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Impact of obesity and roux‐en‐Y gastric bypass on the pharmacokinetics of (R)‐ and (S)‐omeprazole and intragastric pH.
Published in:
CPT: Pharmacometrics & Systems Pharmacology, 2024, v. 13, n. 9, p. 1528, doi. 10.1002/psp4.13189
By:
- Pippa, Leandro F.;
- Vozmediano, Valvanera;
- Mitrov‐Winkelmolen, Lieke;
- Touw, Daan;
- Soliman, Amira;
- Cristofoletti, Rodrigo;
- Salgado Junior, Wilson;
- de Moraes, Natalia Valadares
Publication type:
Article
Interspecies Brain PBPK Modeling Platform to Predict Passive Transport through the Blood–Brain Barrier and Assess Target Site Disposition.
Published in:
Pharmaceutics, 2024, v. 16, n. 2, p. 226, doi. 10.3390/pharmaceutics16020226
By:
- Mehta, Parsshava;
- Soliman, Amira;
- Rodriguez-Vera, Leyanis;
- Schmidt, Stephan;
- Muniz, Paula;
- Rodriguez, Monica;
- Forcadell, Marta;
- Gonzalez-Perez, Emili;
- Vozmediano, Valvanera
Publication type:
Article
Model-Based Analysis of In Vivo Release Data of Levonorgestrel Implants: Projecting Long-Term Systemic Exposure.
Published in:
Pharmaceutics, 2023, v. 15, n. 5, p. 1393, doi. 10.3390/pharmaceutics15051393
By:
- Kim, Soyoung;
- Cicali, Brian;
- Pressly, Michelle;
- Da Silva, Lais;
- Wendl, Thomas;
- Vozmediano, Valvanera;
- Schmidt, Stephan;
- Cristofoletti, Rodrigo
Publication type:
Article
Leveraging Physiologically Based Modelling to Provide Insights on the Absorption of Paliperidone Extended-Release Formulation under Fed and Fasting Conditions.
Published in:
Pharmaceutics, 2023, v. 15, n. 2, p. 629, doi. 10.3390/pharmaceutics15020629
By:
- Subhani, Saima;
- Lukacova, Viera;
- Kim, Chaejin;
- Rodriguez-Vera, Leyanis;
- Muniz, Paula;
- Rodriguez, Monica;
- Cristofoletti, Rodrigo;
- Van Os, Sandra;
- Suarez, Elena;
- Schmidt, Stephan;
- Vozmediano, Valvanera
Publication type:
Article
In Vitro Pharmacokinetic/Pharmacodynamic Modelling and Simulation of Amphotericin B against Candida auris.
Published in:
Pharmaceutics, 2021, v. 13, n. 11, p. 1767, doi. 10.3390/pharmaceutics13111767
By:
- Caballero, Unai;
- Eraso, Elena;
- Pemán, Javier;
- Quindós, Guillermo;
- Vozmediano, Valvanera;
- Schmidt, Stephan;
- Jauregizar, Nerea
Publication type:
Article
Model-Informed Optimization of a Pediatric Clinical Pharmacokinetic Trial of a New Spironolactone Liquid Formulation.
Published in:
Pharmaceutics, 2021, v. 13, n. 6, p. 849, doi. 10.3390/pharmaceutics13060849
By:
- Tatipalli, Manasa;
- Siripuram, Vijay Kumar;
- Long, Tao;
- Shuster, Diana;
- Bernstein, Galina;
- Martineau, Pierre;
- Cook, Kim A.;
- Cristofoletti, Rodrigo;
- Schmidt, Stephan;
- Vozmediano, Valvanera
Publication type:
Article
Key Factors in Effective Patient-Tailored Dosing of Fluoroquinolones in Urological Infections: Interindividual Pharmacokinetic and Pharmacodynamic Variability.
Published in:
Antibiotics (2079-6382), 2022, v. 11, n. 5, p. 641, doi. 10.3390/antibiotics11050641
By:
- Estradé, Oskar;
- Vozmediano, Valvanera;
- Carral, Nerea;
- Isla, Arantxa;
- González, Margarita;
- Poole, Rachel;
- Suarez, Elena
Publication type:
Article
In Vitro Synergistic Interactions of Isavuconazole and Echinocandins against Candida auris.
Published in:
Antibiotics (2079-6382), 2021, v. 10, n. 4, p. 355, doi. 10.3390/antibiotics10040355
By:
- Caballero, Unai;
- Kim, Sarah;
- Eraso, Elena;
- Quindós, Guillermo;
- Vozmediano, Valvanera;
- Schmidt, Stephan;
- Jauregizar, Nerea
Publication type:
Article
Pharmacokinetics and safety of bilastine in children aged 6 to 11 years with allergic rhinoconjunctivitis or chronic urticaria.
