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- Title
Suppressive effects of furonaphthoquinone NFD-37 on the production of lipopolysaccharide-inducible inflammatory mediators in macrophages RAW 264.7.
- Authors
Min-Hee, Kim; Hyun-Mo, Shin; Yong Rok, Lee; Eun Yong, Chung; Yoon Sook, Chang; Kyung Rak, Min; Youngsoo, Kim
- Abstract
2-Methyl-2-(2-methylpropenyl)-2,3-dihydronaphthoquinone[2,3- b]furan-4,9-dione (NFD-37) is a synthetic furonaphthoquinone compound. In this study, we determined that NFD-37 could inhibit the lipopolysaccharide (LPS)-induced production of inflammatory mediators in macrophages RAW 264.7. This compound inhibited LPS-induced nitric oxide (NO) or prostaglandin (PG) E2 production in dose-dependent manners, with IC50 values of 7.2 μM and 5.3 μM, respectively. As the positive controls, pyrrolidine dithiocarbamate (30 μM) exhibited a 57% inhibition of NO production, and NS-398 (1 μM) manifested a 48% inhibition of PGE2 production. The inhibitory effects of NFD-37 on NO and PGE2 production were determined to occur in conjunction with the suppression of inducible NO synthase or cyclooxygenase-2 expression. NFD-37 also inhibited the production of LPS-inducible tumor necrosis factor-α, interleukin (IL)-1β and IL-6, at IC50 values of 4.8–8.9 μM. We also determined the anti-inflammatory efficacy of NFD-37 using carrageenin-induced paw edema in experimental mice.
- Publication
Archives of Pharmacal Research, 2005, Vol 28, Issue 10, p1170
- ISSN
0253-6269
- Publication type
Academic Journal
- DOI
10.1007/BF02972982