- Title
Synthesis of a doxycycline-[<sup>13</sup>CD<sub>3</sub>] standard.
- Authors
Bupp, James E.; Tanga, Mary J.
- Abstract
A stable isotope labelled mass spectrometry internal standard of the antibiotic doxycycline was prepared to assist in pharmacokinetic analyses. Our approach was to first N-demethylate doxycycline using a non-classical Polonovski reaction and then re-methylate using methyl-[13CD3] iodide, which gave doxycycline-[13CD3] with an isotopic purity of 99%.
- Subjects
DOXYCYCLINE; ANTIBIOTICS; PHARMACOKINETICS; MASS spectrometry; ANTIBACTERIAL agents
- Publication
Journal of Labelled Compounds & Radiopharmaceuticals, 2016, Vol 59, Issue 7, p291
- ISSN
0362-4803
- Publication type
Academic Journal
- DOI
10.1002/jlcr.3397