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No relation between docetaxel administration route and high‐grade diarrhea incidence.
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- Pharmacology Research & Perspectives, 2020, v. 8, n. 4, p. 1, doi. 10.1002/prp2.633
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- Publication type:
- Article
Drug Transporters ABCB1 (P-gp) and OATP, but not Drug-Metabolizing Enzyme CYP3A4, Affect the Pharmacokinetics of the Psychoactive Alkaloid Ibogaine and its Metabolites.
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- Frontiers in Pharmacology, 2022, v. 13, p. 1, doi. 10.3389/fphar.2022.855000
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- Publication type:
- Article
Evidence of promiscuous endothelial binding by P lasmodium falciparum-infected erythrocytes.
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- Cellular Microbiology, 2014, v. 16, n. 5, p. 701, doi. 10.1111/cmi.12270
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- Article
ABCB1 and ABCG2 Control Brain Accumulation and Intestinal Disposition of the Novel ROS1/TRK/ALK Inhibitor Repotrectinib, While OATP1A/1B, ABCG2, and CYP3A Limit Its Oral Availability.
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- Pharmaceutics, 2021, v. 13, n. 11, p. 1761, doi. 10.3390/pharmaceutics13111761
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- Article
P-Glycoprotein (MDR1/ABCB1) Restricts Brain Accumulation of the Novel EGFR Inhibitor EAI045 and Oral Elacridar Coadministration Enhances Its Brain Accumulation and Oral Exposure.
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- Pharmaceuticals (14248247), 2022, v. 15, n. 9, p. N.PAG, doi. 10.3390/ph15091124
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- Publication type:
- Article
Predictiveness of the Human-CYP3A4-Transgenic Mouse Model (Cyp3aXAV) for Human Drug Exposure of CYP3A4-Metabolized Drugs.
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- Pharmaceuticals (14248247), 2022, v. 15, n. 7, p. N.PAG, doi. 10.3390/ph15070860
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- Publication type:
- Article
P-Glycoprotein (ABCB1/MDR1) and BCRP (ABCG2) Limit Brain Accumulation and Cytochrome P450-3A (CYP3A) Restricts Oral Exposure of the RET Inhibitor Selpercatinib (RETEVMO).
- Published in:
- Pharmaceuticals (14248247), 2021, v. 14, n. 11, p. 1087, doi. 10.3390/ph14111087
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- Article
The Mechanism-Based Inactivation of CYP3A4 by Ritonavir: What Mechanism?
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- International Journal of Molecular Sciences, 2022, v. 23, n. 17, p. 9866, doi. 10.3390/ijms23179866
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- Article
P-glycoprotein ABCB1: a major player in drug handling by mammals.
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- 2013
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- Publication type:
- journal article
P-glycoprotein ABCB1: a major player in drug handling by mammals.
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- Journal of Clinical Investigation, 2013, v. 123, n. 10, p. 4131, doi. 10.1172/JCI70430
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- Article
Complete OATP1B1 and OATP1B3 deficiency causes human Rotor syndrome by interrupting conjugated bilirubin reuptake into the liver.
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- Journal of Clinical Investigation, 2012, v. 122, n. 2, p. 519, doi. 10.1172/JCI59526
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- Publication type:
- Article
Organic anion transporting polypeptide 1a/1b-knockout mice provide insights into hepatic handling of bilirubin, bile acids, and drugs.
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- 2010
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- Publication type:
- journal article
Knockout of cytochrome P450 3A yields new mouse models for understanding xenobiotic metabolism.
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- 2007
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- Publication type:
- journal article
Hepatobiliary and intestinal clearance of amphiphilic cationic drugs in mice in which both mdr1a and mdr1b genes have been disrupted.
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- British Journal of Pharmacology, 1998, v. 124, n. 2, p. 416, doi. 10.1038/sj.bjp.0701845
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- Publication type:
- Article
Binding properties of monoclonal antibodies recognizing external epitopes of the human MDR1 P-glycoprotein.
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- International Journal of Cancer, 1993, v. 55, n. 3, p. 478, doi. 10.1002/ijc.2910550326
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- Publication type:
- Article
P-glycoprotein (MDR1/ABCB1) Restricts Brain Penetration of the Main Active Heroin Metabolites 6-monoacetylmorphine (6-MAM) and Morphine in Mice.
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- Pharmaceutical Research, 2023, v. 40, n. 8, p. 1885, doi. 10.1007/s11095-023-03545-6
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- Publication type:
- Article
Metabolome Analysis Reveals Dermal Histamine Accumulation in Murine Dermatitis Provoked by Genetic Deletion of P-Glycoprotein and Breast Cancer Resistance Protein.
