A common calculation error of thermal processes in injection molding simulation programs is caused by the inadequate description of the heat transfer between the polymer melt and the wall of the mold. No correct description of the effect of pressure on the heat transfer coefficient is available for the numerical calculations of injection molding yet. During the injection molding cycle, the pressure of the melt can vary from atmospheric pressure to thousands of bars. When such a high pressure is applied, the heat transfer coefficient can change several orders of magnitude. To calculate heat removal accurately, we developed a novel measuring method and based on the measurement data, we created a model that describes the heat transfer coefficient as a function of pressure and temperature. Calculated maximal heat transfer coefficients vary between 250 and 800 W/(mK) at the pressure of 500 bar. The pressure dependence of the heat transfer coefficient can be described with a sigmoid function. The heat transfer coefficient increases as the temperature difference between mold and melt increases and as pressure increases. We determined measurement error and found it to be less than 5%.