Results
Title

Facile Synthesis of Multicompartment Micelles Based on Biocompatible Poly(3-hydroxyalkanoate).

Authors

Le Droumaguet, Benjamin; Babinot, Julien; Langlois, Valérie; Renard, Estelle; Guigner, Jean-Michel; Mura, Simona; Nicolas, Julien; Couvreur, Patrick

Abstract

In this paper, a straightforward method to produce poly(3-hydroxyalkanoate)-based multicompartment micelles (MCMs) is presented. Thiol-ene addition is used to graft sequentially perfluorooctyl chains and poly(ethylene glycol) oligomers onto poly(3-hydroxyoctanoate- co-hydroxyundecenoate) oligomers backbone. Well-defined copolymers are obtained as shown by 1H NMR and size-exclusion chromatography. After nanoprecipitation in water, novel PHA-based MCMs are evidenced by cryo-transmission electron microscopy. Moreover, the cytocompatibility of MCMs is demonstrated in vitro via cell viability assay.

Subjects

MICELLES; POLY-beta-hydroxyalkanoates; POLYETHYLENE glycol; OLIGOMERS; GEL permeation chromatography; NUCLEAR magnetic resonance

Publication

Macromolecular Rapid Communications, 2013, Vol 34, Issue 4, p362

ISSN

1022-1336

Publication type

Academic Journal

DOI

10.1002/marc.201200692