Works matching AU Tawfik, Dan S.

Results: 77

An Ancient Fingerprint Indicates the Common Ancestry of Rossmann-Fold Enzymes Utilizing Different Ribose-Based Cofactors.

Published in:

PLoS Biology, 2016, v. 14, n. 3, p. 1, doi. 10.1371/journal.pbio.1002396

By:

Laurino, Paola;
Tóth-Petróczy, Ágnes;
Meana-Pañeda, Rubén;
Lin, Wei;
Truhlar, Donald G.;
Tawfik, Dan S.

Publication type:

Article

A Personal Reflection on the Chemistry‐Biology Interface.

Published in:

Israel Journal of Chemistry, 2019, v. 59, n. 1/2, p. 23, doi. 10.1002/ijch.201900008

By:

Tawfik, Dan S.

Publication type:

Article

Investigating the target recognition of DNA cytosine‐5 methyltransferase HhaI by library selection using in vitro compartmentalisation.

Published in:

Nucleic Acids Research, 2002, v. 30, n. 22, p. 4937, doi. 10.1093/nar/gkf617

By:

Lee, Yin‐Fai;
Tawfik, Dan S.;
Griffiths, Andrew D.

Publication type:

Article

Promiscuous methylation of non‐canonical DNA sites by HaeIII methyltransferase.

Published in:

Nucleic Acids Research, 2002, v. 30, n. 17, p. 3880, doi. 10.1093/nar/gkf507

By:

Cohen, Helen M.;
Tawfik, Dan S.;
Griffiths, Andrew D.

Publication type:

Article

A mixture of three engineered phosphotriesterases enables rapid detoxification of the entire spectrum of known threat nerve agents.

Published in:

PEDS: Protein Engineering, Design & Selection, 2019, v. 32, n. 4, p. 169, doi. 10.1093/protein/gzz039

By:

Despotović, Dragana;
Aharon, Einav;
Dubovetskyi, Artem;
Leader, Haim;
Ashani, Yacov;
Tawfik, Dan S

Publication type:

Article

Overcoming an optimization plateau in the directed evolution of highly efficient nerve agent bioscavengers.

Published in:

PEDS: Protein Engineering, Design & Selection, 2017, v. 30, n. 4, p. 333, doi. 10.1093/protein/gzx003

By:

Goldsmith, Moshe;
Aggarwal, Nidhi;
Ashani, Yacov;
Jubran, Halim;
Greisen, Per Jr.;
Ovchinnikov, Sergey;
Leader, Haim;
Baker, David;
Sussman, Joel L.;
Goldenzweig, Adi;
Fleishman, Sarel J.;
Tawfik, Dan S.

Publication type:

Article

Assessing the prediction fidelity of ancestral reconstruction by a library approach.

Published in:

PEDS: Protein Engineering, Design & Selection, 2015, v. 28, n. 11, p. 507, doi. 10.1093/protein/gzv038

By:

Bar-Rogovsky, Hagit;
Stern, Adi;
Penn, Osnat;
Kobl, Iris;
Pupko, Tal;
Tawfik, Dan S.

Publication type:

Article

TRINS: a method for gene modification by randomized tandem repeat insertions.

Published in:

PEDS: Protein Engineering, Design & Selection, 2012, v. 25, n. 9, p. 437, doi. 10.1093/protein/gzs023

By:

Kipnis, Yakov;
Dellus-Gur, Eynat;
Tawfik, Dan S.

Publication type:

Article

Functional β-propeller lectins by tandem duplications of repetitive units.

Published in:

PEDS: Protein Engineering, Design & Selection, 2011, v. 24, n. 1/2, p. 185, doi. 10.1093/protein/gzq053

By:

Yadid, Itamar;
Tawfik, Dan S.

Publication type:

Article

Avoiding and controlling double transformation artifacts.

Published in:

PEDS: Protein Engineering, Design & Selection, 2007, v. 20, n. 7, p. 315, doi. 10.1093/protein/gzm026

By:

Moshe Goldsmith;
Csaba Kiss;
Andrew R.M. Bradbury;
Dan S. Tawfik

Publication type:

Article

Incorporating Synthetic Oligonucleotides via Gene Reassembly (ISOR): a versatile tool for generating targeted libraries.

Published in:

PEDS: Protein Engineering, Design & Selection, 2007, v. 20, n. 5, p. 219, doi. 10.1093/protein/gzm014

By:

Asael Herman;
Dan S. Tawfik

Publication type:

Article

Altering the sequence specificity of HaeIII methyltransferase by directed evolution using in vitro compartmentalization.

Published in:

PEDS: Protein Engineering, Design & Selection, 2004, v. 17, n. 1, p. 3, doi. 10.1093/protein/gzh001

By:

Helen M. Cohen;
Dan S. Tawfik;
Andrew D. Griffiths

Publication type:

Article

Characterization of ancestral Fe/Mn superoxide dismutases indicates their cambialistic origin.

