Works matching DE "DNA damage"

Results: 5000

PARP Inhibitors in Ovarian Cancer: Resistance Mechanisms, Clinical Evidence, and Evolving Strategies.

Published in:

Biomedicines, 2025, v. 13, n. 5, p. 1126, doi. 10.3390/biomedicines13051126

By:

Apelian, Shant;
Martincuks, Antons;
Whittum, Michelle;
Yasukawa, Maya;
Nguy, Lindsey;
Mathyk, Begum;
Andikyan, Vaagn;
Anderson, Matthew L.;
Rutherford, Thomas;
Cristea, Mihaela;
Stewart, Daphne;
Kohut, Adrian

Publication type:

Article

Investigation of the Effect of Amniomax on Lidocaine-Induced Toxicity in Healthy Colon Cell Culture.

Published in:

Biomedicines, 2025, v. 13, n. 5, p. 1074, doi. 10.3390/biomedicines13051074

By:

Karakuş, Seçil Azime;
Saraçoğlu, Ayten;
Güler, Eray Metin;
Bozali, Kübra;
Önal, Ceren;
Bulun, Yekbun;
Gaszyński, Tomasz;
Ratajczyk, Paweł;
Saraçoğlu, Kemal Tolga

Publication type:

Article

Cancer Vulnerabilities Through Targeting the ATR/Chk1 and ATM/Chk2 Axes in the Context of DNA Damage.

Published in:

Cells (2073-4409), 2025, v. 14, n. 10, p. 748, doi. 10.3390/cells14100748

By:

Fernandez, Anell;
Artola, Maider;
Leon, Sergio;
Otegui, Nerea;
Jimeno, Aroa;
Serrano, Diego;
Calvo, Alfonso

Publication type:

Article

Effects of Cisplatin on the Radiation Response and DNA Damage Markers in Peripheral Blood Lymphocytes Ex Vivo.

Published in:

Cells (2073-4409), 2025, v. 14, n. 10, p. 682, doi. 10.3390/cells14100682

By:

Zahnreich, Sebastian;
Bhatti, Aisha;
Ahmad, Barea;
Drabke, Sophia;
Kaufmann, Justus;
Schmidberger, Heinz

Publication type:

Article

Mechanisms of DNA Damage Recognition by UDG and PARP1 in the Nucleosome.

Published in:

Biomolecules (2218-273X), 2025, v. 15, n. 5, p. 649, doi. 10.3390/biom15050649

By:

Ghediri, Safwen;
Sarma, Parvathy A. P.;
Saravanan, Vinnarasi;
Abbadie, Corinne;
Blossey, Ralf;
Cleri, Fabrizio

Publication type:

Article

Artesunate Enhances Sensitivity of Renal Cancer Cells to Sunitnib by Mediating Tripartite Motif Containing 24‐Induced Ubiquitination of Paired Box 6.

Published in:

Chemical Biology & Drug Design, 2025, v. 105, n. 5, p. 1, doi. 10.1111/cbdd.70116

By:

Cui, Zelin;
Wen, Jianhua;
Yang, Guanglin;
Wei, Liwei;
Chen, Hao;
Zhao, Qiyue;
Yang, Shubo;
Yu, Jiayin;
Huang, Yichen;
Tan, Shuting;
Mo, Qizhou;
Qin, Min;
Cheng, Jiwen

Publication type:

Article

Editor's Note to: "p53-Dependent and p53-Independent Induction of Insulin-Like Growth Factor Binding Protein-3 by Deoxyribonucleic Acid Damage and Hypoxia" Free.

Published in:: Journal of Clinical Endocrinology & Metabolism, 2025, v. 110, n. 6, p. e2105, doi. 10.1210/clinem/dgaf169
Publication type:: Article

Elevated nonhomologous end-joining by AATF enables efficient DNA damage repair and therapeutic resistance in glioblastoma.

Published in:

Nature Communications, 2025, v. 16, n. 1, p. 1, doi. 10.1038/s41467-025-60228-z

By:

Mi, Lanjuan;
Cai, Yan;
Qi, Ji;
Chen, Lishu;
Li, Yuanyuan;
Zhang, Songyang;
Ran, Haowen;
Qi, Qinghui;
Zhang, Cheng;
Wu, Huiran;
Cao, Shuailiang;
Huang, Haohao;
Xiao, Dake;
Wang, Xinzheng;
Li, Bohan;
Xie, Jiong;
Li, Fangye;
Han, Qiuying;
Wu, Qiulian;
Li, Tao

Publication type:

Article

Short Tandem Repeat (STR) Somatic Mutation in Non-Melanoma Skin Cancer (NMSC): Association with Transcriptomic Profile and Potential Implications for Therapy.