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- Pharmaceutical Research, 2019, v. 36, n. 11, p. 1, doi. 10.1007/s11095-019-2695-3
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- Publication type:
- Article
The breast cancer resistance protein BCRP (ABCG2) concentrates drugs and carcinogenic xenotoxins into milk.
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- Nature Medicine, 2005, v. 11, n. 2, p. 127, doi. 10.1038/nm1186
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- Publication type:
- Article
Extrahepatic metabolism of ibrutinib.
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- Investigational New Drugs, 2021, v. 39, n. 1, p. 1, doi. 10.1007/s10637-020-00970-x
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- Publication type:
- Article
Drug disposition as determined by the interplay between drug-transporting and drug-metabolizing systems.
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- Journal of Biochemical & Molecular Toxicology, 1999, v. 13, n. 3/4, p. 219, doi. 10.1002/(SICI)1099-0461(1999)13:3/4<219::AID-JBT13>3.0.CO;2-Z
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- Publication type:
- Article
Role of acetylcholine and polyspecific cation transporters in serotonin-induced bronchoconstriction in the mouse.
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- Respiratory Research, 2006, v. 7, p. 65, doi. 10.1186/1465-9921-7-65
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- Publication type:
- Article
Transport of Topoisomerase I Inhibitors by the Breast Cancer Resistance Protein: Potential Clinical Implications.
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- Annals of the New York Academy of Sciences, 2000, v. 922, n. 1, p. 188, doi. 10.1111/j.1749-6632.2000.tb07037.x
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- Publication type:
- Article
Impact of loperamide on the pharmacokinetics and tissue disposition of ritonavir-boosted oral docetaxel therapy; a preclinical assessment.
- Published in:
- Cancer Chemotherapy & Pharmacology, 2024, v. 94, n. 1, p. 79, doi. 10.1007/s00280-024-04662-8
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- Publication type:
- Article
Availability of PSC833, a substrate and inhibitor of P-glycoproteins, in various concentrations of serum.
- Published in:
- 1998
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- Publication type:
- journal article
Altered pharmacokinetics of vinblastine in mdr1a p-glycoprotein-deficient mice.
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- JNCI: Journal of the National Cancer Institute, 1996, v. 88, n. 14, p. 994, doi. 10.1093/jnci/88.14.994
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- Publication type:
- Article
Transport of biogenic amine neurotransmitters at the mouse blood-retina and blood-brain barriers by uptake1 and uptake2.
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- Journal of Cerebral Blood Flow & Metabolism, 2012, v. 32, n. 11, p. 1989, doi. 10.1038/jcbfm.2012.109
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- Publication type:
- Article
Targeted disruption of organic cation transporter 3 (Oct3) ameliorates ischemic brain damage through modulating histamine and regulatory T cells.
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- Journal of Cerebral Blood Flow & Metabolism, 2012, v. 32, n. 10, p. 1897, doi. 10.1038/jcbfm.2012.92
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- Publication type:
- Article
Intestinal cytochrome P450 3A plays an important role in the regulation of detoxifying systems in the liver.
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- FASEB Journal, 2009, v. 23, n. 1, p. 224, doi. 10.1096/fj.08-114876
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- Publication type:
- Article
Breast cancer resistance protein (Bcrp1/Abcg2) reduces systemic exposure of the dietary carcinogens aflatoxin B1, IQ and Trp-P-1 but also mediates their secretion into breast milk.
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- Carcinogenesis, 2006, v. 27, n. 1, p. 123
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- Publication type:
- Article
MRP2 (ABCC2) transports taxanes and confers paclitaxel resistance and both processes are stimulated by probenecid.
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- International Journal of Cancer, 2005, v. 116, n. 5, p. 824, doi. 10.1002/ijc.21013
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- Publication type:
- Article
Development and validation of an HPLC–MS/MS method to quantify the KRAS inhibitor adagrasib in mouse plasma and tissue‐related matrices.
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- Biomedical Chromatography, 2023, v. 37, n. 11, p. 1, doi. 10.1002/bmc.5720
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- Publication type:
- Article
Bioanalytical assay for the quantification of the tyrosine kinase inhibitor EAI045 and its major metabolite PIA in mouse plasma and tissue homogenates using liquid chromatography–tandem mass spectrometry.
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- Biomedical Chromatography, 2022, v. 36, n. 11, p. 1, doi. 10.1002/bmc.5457
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- Article
Liquid chromatography-tandem mass spectrometric assay for the multikinase inhibitor regorafenib in plasma.
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- Biomedical Chromatography, 2014, v. 28, n. 10, p. 1366, doi. 10.1002/bmc.3176
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- Publication type:
- Article
Combined quantification of paclitaxel, docetaxel and ritonavir in human feces and urine using LC-MS/MS.
