<italic>α</italic>_{<italic>v</italic>}<italic>β</italic>_{<italic>3</italic>} mediated tumor imaging using ^99mTc labeled NAD/monosaccharide coated ferrihydrite nanoparticles.

Kim, Eun‐Mi; Oh, Phil‐Sun; Jeong, Hwan‐Jeong; Lim, Seok Tae; Sohn, Myung‐Hee

This study describes the synthesis of highly water‐soluble, non‐toxic, and biocompatible nicotinamide adenine dinucleotide (NAD)/glucosamine (=Nga1Fh) and NAD/glucosamine/gluconic acid coated ferrihydrite nanoparticles (=Nga2Fh) and their possible uses to target tumors in living animals via 99mTc and 125I radioisotope labeling. The structural properties were investigated using DLS, zeta potential, TEM, FT‐IR, XRD, and Raman spectroscopy. The cell toxicity in CT26 cancer cells and in vivo tumor targetability in U87MG and CT26 tumor‐bearing mice was further evaluated using cRGDyK‐tagged and cRGDfK‐tagged ferrihydrite nanoparticles. The average diameters of the resulting Nga1Fh and Nga2Fh nanoparticles were 99mTc‐cRGDfK‐Nga2Fh showed the highest tumor uptake in a U87MG tumor‐bearing mouse when compared with that of 99mTc‐cRGDyK‐Nga2Fh and 99mTc‐Nga2Fh. The image‐based tumor‐to‐muscle ratio by time for 99mTc‐cRGDfK‐Nga2Fh was 3.8 ± 1.7, 4.2 ± 2.0, 7 ± 1.5, 13 ± 2.0, 8 ± 3.7, and 2 ± 1.6 at 5 and 30 minutes, 1, 2, 4, and 24 hours, respectively. Although further studies are needed, the NAD/monosaccharide coated ferrihydrite nanoparticles could be presented as an interesting material for a drug delivery system.

MONOSACCHARIDES; NANOPARTICLES; NICOTINAMIDE nucleotides; NAD (Coenzyme); INTEGRINS

Journal of Labelled Compounds & Radiopharmaceuticals, 2018, Vol 61, Issue 1, p18

0362-4803

Academic Journal

10.1002/jlcr.3565