Title: Synthesis of stable isotope–labeled chloroquine and amodiaquine and their metabolites.
Authors: Wu, Ruilian; Williams, Robert F.; Silks, L.A. "Pete"; Schmidt, Jurgen G.
Abstract: Anti‐malaria drugs chloroquine and amodiaquine and their metabolites were synthesized to incorporate 13C and 15N starting from U‐13C–labeled benzene to give M 7 isotopomers. Chloroquine and its metabolites were prepared from 7‐chloro‐1,2,3,4‐tetrahydroquinolin‐4‐one through an aryl substitution with the corresponding amines; and the amodiaquine and its metabolites were prepared from 4,7‐dichloroquinoline in a similar fashion.
Subjects: CHLOROQUINE; ISOMERISM; METABOLITES; AMINES; BENZENE
Publication: Journal of Labelled Compounds & Radiopharmaceuticals, 2019, Vol 62, Issue 5, p230
ISSN: 0362-4803
Publication type: Academic Journal
DOI: 10.1002/jlcr.3721

Synthesis of stable isotope–labeled chloroquine and amodiaquine and their metabolites.

Wu, Ruilian; Williams, Robert F.; Silks, L.A. "Pete"; Schmidt, Jurgen G.