Published in:

Cancers, 2025, v. 17, n. 10, p. 1669, doi. 10.3390/cancers17101669

By:

Kibriya, Muhammad G.;
Almazan, Armando;
Argos, Maria;
Islam, Tariqul;
Shea, Christopher R.;
Ahsan, Habibul;
Jasmine, Farzana

Publication type:

Article

Programmed Death-1 Ligand 1 Domain Organization, Signaling Motifs, and Interactors in Cancer Immunotherapy.

Published in:

Cancers, 2025, v. 17, n. 10, p. 1635, doi. 10.3390/cancers17101635

By:

Escors, David;
Chocarro, Luisa;
Echaide, Miriam;
Rodriguez-Neira, Claudia;
Vilaplana, Borja;
Kochan, Grazyna

Publication type:

Article

The Use of Mutational Signatures to Decipher the Inter-Relationship of Reactive Oxygen Species with Homologous Recombination and Non-Homologous End-Joining Deficiencies as Well as Their Effects on APOBEC Mutagenesis in Breast Cancer.

Published in:

Cancers, 2025, v. 17, n. 10, p. 1627, doi. 10.3390/cancers17101627

By:

Farmanbar, Amir;
Kneller, Robert;
Firouzi, Sanaz

Publication type:

Article

Therapeutic Potential of Quadrigemine I Against Lymphoma: Mechanistic Insights from Cell Lines and Xenograft Models Demonstrating DNA Damage, Oxidative Stress, and Pathway Regulation.

Published in:

International Journal of Molecular Sciences, 2025, v. 26, n. 10, p. 4848, doi. 10.3390/ijms26104848

By:

Pu, Junmei;
Shi, Wenfeng;
Cui, Jiabao;
Yang, Hui;
Cao, Jianxin;
Liu, Yaping;
Xiao, Shanshan;
Cheng, Guiguang

Publication type:

Article

Different Mechanisms in Doxorubicin-Induced Neurotoxicity: Impact of BRCA Mutations.

Published in:

International Journal of Molecular Sciences, 2025, v. 26, n. 10, p. 4736, doi. 10.3390/ijms26104736

By:

Bhatt, Kriti S.;
Singh, Aman;
Marwaha, Gursharan S.;
Ravendranathan, Naresh;
Sandhu, Inderbir S.;
Kim, Kristen;
Singh, Eesha;
Frisbee, Jefferson C.;
Singh, Krishna K.

Publication type:

Article

Genotoxicity test of Ganoderma lucidum using a microbial mutagenicity test (Ames test).

Published in:

New Food Industry, 2025, v. 67, n. 5, p. 275

By:

Yeunhwa Gu;
Takenori Yamashita;
Tota Inoue

Publication type:

Article

PURPL Represses Radiation‐Induced Apoptosis to Promote Radioresistance in Cutaneous Melanoma by Direct Interfering With BID Cleavage.

Published in:

Pigment Cell & Melanoma Research, 2025, v. 38, n. 3, p. 1, doi. 10.1111/pcmr.70018

By:

Li, Xue;
Han, Shuo;
Liang, Xiaoting;
Liu, Jieyu;
Wang, Ke;
Jin, Yi;
Zhang, Chunting;
Xu, Minna;
Liu, Jiabin;
Ma, Li;
Zhou, Liang

Publication type:

Article

Tobacco-Free Cigarettes as Hazardous as Regular Tobacco Cigarettes.

Published in:: RT: The Journal for Respiratory Care Practitioners, 2010, v. 23, n. 6, p. 35
Publication type:: Article

Capturing snapshots of APE1 processing DNA damage.

Published in:

Nature Structural & Molecular Biology, 2015, v. 22, n. 11, p. 924, doi. 10.1038/nsmb.3105

By:

Freudenthal, Bret D;
Beard, William A;
Cuneo, Matthew J;
Dyrkheeva, Nadezhda S;
Wilson, Samuel H

Publication type:

Article

Complex interactions between the DNA-damage response and mammalian telomeres.