Published in:
2020
By:
- Rodríguez, Mónica;
- Vozmediano, Valvanera;
- García-Bea, Aintzane;
- Novák, Zoltán;
- Yáñez, Anahí;
- Campo, Cristina;
- Labeaga, Luis
Publication type:
journal article
Model Informed Pediatric Development Applied to Bilastine: Ontogenic PK Model Development, Dose Selection for First Time in Children and PK Study Design.
Published in:
Pharmaceutical Research, 2017, v. 34, n. 12, p. 2720, doi. 10.1007/s11095-017-2248-6
By:
- Vozmediano, Valvanera;
- Sologuren, Ander;
- Lukas, John;
- Leal, Nerea;
- Rodriguez, Mónica
Publication type:
Article
Evaluation of Fentanyl Disposition and Effects in Newborn Piglets as an Experimental Model for Human Neonates.
Published in:
PLoS ONE, 2014, v. 9, n. 3, p. 1, doi. 10.1371/journal.pone.0090728
By:
- Rey-Santano, Carmen;
- Mielgo, Victoria;
- Valls-i-Soler, Adolfo;
- Encinas, Esther;
- Lukas, John C.;
- Vozmediano, Valvanera;
- Suárez, Elena
Publication type:
Article
Physiologically Based Pharmacokinetic Modeling of Monoclonal Antibodies in Pediatric Populations Using PK-Sim.
Published in:
Frontiers in Pharmacology, 2020, v. 11, p. 1, doi. 10.3389/fphar.2020.00868
By:
- Basu, Sumit;
- Lien, Yi Ting (Kayla);
- Vozmediano, Valvanera;
- Schlender, Jan-Frederik;
- Eissing, Thomas;
- Schmidt, Stephan;
- Niederalt, Christoph
Publication type:
Article
Rerouting cardiovascular management following gastric bypass surgery: Dose optimization of carvedilol using population‐based analysis.
Published in:
British Journal of Clinical Pharmacology, 2024, v. 90, n. 9, p. 2223, doi. 10.1111/bcp.16129
By:
- Yamamoto, Priscila Akemi;
- Vozmediano, Valvanera;
- Cristofoletti, Rodrigo;
- Jiang, Jinmai;
- Schmittgen, Thomas D.;
- de Gaitani, Cristiane Masetto;
- Kemp, Rafael;
- Sankarankutty, Ajith Kumar;
- dos Santos, Jose Sebastião;
- Salgado Junior, Wilson;
- de Moraes, Natalia Valadares
Publication type:
Article
Vancomycin in peritoneal dialysis: Clinical pharmacology considerations in therapy.
Published in:
Peritoneal Dialysis International, 2020, v. 40, n. 4, p. 384, doi. 10.1177/0896860819889774
By:
- Lam, Edwin;
- Yi Ting (Kayla) Lien;
- Kraft, Water K.;
- Piraino, Beth;
- Vozmediano, Valvanera;
- Schmidt, Stephan;
- Jingjing Zhang
Publication type:
Article
Development of a Translational Exposure‐Bracketing Approach to Streamline the Development of Hormonal Contraceptive Drug Products.
Published in:
Clinical Pharmacology & Therapeutics, 2022, v. 112, n. 4, p. 909, doi. 10.1002/cpt.2690
By:
- Cicali, Brian;
- Da Silva, Lais;
- Sarayani, Amir;
- Lingineni, Karthik;
- Pressly, Michelle;
- Kim, Soyoung;
- Wendl, Thomas;
- Hoechel, Joachim;
- Vozmediano, Valvanera;
- Winterstein, Almut G.;
- Brown, Joshua D.;
- Schmidt, Stephan;
- Cristofoletti, Rodrigo
Publication type:
Article
Determining the Exposure Threshold for Levonorgestrel Efficacy Using an Integrated Model Based Meta‐Analysis Approach.
Published in:
Clinical Pharmacology & Therapeutics, 2022, v. 111, n. 2, p. 509, doi. 10.1002/cpt.2457
By:
- Lingineni, Karthik;
- Chaturvedula, Ayyappa;
- Cicali, Brian;
- Cristofoletti, Rodrigo;
- Wendl, Thomas;
- Hoechel, Joachim;
- Brown, Joshua D.;
- Vozmediano, Valvanera;
- Schmidt, Stephan
Publication type:
Article
Requirements, expectations, challenges and opportunities associated with training the next generation of pharmacometricians.
