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- Title
Synthesis of the olanzapine labeled by carbon-14.
- Authors
Saadatjoo, Naghi; Javaheri, Mohsen; Saemian, Nader; Amini, Mohsen
- Abstract
Olanzapine is one of the most widely used antipsychotic drugs, which acts as an antagonist for multiple neurotransmitter receptor sites. 2-Methyl-4-(4-methyl-1-piperazinyl)-10H-thieno [2,3-b][1,5] benzodiazepine (Olanzapine) labeled with carbon-14 in the four positions has been synthesized as part of a three-step sequence from 2-amino-5-methylthiophene-3-carbonitrile-[carbonitrile-14C].
- Subjects
PIRENZEPINE; ANTIULCER drugs; OLANZAPINE; NEUROTRANSMITTERS; NEUROCHEMISTRY
- Publication
Journal of Labelled Compounds & Radiopharmaceuticals, 2016, Vol 59, Issue 8, p325
- ISSN
0362-4803
- Publication type
Academic Journal
- DOI
10.1002/jlcr.3407