The article in Small Methods discusses the nanoscale-confined synthesis of 2D metal compounds for electrochemical applications, focusing on materials like TMDs, LDHs, MXenes, and their hybrids. Kim, Lee, and their colleagues provide a comprehensive overview of recent advancements in structural control and applications of these materials, highlighting their unique properties and potential challenges for high-performance electrochemical systems. The authors delve into the physicochemical characteristics of these materials, offering insights into future research directions in this field.