Association of Maternal Obesity in Early Pregnancy with Adverse Pregnancy Outcomes: A Chinese Prospective Cohort Analysis.

Zhou, Yubo; Li, Hongtian; Zhang, Yali; Zhang, Le; Liu, Jufen; Liu, Jianmeng

<bold>Objective: </bold>This study aimed to examine the associations of maternal obesity in early pregnancy with adverse pregnancy outcomes.<bold>Methods: </bold>A prospective cohort analysis was performed among 18,481 Chinese nulliparous women, using data from a 2006 to 2009 trial of prenatal micronutrient supplementation. Obesity was defined as BMI ≥ 27.5 kg/m2 . Interested outcomes included fetal loss (spontaneous abortion plus stillbirth), infant death, total mortality, and preterm and birth weight outcomes.<bold>Results: </bold>Compared with normal weight, obesity was associated with total mortality (adjusted relative risks [ARR] 1.34; 95% CI: 1.03-1.74) and fetal loss (ARR 1.51; 95% CI: 1.15-1.99) but not with infant death (ARR 0.53; 95% CI: 0.20-1.46). Further analyses showed that obesity was particularly associated with spontaneous abortion (ARR 1.51; 95% CI: 1.13-2.02) rather than stillbirth (ARR 1.52; 95% CI: 0.65-3.57). Moreover, obesity was associated with preterm birth (ARR 1.59; 95% CI: 1.25-2.02), macrosomia (ARR 3.71, 95% CI: 3.01-4.59), and large for gestational age (ARR 2.93; 95% CI: 2.49-3.47).<bold>Conclusions: </bold>Maternal obesity in early pregnancy is associated with various adverse pregnancy outcomes in Chinese nulliparous women, suggesting the importance of an appropriate weight before and during pregnancy.

MISCARRIAGE; COHORT analysis; PREGNANCY; OBESITY; PREMATURE labor

Obesity (19307381), 2019, Vol 27, Issue 6, p1030

1930-7381

Academic Journal

10.1002/oby.22478