Title: Carbon-14 labeling of K777•HCl, a therapeutic agent for Chagas disease.
Authors: Rhee, Sung Whi; Bradford, Wallace W.; Malerich, Jeremiah P.; Tanga, Mary J.
Abstract: The antitrypanosomal agent K777•HCl was labeled with carbon-14 to support absorption, distribution, metabolism, and excretion studies of this potential new drug for the treatment of Chagas disease. The radiolabeled compound was prepared in eight steps from [14C(U)]-( l)-phenylalanine with a specific activity of 54.4 mCi/mmol and an overall radiochemical yield of 4.1%.
Subjects: CARBON isotopes; CHAGAS' disease treatment; TRYPANOSOMA cruzi; CONENOSES; RADIOCHEMICAL yield
Publication: Journal of Labelled Compounds & Radiopharmaceuticals, 2013, Vol 56, Issue 9/10, p461
ISSN: 0362-4803
Publication type: Academic Journal
DOI: 10.1002/jlcr.3107

Carbon-14 labeling of K777•HCl, a therapeutic agent for Chagas disease.

Rhee, Sung Whi; Bradford, Wallace W.; Malerich, Jeremiah P.; Tanga, Mary J.