Differential Impact of Weight Loss and Glycemic Control on Inflammasome Signaling.

Antonioli, Luca; Moriconi, Diego; Masi, Stefano; Bottazzo, Dario; Pellegrini, Carolina; Fornai, Matteo; Anselmino, Marco; Ferrannini, Ele; Blandizzi, Corrado; Taddei, Stefano; Nannipieri, Monica

Objective: Interleukin (IL)-1β is involved in obesity-associated inflammation and in the pathogenesis of type 2 diabetes (T2D) mellitus. Our aim was to correlate serum IL-1β and caspase-1 levels with weight loss, glucose metabolism, and insulin resistance (IR) after bariatric surgery.Methods: A total of 32 patients with morbid obesity and T2D (Ob-T2D) and 29 patients with morbid obesity and normal glucose tolerance (Ob-NGT), treated by Roux-en-Y gastric bypass, were studied before and 1 year after surgery. Sixteen healthy individuals served as a control (HC) group. IR was assessed by the oral glucose insulin sensitivity method. Plasma IL-1β levels and caspase-1 were measured.Results: Presurgery BMI was similar in Ob-NGT and Ob-T2D. IR was progressively impaired in Ob-NGT and Ob-T2D (P Conclusions: Plasma IL-1β and caspase-1 levels were inversely correlated with IR. Caspase-1 levels normalized after weight loss, whereas IL-1β normalized only in people without T2D, suggesting the persistence of a systemic inflammatory condition in people with T2D.

GASTRIC bypass; WEIGHT loss; GLYCEMIC control; MORBID obesity; TYPE 2 diabetes; PATHOLOGY; INFLAMMASOMES; PROTEINS; CELL differentiation; RESEARCH; HUMAN research subjects; RESEARCH methodology; INTERLEUKIN-1; BLOOD sugar; EVALUATION research; MEDICAL cooperation; CELLULAR signal transduction; COMPARATIVE studies; RESEARCH funding

Obesity (19307381), 2020, Vol 28, Issue 3, p609

1930-7381

Academic Journal

10.1002/oby.22734