Published in:
CPT: Pharmacometrics & Systems Pharmacology, 2023, v. 12, n. 7, p. 883, doi. 10.1002/psp4.12970
By:
- Schmidt, Stephan;
- Vozmediano, Valvanera;
- Cristofoletti, Rodrigo;
- Kim, Sarah;
- Lin, Zhoumeng;
- de Moraes, Natalia;
- Azeredo, Francine;
- Cicali, Brian;
- Leuenberger, Hans;
- Brown, Joshua D.;
- Jin, Jin Y.;
- Musante, Cynthia J.;
- Tannenbaum, Stacey;
- Wang, Yaning
Publication type:
Article
PK/PD modeling and simulation of the in vitro activity of the combinations of isavuconazole with echinocandins against Candida auris.
Published in:
CPT: Pharmacometrics & Systems Pharmacology, 2023, v. 12, n. 6, p. 770, doi. 10.1002/psp4.12949
By:
- Caballero, Unai;
- Eraso, Elena;
- Quindós, Guillermo;
- Vozmediano, Valvanera;
- Schmidt, Stephan;
- Jauregizar, Nerea
Publication type:
Article
Application of a dual mechanistic approach to support bilastine dose selection for older adults.
Published in:
CPT: Pharmacometrics & Systems Pharmacology, 2021, v. 10, n. 9, p. 1006, doi. 10.1002/psp4.12671
By:
- Kim, Chaejin;
- Lo Re, Valentina;
- Rodriguez, Monica;
- Lukas, John C.;
- Leal, Nerea;
- Campo, Cristina;
- García‐Bea, Aintzane;
- Suarez, Elena;
- Schmidt, Stephan;
- Vozmediano, Valvanera
Publication type:
Article
Quantitative Assessment of Levonorgestrel Binding Partner Interplay and Drug‐Drug Interactions Using Physiologically Based Pharmacokinetic Modeling.
Published in:
CPT: Pharmacometrics & Systems Pharmacology, 2021, v. 10, n. 1, p. 48, doi. 10.1002/psp4.12572
By:
- Cicali, Brian;
- Lingineni, Karthik;
- Cristofoletti, Rodrigo;
- Wendl, Thomas;
- Hoechel, Joachim;
- Wiesinger, Herbert;
- Chaturvedula, Ayyappa;
- Vozmediano, Valvanera;
- Schmidt, Stephan
Publication type:
Article
Pharmacometrics, Physiologically Based Pharmacokinetics, Quantitative Systems Pharmacology--What's Next?--Joining Mechanistic and Epidemiological Approaches.
Published in:
CPT: Pharmacometrics & Systems Pharmacology, 2019, v. 8, n. 6, p. 352, doi. 10.1002/psp4.12425
By:
- Schmidt, Stephan;
- Kim, Sarah;
- Vozmediano, Valvanera;
- Cristofoletti, Rodrigo;
- Winterstein, Almut G.;
- Brown, Joshua D.
Publication type:
Article
Establishing a Multidisciplinary Framework to Study Drug‐Drug Interactions of Hormonal Contraceptives: An Invitation to Collaborate.
Published in:
CPT: Pharmacometrics & Systems Pharmacology, 2018, v. 7, n. 11, p. 706, doi. 10.1002/psp4.12357
By:
- Lesko, Lawrence J.;
- Vozmediano, Valvanera;
- Brown, Joshua D.;
- Winterstein, Almut;
- Zhao, Ping;
- Lippert, Jörg;
- Höchel, Joachim;
- Chaturvedula, Ayyappa;
- White, Annesha;
- Schmidt, Stephan
Publication type:
Article
Incorporating Pharmacometrics into Pharmacoeconomic Models: Applications from Drug Development.
Published in:
PharmacoEconomics, 2020, v. 38, n. 10, p. 1031, doi. 10.1007/s40273-020-00944-0
By:
- Srinivasan, Meenakshi;
- White, Annesha;
- Chaturvedula, Ayyappa;
- Vozmediano, Valvanera;
- Schmidt, Stephan;
- Plouffe, Leo;
- Wingate, La'Marcus T.
Publication type:
Article
Pharmacokinetic and Pharmacodynamic Analysis of Acetaminophen and Ibuprofen Dual Therapy for Patent Ductus Arteriosus Closure in Preterm Neonates at Less Than 29 Weeks of Gestation.
