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Title: Photo-Degradable, Protein-Polyelectrolyte Complex-Coated, Mesoporous Silica Nanoparticles for Controlled Co-Release of Protein and Model Drugs.
Authors: Hu, Jinming; Wan, Xuejuan; Liu, Tao; Liu, Shiyong
Abstract: The fabrication of photo-degradable, protein-polyelectrolyte complex (PPC)-coated, mesoporous silica nanoparticles (MSNs) and their controlled co-release of protein and model drugs is reported. Random copolymers composed of oligo(ethylene glycol) monomethyl ether methacrylate (OEGMA), and a photolabile o-nitrobenzyl-containing monomer, 5-(2′-(dimethylamino)ethoxy)-2-nitrobenzyl methacrylate (DENBMA), are first anchored onto the MSNs and then quaternary aminated, to obtain positively charged P(OEGMA- co-TENBMA) which exhibits photo-induced charge conversion characteristics. PPCs consisting of P(OEGMA- co-TENBMA) and the protein bovine serum albumin (BSA) are utilized as capping agents for the nanopores of the MSNs. Upon UV irradiation, charge conversion of P(OEGMA- co-TENBMA) can lead to the disruption of PPCs on MSNs and co-release of BSA and rhodamine B by electrostatic repulsion.
Subjects: DRUG delivery systems; MESOPOROUS silica; NANOPARTICLES; POLYELECTROLYTES; PROTEIN drugs; SERUM albumin
Publication: Macromolecular Rapid Communications, 2013, Vol 34, Issue 4, p341
ISSN: 1022-1336
Publication type: Academic Journal
DOI: 10.1002/marc.201200673

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Photo-Degradable, Protein-Polyelectrolyte Complex-Coated, Mesoporous Silica Nanoparticles for Controlled Co-Release of Protein and Model Drugs.