Relationship between Antipsychotics and Weight in Patients with Prader-Willi Syndrome.

Elliott, Jennifer Padden; Cherpes, Gregory; Kamal, Khalid; Chopra, Ishveen; Harrison, Chelsea; Riedy, Mary; Herk, Brandon; McCrossin, Matt; Kalarchian, Melissa

Background Individuals with Prader-Willi Syndrome (PWS) are at increased risk for developing behavioral and psychiatric disorders, often requiring antipsychotics (APs). Contrary to significant AP-associated weight gain observed in the general population, existing literature suggests weight loss in patients with PWS. Study Objective To evaluate the relationship between AP use and body mass index (BMI) at admission, change in BMI during inpatient stay, and length of stay (LOS) in patients admitted to an inpatient PWS treatment program. Design Retrospective case-control study. Setting Hospital-based, inpatient PWS treatment program serving nationally and internationally referred children and adults with PWS. Patients Cases consisted of 52 pediatric patients with PWS who were taking APs at admission and during their stay, 97 adults with PWS who were taking APs at admission and during their stay, and 11 pediatric and adult patients with PWS who were AP naïve at admission and subsequently started an AP during their stay; all cases were matched with patients with PWS who were AP naïve at admission and during their stay by age (yrs), sex, and race-ethnicity (controls). Measurements and Main Results Between- and within-group differences in admission BMI, BMI change from admission to discharge, and LOS were analyzed. Admission BMI was lower (mean ± SD 36.8 ± 11.9 kg/m2 vs 46.7 ± 12.5 kg/m2, p2, p=0.027). No other comparisons between cases and controls were significantly different. Conclusion On average, patients with PWS who were prescribed APs lost weight during their inpatient stay, but this varied with patient age and duration of AP use.

PHYSIOLOGICAL effects of antipsychotic drugs; PRADER-Willi syndrome; OBESITY; WEIGHT gain; BODY weight

Pharmacotherapy, 2015, Vol 35, Issue 3, p260

0277-0008

Academic Journal

10.1002/phar.1558