowalczykowski, Stephen C;
Cejka, Petr;
Hickson, Ian D;
Thomä, Nicolas H

Publication type:

Article

A mediator methylation mystery: JMJD1C demethylates MDC1 to regulate DNA repair.

Published in:

Nature Structural & Molecular Biology, 2013, v. 20, n. 12, p. 1346, doi. 10.1038/nsmb.2729

By:

Lu, Jian;
Matunis, Michael J

Publication type:

Article

Sensing KATastrophe.

Published in:

Nature Structural & Molecular Biology, 2013, v. 20, n. 7, p. 775, doi. 10.1038/nsmb.2633

By:

Moorefield, Beth

Publication type:

Article

Preferential D-loop extension by a translesion DNA polymerase underlies error-prone recombination.

Published in:

Nature Structural & Molecular Biology, 2013, v. 20, n. 6, p. 748, doi. 10.1038/nsmb.2573

By:

Pomerantz, Richard T;
Kurth, Isabel;
Goodman, Myron F;
O'Donnell, Mike E

Publication type:

Article

Regulation of Mus81-Eme1 Holliday junction resolvase in response to DNA damage.

Published in:

Nature Structural & Molecular Biology, 2013, v. 20, n. 5, p. 598, doi. 10.1038/nsmb.2550

By:

Dehé, Pierre-Marie;
Coulon, Stéphane;
Scaglione, Sarah;
Shanahan, Paul;
Takedachi, Arato;
Wohlschlegel, James A;
Yates, John R;
Llorente, Bertrand;
Russell, Paul;
Gaillard, Pierre-Henri L

Publication type:

Article

Acetylation limits 53BP1 association with damaged chromatin to promote homologous recombination.

Published in:

Nature Structural & Molecular Biology, 2013, v. 20, n. 3, p. 317, doi. 10.1038/nsmb.2499

By:

Tang, Jiangbo;
Cho, Nam Woo;
Cui, Gaofeng;
Manion, Erica M;
Shanbhag, Niraj M;
Botuyan, Maria Victoria;
Mer, Georges;
Greenberg, Roger A

Publication type:

Article

LEDGF (p75) promotes DNA-end resection and homologous recombination.

Published in:

Nature Structural & Molecular Biology, 2012, v. 19, n. 8, p. 803, doi. 10.1038/nsmb.2314

By:

Daugaard, Mads;
Baude, Annika;
Fugger, Kasper;
Povlsen, Lou Klitgaard;
Beck, Halfdan;
Sørensen, Claus Storgaard;
Petersen, Nikolaj H T;
Sorensen, Poul H B;
Lukas, Claudia;
Bartek, Jiri;
Lukas, Jiri;
Rohde, Mikkel;
Jäättelä, Marja

Publication type:

Article

Duplex interrogation by a direct DNA repair protein in search of base damage.

Published in:

Nature Structural & Molecular Biology, 2012, v. 19, n. 7, p. 671, doi. 10.1038/nsmb.2320

By:

Yi, Chengqi;
Chen, Baoen;
Qi, Bo;
Zhang, Wen;
Jia, Guifang;
Zhang, Liang;
Li, Charles J;
Dinner, Aaron R;
Yang, Cai-Guang;
He, Chuan

Publication type:

Article

A rule of seven in Watson-Crick base-pairing of mismatched sequences.

Published in:

Nature Structural & Molecular Biology, 2012, v. 19, n. 6, p. 623, doi. 10.1038/nsmb.2294

By:

Cisse, Ibrahim I;
Kim, Hajin;
Ha, Taekjip

Publication type:

Article

Structure of mammalian poly(ADP-ribose) glycohydrolase reveals a flexible tyrosine clasp as a substrate-binding element.

Published in:

Nature Structural & Molecular Biology, 2012, v. 19, n. 6, p. 653, doi. 10.1038/nsmb.2305

By:

Kim, In-Kwon;
Kiefer, James R;
Ho, Chris M W;
Stegeman, Roderick A;
Classen, Scott;
Tainer, John A;
Ellenberger, Tom

Publication type:

Article

Structure and mechanism of the UvrA-UvrB DNA damage sensor.

Published in:

Nature Structural & Molecular Biology, 2012, v. 19, n. 3, p. 291, doi. 10.1038/nsmb.2240

By:

Pakotiprapha, Danaya;
Samuels, Martin;
Shen, Koning;
Hu, Johnny H;
Jeruzalmi, David

Publication type:

Article

ABC ATPase signature helices in Rad50 link nucleotide state to Mre11 interface for DNA repair.

Published in:

Nature Structural & Molecular Biology, 2012, v. 19, n. 3, p. 364, doi. 10.1038/nsmb0312-364a

By:

Williams, Gareth J;
Williams, R Scott;
Williams, Jessica S;
Moncalian, Gabriel;
Arvai, Andrew S;
Limbo, Oliver;
Guenther, Grant;
SilDas, Soumita;
Hammel, Michal;
Russell, Paul;
Tainer, John A

Publication type:

Article

Mechanism of mismatch recognition revealed by human MutS? bound to unpaired DNA loops.

Published in:

Nature Structural & Molecular Biology, 2012, v. 19, n. 1, p. 72, doi. 10.1038/nsmb.2175

By:

Gupta, Shikha;
Gellert, Martin;
Yang, Wei

Publication type:

Article