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- Title
Tandem synthesis of 2,3-dihydroquinazolin-4(1 H)-ones on grinding under solvent-free conditions.
- Authors
Ding, Quan-Sheng; Zhang, Ji-Lei; Chen, Jiu-Xi; Liu, Miao-Chang; Ding, Jin-Chang; Wu, Hua-Yue
- Abstract
Citric acid promoted synthesis of a mini-library 2,3-dihydroquinazolin-4(1 H)-ones with good to excellent yields is achieved by tandem reaction of anthranilamides (or anthranilhydrazides) with aldehydes on grinding at room temperature under solvent-free conditions. This method has notable advantages in terms of simple workup, short reaction time, cost-effective, and environmentally benign. J. Heterocyclic Chem., (2012).
- Subjects
ALDEHYDES; HETEROCYCLIC compounds; NUCLEAR magnetic resonance spectroscopy; ETHYL acetate; OXO compounds
- Publication
Journal of Heterocyclic Chemistry, 2012, Vol 49, Issue 2, p375
- ISSN
0022-152X
- Publication type
Academic Journal
- DOI
10.1002/jhet.759