Published in:

Protein Science: A Publication of the Protein Society, 2022, v. 31, n. 10, p. 1, doi. 10.1002/pro.4423

By:

Valenti, Rosario;
Jabłońska, Jagoda;
Tawfik, Dan S.

Publication type:

Article

Uniform binding and negative catalysis at the origin of enzymes.

Published in:

Protein Science: A Publication of the Protein Society, 2022, v. 31, n. 8, p. 1, doi. 10.1002/pro.4381

By:

Noor, Elad;
Flamholz, Avi I.;
Jayaraman, Vijay;
Ross, Brian L.;
Cohen, Yair;
Patrick, Wayne M.;
Gruic‐Sovulj, Ita;
Tawfik, Dan S.

Publication type:

Article

Innovation and tinkering in the evolution of oxidases.

Published in:

Protein Science: A Publication of the Protein Society, 2022, v. 31, n. 5, p. 1, doi. 10.1002/pro.4310

By:

Jabłońska, Jagoda;
Tawfik, Dan S.

Publication type:

Article

Quantifying and understanding the fitness effects of protein mutations: Laboratory versus nature.

Published in:

2019

By:

Boucher, Jeffrey I.;
Bolon, Daniel N. A.;
Tawfik, Dan S.

Publication type:

Correction Notice

Following evolutionary paths to protein-protein interactions with high affinity and selectivity.

Published in:

Nature Structural & Molecular Biology, 2009, v. 16, n. 10, p. 1049, doi. 10.1038/nsmb.1670

By:

Levin, Kalia Bernath;
Dym, Orly;
Albeck, Shira;
Magdassi, Shlomo;
Keeble, Anthony H.;
Kleanthous, Colin;
Tawfik, Dan S.

Publication type:

Article

Corrigendum: Structure and evolution of the serum paraoxonase family of detoxifying and anti-atherosclerotic enzymes.

Published in:

2004

By:

Harel, Michal;
Aharoni, Amir;
Gaidukov, Leonid;
Brumshtein, Boris;
Khersonsky, Olga;
Meged, Ran;
Dvir, Hay;
Ravelli, Raimond B G;
McCarthy, Andrew;
Toker, Lilly;
Silman, Israel;
Sussman, Joel L;
Tawfik, Dan S

Publication type:

Correction Notice

Structure and evolution of the serum paraoxonase family of detoxifying and anti-atherosclerotic enzymes.

Published in:

Nature Structural & Molecular Biology, 2004, v. 11, n. 5, p. 412, doi. 10.1038/nsmb767

By:

Harel, Michal;
Aharoni, Amir;
Gaidukov, Leonid;
Brumshtein, Boris;
Khersonksy, Olga;
Meged, Ran;
Dvir, Hay;
Ravelli, Raimond B. G.;
McCarthy, Andrew;
Toker, Lilly;
Silman, Israel;
Sussman, Joel L.;
Tawfik, Dan S.

Publication type:

Article

Directed evolution of the rRNA methylating enzyme Cfr reveals molecular basis of antibiotic resistance.

Published in:

eLife, 2022, p. 1, doi. 10.7554/eLife.70017

By:

Tsai, Kaitlyn;
Stojković, Vanja;
Noda-Garcia, Lianet;
Young, Iris D.;
Myasnikov, Alexander G.;
Kleinman, Jordan;
Palla, Ali;
Floor, Stephen N.;
Frost, Adam;
Fraser, James S.;
Tawfik, Dan S.;
Fujimori, Danica Galonić

Publication type:

Article

Rescue of conformational dynamics in enzyme catalysis by directed evolution.

Published in:

Nature Communications, 2018, v. 9, n. 1, p. 1, doi. 10.1038/s41467-018-03562-9

By:

Otten, Renee;
Lin Liu;
Kenner, Lillian R.;
Clarkson, Michael W.;
Mavor, David;
Tawfik, Dan S.;
Kern, Dorothee;
Fraser, James S.

Publication type:

Article

Enzyme promiscuity and evolution in light of cellular metabolism.

Published in:

FEBS Journal, 2020, v. 287, n. 7, p. 1260, doi. 10.1111/febs.15296

By:

Tawfik, Dan S.

Publication type:

Article

How evolution shapes enzyme selectivity – lessons from aminoacyl‐tRNA synthetases and other amino acid utilizing enzymes.

Published in:

FEBS Journal, 2020, v. 287, n. 7, p. 1284, doi. 10.1111/febs.15199

By:

Tawfik, Dan S.;
Gruic‐Sovulj, Ita

Publication type:

Article

Diadenosine tetraphosphate (Ap4A) - an E. coli alarmone or a damage metabolite?

