Title: Synthesis, Characterization, and Biological Evaluation of 10H-Phenothiazines, Their Sulfones and Ribofuranosides.
Authors: Gautam, Naveen; Gupta, Shikha; Ajmera, Neha; Gautam, D. C.
Abstract: 10H-phenothiazines are synthesized via Smiles rearrangement. These prepared phenothiazines act as a base to prepare ribofuranosides by treating them with b- D-ribofuranosyl-1-acetate-2,3,5-tribenzoate. 10H-phenothiazines on refluxing with hydrogen peroxide in glacial acetic acid gave 10H-phenothiazine-5,5-dioxides. The synthesized compounds were evaluated for their antioxidative properties through in vitro studies, and they are also screened for their antimicrobial activity. The structure of the synthesized compounds has been established by elemental analysis and spectroscopic data.
Subjects: ORGANIC synthesis; PHENOTHIAZINE; SULFONES; FURANOSIDES; ACETIC acid; ANTI-infective agents; HYDROGEN peroxide; SPECTRUM analysis
Publication: Journal of Heterocyclic Chemistry, 2012, Vol 49, Issue 3, p710
ISSN: 0022-152X
Publication type: Academic Journal
DOI: 10.1002/jhet.771

Synthesis, Characterization, and Biological Evaluation of 10H-Phenothiazines, Their Sulfones and Ribofuranosides.

Gautam, Naveen; Gupta, Shikha; Ajmera, Neha; Gautam, D. C.