Title: Synthesis of the olanzapine labeled by carbon-14.
Authors: Saadatjoo, Naghi; Javaheri, Mohsen; Saemian, Nader; Amini, Mohsen
Abstract: Olanzapine is one of the most widely used antipsychotic drugs, which acts as an antagonist for multiple neurotransmitter receptor sites. 2-Methyl-4-(4-methyl-1-piperazinyl)-10H-thieno [2,3-b][1,5] benzodiazepine (Olanzapine) labeled with carbon-14 in the four positions has been synthesized as part of a three-step sequence from 2-amino-5-methylthiophene-3-carbonitrile-[carbonitrile-14C].
Subjects: PIRENZEPINE; ANTIULCER drugs; OLANZAPINE; NEUROTRANSMITTERS; NEUROCHEMISTRY
Publication: Journal of Labelled Compounds & Radiopharmaceuticals, 2016, Vol 59, Issue 8, p325
ISSN: 0362-4803
Publication type: Academic Journal
DOI: 10.1002/jlcr.3407

Synthesis of the olanzapine labeled by carbon-14.

Saadatjoo, Naghi; Javaheri, Mohsen; Saemian, Nader; Amini, Mohsen