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- Title
Molecular precursors to produce para‐hydrogen enhanced metabolites at any field.
- Authors
Jagtap, Anil P.; Mamone, Salvatore; Glöggler, Stefan
- Abstract
Enhancing magnetic resonance signal via hyperpolarization techniques enables the real‐time detection of metabolic transformations even in vivo. The use of para‐hydrogen to enhance 13C‐enriched metabolites has opened a rapid pathway for the production of hyperpolarized metabolites, which usually requires specialized equipment. Metabolite precursors that can be hyperpolarized and converted into metabolites at any given field would open up opportunities for many labs to make use of this technology because already existing hardware could be used. We report here on the complete synthesis and hyperpolarization of suitable precursor molecules of the side‐arm hydrogenation approach. The better accessibility to such side‐arms promises that the para‐hydrogen approach can be implemented in every lab with existing two channel NMR spectrometers for 1H and 13C independent of the magnetic field.
- Subjects
METABOLITES; NMR spectrometers; MAGNETIC resonance; MAGNETIC fields; HYDROGENATION
- Publication
Magnetic Resonance in Chemistry, 2023, Vol 61, Issue 12, p674
- ISSN
0749-1581
- Publication type
Academic Journal
- DOI
10.1002/mrc.5402