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- Title
Facile Synthesis of Multicompartment Micelles Based on Biocompatible Poly(3-hydroxyalkanoate).
- Authors
Le Droumaguet, Benjamin; Babinot, Julien; Langlois, Valérie; Renard, Estelle; Guigner, Jean-Michel; Mura, Simona; Nicolas, Julien; Couvreur, Patrick
- Abstract
In this paper, a straightforward method to produce poly(3-hydroxyalkanoate)-based multicompartment micelles (MCMs) is presented. Thiol-ene addition is used to graft sequentially perfluorooctyl chains and poly(ethylene glycol) oligomers onto poly(3-hydroxyoctanoate- co-hydroxyundecenoate) oligomers backbone. Well-defined copolymers are obtained as shown by 1H NMR and size-exclusion chromatography. After nanoprecipitation in water, novel PHA-based MCMs are evidenced by cryo-transmission electron microscopy. Moreover, the cytocompatibility of MCMs is demonstrated in vitro via cell viability assay.
- Subjects
MICELLES; POLY-beta-hydroxyalkanoates; POLYETHYLENE glycol; OLIGOMERS; GEL permeation chromatography; NUCLEAR magnetic resonance
- Publication
Macromolecular Rapid Communications, 2013, Vol 34, Issue 4, p362
- ISSN
1022-1336
- Publication type
Academic Journal
- DOI
10.1002/marc.201200692