Published in:

FEBS Journal, 2017, v. 284, n. 14, p. 2194, doi. 10.1111/febs.14113

By:

Despotović, Dragana;
Brandis, Alexander;
Savidor, Alon;
Levin, Yishai;
Fumagalli, Laura;
Tawfik, Dan S.

Publication type:

Article

Systematic Mapping of Protein Mutational Space by Prolonged Drift Reveals the Deleterious Effects of Seemingly Neutral Mutations.

Published in:

PLoS Computational Biology, 2015, v. 11, n. 8, p. 1, doi. 10.1371/journal.pcbi.1004421

By:

Rockah-Shmuel, Liat;
Tóth-Petróczy, Ágnes;
Tawfik, Dan S.

Publication type:

Article

How Protein Stability and New Functions Trade Off.

Published in:

PLoS Computational Biology, 2008, v. 4, n. 2, p. 1, doi. 10.1371/journal.pcbi.1000002

By:

Tokuriki, Nobuhiko;
Stricher, Francois;
Serrano, Luis;
Tawfik, Dan S.

Publication type:

Article

Chromogenic and Fluorogenic Assays for the Lactonase Activity of Serum Paraoxonases.

Published in:

ChemBioChem, 2006, v. 7, n. 1, p. 49, doi. 10.1002/cbic.200500334

By:

Olga Khersonsky;
Dan S. Tawfik

Publication type:

Article

The molecular basis of phosphate discrimination in arsenate-rich environments.

Published in:

Nature, 2012, v. 491, n. 7422, p. 134, doi. 10.1038/nature11517

By:

Elias, Mikael;
Wellner, Alon;
Goldin-Azulay, Korina;
Chabriere, Eric;
Vorholt, Julia A.;
Erb, Tobias J.;
Tawfik, Dan S.

Publication type:

Article

Chaperonin overexpression promotes genetic variation and enzyme evolution.

Published in:

Nature, 2009, v. 459, n. 7247, p. 668, doi. 10.1038/nature08009

By:

Tokuriki, Nobuhiko;
Tawfik, Dan S.

Publication type:

Article

Bacilli glutamate dehydrogenases diverged via coevolution of transcription and enzyme regulation.

Published in:

EMBO Reports, 2017, v. 18, n. 7, p. 1139, doi. 10.15252/embr.201743990

By:

Noda‐Garcia, Lianet;
Romero Romero, Maria Luisa;
Longo, Liam M;
Kolodkin‐Gal, Ilana;
Tawfik, Dan S

Publication type:

Article

Spontaneous Emergence of S-Adenosylmethionine and the Evolution of Methylation.

Published in:

Angewandte Chemie International Edition, 2017, v. 56, n. 1, p. 343, doi. 10.1002/anie.201609615

By:

Laurino, Paola;
Tawfik, Dan S.

Publication type:

Article

Functional Proteins from Short Peptides: Dayhoff's Hypothesis Turns 50.

Published in:

Angewandte Chemie International Edition, 2016, v. 55, n. 52, p. 15966, doi. 10.1002/anie.201609977

By:

Romero Romero, M. Luisa;
Rabin, Avigayel;
Tawfik, Dan S.

Publication type:

Article

Evolution of new protein topologies through multistep gene rearrangements.

Published in:

Nature Genetics, 2006, v. 38, n. 2, p. 168, doi. 10.1038/ng1717

By:

Peisajovich, Sergio G.;
Rockah, Liat;
Tawfik, Dan S.

Publication type:

Article

The 'evolvability' of promiscuous protein functions.

Published in:

Nature Genetics, 2005, v. 37, n. 1, p. 73, doi. 10.1038/ng1482

By:

Aharoni, Amir;
Gaidukov, Leonid;
Khersonsky, Olga;
Gould, Stephen McQ;
Roodveldt, Cintia;
Tawfik, Dan S.

Publication type:

Article

Erratum to: Bridging themes: short protein segments found in different architectures.

Published in:

2021

By:

Kolodny, Rachel;
Nepomnyachiy, Sergey;
Tawfik, Dan S;
Ben-Tal, Nir

Publication type:

Correction Notice

Bridging Themes: Short Protein Segments Found in Different Architectures.

Published in:

Molecular Biology & Evolution, 2021, v. 38, n. 6, p. 2191, doi. 10.1093/molbev/msab017

By:

Kolodny, Rachel;
Nepomnyachiy, Sergey;
Tawfik, Dan S;
Ben-Tal, Nir

Publication type:

Article

Enzyme Evolution: An Epistatic Ratchet versus a Smooth Reversible Transition.

