Results
Title

Native T<sub>1</sub> reference values for nonischemic cardiomyopathies and populations with increased cardiovascular risk: A systematic review and meta-analysis.

Authors

van den Boomen, Maaike; Slart, Riemer H. J. A.; Hulleman, Enzo V.; Dierckx, Rudi A. J. O.; Velthuis, Birgitta K.; van der Harst, Pim; Sosnovik, David E.; Borra, Ronald J. H.; Prakken, Niek H. J.

Abstract

Background: Although cardiac MR and T1 mapping are increasingly used to diagnose diffuse fibrosis based cardiac diseases, studies reporting T1 values in healthy and diseased myocardium, particular in nonischemic cardiomyopathies (NICM) and populations with increased cardiovascular risk, seem contradictory.Purpose: To determine the range of native myocardial T1 value ranges in patients with NICM and populations with increased cardiovascular risk.Study Type: Systemic review and meta-analysis.Population: Patients with NICM, including hypertrophic cardiomyopathy (HCM) and dilated cardiomyopathy (DCM), and patients with myocarditis (MC), iron overload, amyloidosis, Fabry disease, and populations with hypertension (HT), diabetes mellitus (DM), and obesity. FIELD STRENGTH/SEQUENCE: (Shortened) modified Look-Locker inversion-recovery MR sequence at 1.5 or 3T.Assessment: PubMed and Embase were searched following the PRISMA guidelines.Statistical Tests: The summary of standard mean difference (SMD) between the diseased and a healthy control populations was generated using a random-effects model in combination with meta-regression analysis.Results: The SMD for HCM, DCM, and MC patients were significantly increased (1.41, 1.48, and 1.96, respectively, P Data Conclusions: Native T1 mapping by using an (Sh)MOLLI sequence can potentially assess myocardial changes in HCM, DCM, MC, iron overload, amyloidosis, and Fabry disease compared to controls. In addition, it can help to diagnose left-ventricular remodeling in HT patients.Level Of Evidence: 2 Technical Efficacy: Stage 3 J. Magn. Reson. Imaging 2018;47:891-912.

Publication

Journal of Magnetic Resonance Imaging, 2018, Vol 47, Issue 4, p891

ISSN

1053-1807

Publication type

Academic Journal

DOI

10.1002/jmri.25885