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Title

Synthesis of a doxycycline-[<sup>13</sup>CD<sub>3</sub>] standard.

Authors

Bupp, James E.; Tanga, Mary J.

Abstract

A stable isotope labelled mass spectrometry internal standard of the antibiotic doxycycline was prepared to assist in pharmacokinetic analyses. Our approach was to first N-demethylate doxycycline using a non-classical Polonovski reaction and then re-methylate using methyl-[13CD3] iodide, which gave doxycycline-[13CD3] with an isotopic purity of 99%.

Subjects

DOXYCYCLINE; ANTIBIOTICS; PHARMACOKINETICS; MASS spectrometry; ANTIBACTERIAL agents

Publication

Journal of Labelled Compounds & Radiopharmaceuticals, 2016, Vol 59, Issue 7, p291

ISSN

0362-4803

Publication type

Academic Journal

DOI

10.1002/jlcr.3397