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- Biomedical Chromatography, 2014, v. 28, n. 2, p. 302, doi. 10.1002/bmc.3021
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- Publication type:
- Article
Pharmacokinetics of docetaxel and ritonavir after oral administration of ModraDoc006/r in patients with prostate cancer versus patients with other advanced solid tumours.
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- 2021
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- Publication type:
- journal article
Cytochrome P450 3A4, 3A5, and 2C8 expression in breast, prostate, lung, endometrial, and ovarian tumors: relevance for resistance to taxanes.
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- 2019
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- Publication type:
- journal article
Absence of N-linked glycosylation does not affect plasma membrane localization of breast cancer resistance protein (BCRP/ABCG2).
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- 2005
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- Publication type:
- journal article
OATP1A/1B, CYP3A, ABCB1, and ABCG2 limit oral availability of the NTRK inhibitor larotrectinib, while ABCB1 and ABCG2 also restrict its brain accumulation.
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- 2020
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- Publication type:
- journal article
P‐glycoprotein (MDR1/ABCB1) controls brain accumulation and intestinal disposition of the novel TGF‐β signaling pathway inhibitor galunisertib.
- Published in:
- International Journal of Cancer, 2020, v. 146, n. 6, p. 1631, doi. 10.1002/ijc.32568
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- Publication type:
- Article
P‐glycoprotein (MDR1/ABCB1) restricts brain accumulation and cytochrome P450‐3A (CYP3A) limits oral availability of the novel ALK/ROS1 inhibitor lorlatinib.
- Published in:
- International Journal of Cancer, 2018, v. 143, n. 8, p. 2029, doi. 10.1002/ijc.31582
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- Publication type:
- Article
Ritonavir inhibits intratumoral docetaxel metabolism and enhances docetaxel antitumor activity in an immunocompetent mouse breast cancer model.
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- International Journal of Cancer, 2016, v. 138, n. 3, p. 758, doi. 10.1002/ijc.29812
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- Publication type:
- Article
Human OATP1B1, OATP1B3 and OATP1A2 can mediate the in vivo uptake and clearance of docetaxel.
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- International Journal of Cancer, 2015, v. 136, n. 1, p. 225, doi. 10.1002/ijc.28970
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- Publication type:
- Article
In vivo disposition of doxorubicin is affected by mouse Oatp1a/1b and human OATP1A/1B transporters.
- Published in:
- International Journal of Cancer, 2014, v. 135, n. 7, p. 1700, doi. 10.1002/ijc.28797
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- Publication type:
- Article
Increased oral availability and brain accumulation of the ALK inhibitor crizotinib by coadministration of the P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) inhibitor elacridar.
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- International Journal of Cancer, 2014, v. 134, n. 6, p. 1484, doi. 10.1002/ijc.28475
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- Publication type:
- Article
P-glycoprotein and cytochrome P450 3A act together in restricting the oral bioavailability of paclitaxel.
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- International Journal of Cancer, 2013, v. 132, n. 10, p. 2439, doi. 10.1002/ijc.27912
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- Publication type:
- Article
Individual and combined roles of CYP3A, P-glycoprotein (MDR1/ABCB1) and MRP2 (ABCC2) in the pharmacokinetics of docetaxel.
- Published in:
- International Journal of Cancer, 2010, v. 127, n. 12, p. 2959, doi. 10.1002/ijc.25279
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- Publication type:
- Article
Clinical Pharmacokinetics and Pharmacodynamics of the Cyclin-Dependent Kinase 4 and 6 Inhibitors Palbociclib, Ribociclib, and Abemaciclib.
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- Clinical Pharmacokinetics, 2020, v. 59, n. 12, p. 1501, doi. 10.1007/s40262-020-00930-x
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- Publication type:
- Article
Predictability of human exposure by human‐CYP3A4‐transgenic mouse models: A meta‐analysis.
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- CTS: Clinical & Translational Science, 2024, v. 17, n. 1, p. 1, doi. 10.1111/cts.13668
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- Publication type:
- Article
Development and validation of a bioanalytical method for the quantification of the CDK4/6 inhibitors abemaciclib, palbociclib, and ribociclib in human and mouse matrices using liquid chromatography-tandem mass spectrometry.
- Published in:
- Analytical & Bioanalytical Chemistry, 2019, v. 411, n. 20, p. 5331, doi. 10.1007/s00216-019-01932-w
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- Article
Changes in dipole membrane potential at the mouse blood–brain barrier enhance the transport of <sup>99m</sup>Technetium Sestamibi more than inhibiting Abcb1, Abcc1, or Abcg2.
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- Journal of Neurochemistry, 2009, v. 108, n. 3, p. 767, doi. 10.1111/j.1471-4159.2008.05832.x
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- Article