Results
Title

Coding variants of TLR2 and TLR4 genes do not substantially contribute to prosthetic joint infection.

Authors

Mrazek, Frantisek; Gallo, Jiri; Stahelova, Anna; Petrek, Martin

Abstract

Objective and design: Prosthetic joint infection (PJI) is a severe complication of total joint arthroplasty (TJA). We conducted a genetic association study that investigated whether selected coding variants of the genes for Toll-like receptors (TLR)2 and TLR4 may contribute to genetic susceptibility for PJI. Subjects and methods: In total, 350 patients with TJA (98 with PJI/252 without PJI), and 189 unrelated healthy Czech individuals without TJA were enrolled in our study. Three missense polymorphisms of the genes encoding for TLR2 ( TLR2 R753Q, rs5743708) and TLR4 ( TLR4 D299G, rs4986790 and T399I, rs4986791) were genotyped by 'TaqMan' assay. Results: The frequencies of less common variants for the investigated TLR2/TLR4 polymorphisms in healthy individuals were similar to those observed in other Caucasian populations. Importantly, the distribution of TLR2/TLR4 genotype alleles did not differ between the patients with PJI and the control groups of patients with nonseptic prostheses/healthy individuals. Conclusion: Our data suggest that structural genetic variants of the receptors TLR2 and TLR4 do not substantially affect the risk of prosthetic joint infection.

Subjects

ARTHROPLASTY; PROSTHETICS; GENES; TOLL-like receptors; GENETICS; CONTROL groups

Publication

Inflammation Research, 2013, Vol 62, Issue 5, p483

ISSN

1023-3830

Publication type

Academic Journal

DOI

10.1007/s00011-013-0601-8