Results
Title

Tandem synthesis of 2,3-dihydroquinazolin-4(1 H)-ones on grinding under solvent-free conditions.

Authors

Ding, Quan-Sheng; Zhang, Ji-Lei; Chen, Jiu-Xi; Liu, Miao-Chang; Ding, Jin-Chang; Wu, Hua-Yue

Abstract

Citric acid promoted synthesis of a mini-library 2,3-dihydroquinazolin-4(1 H)-ones with good to excellent yields is achieved by tandem reaction of anthranilamides (or anthranilhydrazides) with aldehydes on grinding at room temperature under solvent-free conditions. This method has notable advantages in terms of simple workup, short reaction time, cost-effective, and environmentally benign. J. Heterocyclic Chem., (2012).

Subjects

ALDEHYDES; HETEROCYCLIC compounds; NUCLEAR magnetic resonance spectroscopy; ETHYL acetate; OXO compounds

Publication

Journal of Heterocyclic Chemistry, 2012, Vol 49, Issue 2, p375

ISSN

0022-152X

Publication type

Academic Journal

DOI

10.1002/jhet.759