Published in:
Journal of Clinical Pharmacology, 2024, v. 64, n. 3, p. 312, doi. 10.1002/jcph.2386
By:
- Almoslem, Mohammed;
- Shah, Sanket D.;
- Vozmediano, Valvanera;
- Guzy, Serge;
- Kim, Sarah;
- Hudak, Mark L.;
- Schmidt, Stephan
Publication type:
Article
Effect of Roux‐En‐Y Gastric Bypass in the Pharmacokinetics of (R)‐Carvedilol and (S)‐Carvedilol.
Published in:
Journal of Clinical Pharmacology, 2023, v. 63, n. 7, p. 838, doi. 10.1002/jcph.2221
By:
- Yamamoto, Priscila Akemi;
- Cristofoletti, Rodrigo;
- Vozmediano, Valvanera;
- de Gaitani, Cristiane Masetto;
- da Silva, Rodrigo Moreira;
- Kemp, Rafael;
- Sankarankutty, Ajith Kumar;
- Salgado Junior, Wilson;
- Santos, Jose Sebastião dos;
- de Moraes, Natalia Valadares
Publication type:
Article
Population Pharmacokinetic Modeling of Acetaminophen Protein Adducts in Adults and Children.
Published in:
Journal of Clinical Pharmacology, 2020, v. 60, n. 5, p. 595, doi. 10.1002/jcph.1555
By:
- Sibo Jiang;
- Madrasi, Kumpal;
- Samant, Tanay;
- Lagishetty, Chakradhar;
- Vozmediano, Valvanera;
- Chiew, Angela;
- Abdel-Rahman, Susan M.;
- James, Laura P.;
- Schmidt, Stephan
Publication type:
Article
Real‐World Data Approaches for Early Detection of Potential Safety and Effectiveness Signals for Generic Substitution: A Metoprolol Extended‐Release Case Study.
Published in:
Journal of Clinical Pharmacology, 2019, v. 59, n. 9, p. 1275, doi. 10.1002/jcph.1436
By:
- Brown, Joshua D.;
- Henriksen, Carl;
- Vozmediano, Valvanera;
- Schmidt, Stephan
Publication type:
Article
Acetaminophen Protein Adducts in Hospitalized Children Receiving Multiple Doses of Acetaminophen.
Published in:
Journal of Clinical Pharmacology, 2019, v. 59, n. 10, p. 1291, doi. 10.1002/jcph.1442
By:
- Jiang, Sibo;
- Vozmediano, Valvanera;
- Abdel‐Rahman, Susan M.;
- Schmidt, Stephan;
- James, Laura P.
Publication type:
Article
Evaluating the Clinical Impact of Formulation Variability: A Metoprolol Extended‐Release Case Study.
Published in:
Journal of Clinical Pharmacology, 2019, v. 59, n. 9, p. 1266, doi. 10.1002/jcph.1433
By:
- Kim, Sarah;
- Sharma, Vishnu D.;
- Lingineni, Karthik;
- Farhan, Nashid;
- Fang, Lanyan;
- Zhao, Liang;
- Brown, Joshua D.;
- Cristofoletti, Rodrigo;
- Vozmediano, Valvanera;
- Ait‐Oudhia, Sihem;
- Lesko, Lawrence J.;
- Trame, Mirjam N.;
- Schmidt, Stephan
Publication type:
Article
A randomized, cross‐over trial of metoprolol succinate formulations to evaluate PK and PD end points for therapeutic equivalence.
Published in:
CTS: Clinical & Translational Science, 2022, v. 15, n. 7, p. 1764, doi. 10.1111/cts.13294
By:
- Mosley, Scott A.;
- Kim, Sarah;
- El Rouby, Nihal;
- Lingineni, Karthik;
- Esteban, Valvanera Vozmediano;
- Gong, Yan;
- Chen, Yiqing;
- Estores, David;
- Feng, Kairui;
- Kim, Hyewon;
- Kinjo, Minori;
- Langaee, Taimour;
- Li, Zhichuan;
- Schmidt, Siegfried O. F.;
- Johnson, Julie A.;
- Frye, Reginald F.;
- Fang, Lanyan;
- Zhao, Liang;
- Binkley, Philip F.;
- Schmidt, Stephan
Publication type:
Article
A Predictive Pharmacokinetic/Pharmacodynamic Model of Fentanyl for Analgesia/Sedation in Neonates Based on a Semi-Physiologic Approach.
Published in:
Pediatric Drugs, 2013, v. 15, n. 3, p. 247, doi. 10.1007/s40272-013-0029-1
By:
- Encinas, Esther;
- Calvo, Rosario;
- Lukas, John;
- Vozmediano, Valvanera;
- Rodriguez, Monica;
- Suarez, Elena
Publication type:
Article

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