Published in:

Molecular Biology & Evolution, 2020, v. 37, n. 4, p. 1133, doi. 10.1093/molbev/msz298

By:

Ben-David, Moshe;
Soskine, Misha;
Dubovetskyi, Artem;
Cherukuri, Kesava-Phaneendra;
Dym, Orly;
Sussman, Joel L;
Liao, Qinghua;
Szeler, Klaudia;
Kamerlin, Shina Caroline Lynn;
Tawfik, Dan S

Publication type:

Article

On the Potential Origins of the High Stability of Reconstructed Ancestral Proteins.

Published in:

Molecular Biology & Evolution, 2016, v. 33, n. 10, p. 2633, doi. 10.1093/molbev/msw138

By:

Trudeau, Devin L.;
Kaltenbach, Miriam;
Tawfik, Dan S.

Publication type:

Article

Gal3 Binds Gal80 Tighter than Gal1 Indicating Adaptive Protein Changes Following Duplication.

Published in:

Molecular Biology & Evolution, 2016, v. 33, n. 2, p. 472, doi. 10.1093/molbev/msv240

By:

Lavy, Tali;
Yanagida, Hayato;
Tawfik, Dan S.

Publication type:

Article

Quinone Methide‐Based Organophosphate Hydrolases Inhibitors: Trans Proximity Labelers versus Cis Labeling Activity‐Based Probes.

Published in:

ChemBioChem, 2021, v. 22, n. 5, p. 894, doi. 10.1002/cbic.202000611

By:

Dubovetskyi, Artem;
Cherukuri, Kesava Phaneendra;
Ashani, Yacov;
Meshcheriakova, Anna;
Reuveny, Eitan;
Ben‐Nissan, Gili;
Sharon, Michal;
Fumagalli, Laura;
Tawfik, Dan S.

Publication type:

Article

From Phosphonates to Catalytic Antibodies. A Novel Route to Phosphonoester Transition State Analogs and Haptens.

Published in:

Phosphorus, Sulfur & Silicon & the Related Elements, 1993, v. 76, n. 1-4, p. 123, doi. 10.1080/10426509308032374

By:

Tawfik, Dan S.;
Eshhar, Zelig;
Green, Bernard S.

Publication type:

Article

Spontaneous Emergence of S-Adenosylmethionine and the Evolution of Methylation.

Published in:

Angewandte Chemie, 2017, v. 129, n. 1, p. 349, doi. 10.1002/ange.201609615

By:

Laurino, Paola;
Tawfik, Dan S.

Publication type:

Article

Funktionelle Proteine aus kurzen Peptiden: 50 Jahre nach Margaret Dayhoffs Hypothese.

Published in:

Angewandte Chemie, 2016, v. 128, n. 52, p. 16198, doi. 10.1002/ange.201609977

By:

Romero Romero, M. Luisa;
Rabin, Avigayel;
Tawfik, Dan S.

Publication type:

Article

Mutational effects and the evolution of new protein functions.

Published in:

2010

By:

Soskine, Misha;
Tawfik, Dan S.

Publication type:

journal article

Directed evolution of an extremely fast phosphotriesterase by in vitro compartmentalization.

Published in:

EMBO Journal, 2003, v. 22, n. 1, p. 24, doi. 10.1093/emboj/cdg014

By:

Griffiths, Andrew D.;
Tawfik, Dan S.

Publication type:

Article

Determining the interaction status and evolutionary fate of duplicated homomeric proteins.

Published in:

PLoS Computational Biology, 2020, v. 16, n. 8, p. 1, doi. 10.1371/journal.pcbi.1008145

By:

Mallik, Saurav;
Tawfik, Dan S.

Publication type:

Article

Protein Insertions and Deletions Enabled by Neutral Roaming in Sequence Space.

Published in:

Molecular Biology & Evolution, 2013, v. 30, n. 4, p. 761

By:

Tóth-Petróczy, Ágnes;
Tawfik, Dan S.

Publication type:

Article

Ohno's Model Revisited: Measuring the Frequency of Potentially Adaptive Mutations under Various Mutational Drifts.

Published in:

Molecular Biology & Evolution, 2008, v. 25, n. 11, p. 2311, doi. 10.1093/molbev/msn174

By:

Bershtein, Shimon;
Tawfik, Dan S.

Publication type:

Article

Mechanism of Hydrolysis and Aminolysis of Homocysteine Thiolactone.

Published in:

Chemistry - A European Journal, 2006, v. 12, n. 15, p. 4144, doi. 10.1002/chem.200501145

By:

Jonathan Garel;
Dan S. Tawfik

Publication type:

Article

Antibiotic resistance evolved via inactivation of a ribosomal RNA methylating enzyme.

Published in:

Nucleic Acids Research, 2016, v. 44, n. 18, p. 8897, doi. 10.1093/nar/gkw699

By:

Stojković, Vanja;
Noda-Garcia, Lianet;
Tawfik, Dan S.;
Fujimori, Danica Galonić

Publication type:

Article