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- Title
Suppressive effects of young radish cultivated with sulfur on growth and metastasis of B16-F10 melanoma cells.
- Authors
Kim, Soo-Jin; Kim, Byung-Sam; Kyung, Tae-Wook; Lee, Sang-Chul; Rho, Chi-Woong; Choi, Kyung-Rak; Hwang, Hae-Jun; Choi, Hye-Seon
- Abstract
The oral administration of extracts of young radishes cultivated with sulfur after intravenous tumor cell injection achieved a marked reduction of pulmonary colonization in mice. Treatment of the mice with extracts of young radish cultivated with sulfur did not show any increase in the number of CD8 or NK T cells in the spleen, indicating no influence on host immunity. Sulforaphane, which could be a candidate for an active compound from young radishes cultivated with sulfur, inhibited cell growth of B16-F10 melanoma cells. In addition, extracts of the young radish cultivated with sulfur-fed group showed enhanced quinine reductase (QR) activities in the liver and lung and a slight increase of glutathione S-transferase (GST) activity in the liver. These results suggested that the administration of extracts of young radishes cultivated with sulfur suppressed pulmonary tumorigenesis, possibly due to increased activity of detoxification enzymes in the liver and lung, and partly due to cell cytotoxicity.
- Publication
Archives of Pharmacal Research, 2006, Vol 29, Issue 3, p235
- ISSN
0253-6269
- Publication type
Academic Journal
- DOI
10.1007/BF02969399