Catalyst-Free Protocol for the Synthesis of Quinoxalines and Pyrazines in PEG.

Huang, Tie ‐ Qiang; Qu, Wen ‐ Yan; Ding, Jin ‐ Chang; Liu, Miao ‐ Chang; Wu, Hua ‐ Yue; Chen, Jiu ‐ Xi

A facile and simple catalyst-free protocol has been developed for the condensation of 1,2-diketones with aromatic 1,2-diamines in polyethylene glycol (PEG), providing quinoxaline derivatives in good yields. The important features of the methodology are broad substrates scope, simple workup, catalyst free, environmentally benign, and no requirement for metal catalysts. It is noteworthy that the cyclization reaction of 1,2-diketones with aliphatic 1,2-diamines is also conducted smoothly to afford pyrazines in good yields under the standard conditions. In addition, PEG could be recovered easily and was reused without evident loss in activity

CATALYST synthesis; QUINOXALINES; PYRAZINES; CHEMICAL derivatives; POLYETHYLENE glycol; METAL catalysts; RING formation (Chemistry)

Journal of Heterocyclic Chemistry, 2013, Vol 50, Issue 2, p293

0022-152X

Academic Journal

10.1002/jhet.1043