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- Title
Synthesis of stable isotope–labeled chloroquine and amodiaquine and their metabolites.
- Authors
Wu, Ruilian; Williams, Robert F.; Silks, L.A. "Pete"; Schmidt, Jurgen G.
- Abstract
Anti‐malaria drugs chloroquine and amodiaquine and their metabolites were synthesized to incorporate 13C and 15N starting from U‐13C–labeled benzene to give M 7 isotopomers. Chloroquine and its metabolites were prepared from 7‐chloro‐1,2,3,4‐tetrahydroquinolin‐4‐one through an aryl substitution with the corresponding amines; and the amodiaquine and its metabolites were prepared from 4,7‐dichloroquinoline in a similar fashion.
- Subjects
CHLOROQUINE; ISOMERISM; METABOLITES; AMINES; BENZENE
- Publication
Journal of Labelled Compounds & Radiopharmaceuticals, 2019, Vol 62, Issue 5, p230
- ISSN
0362-4803
- Publication type
Academic Journal
- DOI
10.1002/jlcr.3721