Published in:

Nature Structural & Molecular Biology, 2015, v. 22, n. 11, p. 859, doi. 10.1038/nsmb.3092

By:

Arnoult, Nausica;
Karlseder, Jan

Publication type:

Article

Unraveling the ends.

Published in:: Nature Structural & Molecular Biology, 2015, v. 22, n. 11, p. 843, doi. 10.1038/nsmb.3123
Publication type:: Article

PAR and the organization of the DNA damage response.

Published in:

Nature Structural & Molecular Biology, 2015, v. 22, n. 9, p. 655, doi. 10.1038/nsmb.3089

By:

Chen, Inês

Publication type:

Article

Recruitment and activation of the ATM kinase in the absence of DNA-damage sensors.

Published in:

Nature Structural & Molecular Biology, 2015, v. 22, n. 9, p. 736, doi. 10.1038/nsmb.3072

By:

Hartlerode, Andrea J;
Morgan, Mary J;
Wu, Yipin;
Buis, Jeffrey;
Ferguson, David O

Publication type:

Article

Notch is a direct negative regulator of the DNA-damage response.

Published in:

Nature Structural & Molecular Biology, 2015, v. 22, n. 5, p. 417, doi. 10.1038/nsmb.3013

By:

Vermezovic, Jelena;
Adamowicz, Marek;
Santarpia, Libero;
Rustighi, Alessandra;
Forcato, Mattia;
Lucano, Caterina;
Massimiliano, Lucia;
Costanzo, Vincenzo;
Bicciato, Silvio;
Del Sal, Giannino;
d'Adda di Fagagna, Fabrizio

Publication type:

Article

Human DNA polymerase θ grasps the primer terminus to mediate DNA repair.

Published in:

Nature Structural & Molecular Biology, 2015, v. 22, n. 4, p. 304, doi. 10.1038/nsmb.2993

By:

Zahn, Karl E;
Averill, April M;
Aller, Pierre;
Wood, Richard D;
Doublié, Sylvie

Publication type:

Article

SET-ting the stage for DNA repair.

Published in:

Nature Structural & Molecular Biology, 2014, v. 21, n. 8, p. 655, doi. 10.1038/nsmb.2866

By:

Jha, Deepak K;
Pfister, Sophia X;
Humphrey, Timothy C;
Strahl, Brian D

Publication type:

Article

Let it go: how to deal with a breakup in mitosis.

Published in:

Nature Structural & Molecular Biology, 2014, v. 21, n. 5, p. 433, doi. 10.1038/nsmb.2825

By:

Denchi, Eros Lazzerini;
Li, Julia

Publication type:

Article

JMJD1C demethylates MDC1 to regulate the RNF8 and BRCA1-mediated chromatin response to DNA breaks.

Published in:

Nature Structural & Molecular Biology, 2013, v. 20, n. 12, p. 1425, doi. 10.1038/nsmb.2702

By:

Watanabe, Sugiko;
Watanabe, Kenji;
Akimov, Vyacheslav;
Bartkova, Jirina;
Blagoev, Blagoy;
Lukas, Jiri;
Bartek, Jiri

Publication type:

Article

Repriming of DNA synthesis at stalled replication forks by human PrimPol.

Published in:

Nature Structural & Molecular Biology, 2013, v. 20, n. 12, p. 1383, doi. 10.1038/nsmb.2719

By:

Mourón, Silvana;
Rodriguez-Acebes, Sara;
Martínez-Jiménez, María I;
García-Gómez, Sara;
Chocrón, Sandra;
Blanco, Luis;
Méndez, Juan

Publication type:

Article

A mediator methylation mystery: JMJD1C demethylates MDC1 to regulate DNA repair.

Published in:

Nature Structural & Molecular Biology, 2013, v. 20, n. 12, p. 1346, doi. 10.1038/nsmb.2729

By:

Lu, Jian;
Matunis, Michael J

Publication type:

Article

Sensing KATastrophe.

Published in:

Nature Structural & Molecular Biology, 2013, v. 20, n. 7, p. 775, doi. 10.1038/nsmb.2633

By:

Moorefield, Beth

Publication type:

Article

A family of macrodomain proteins reverses cellular mono-ADP-ribosylation.

Published in:

Nature Structural & Molecular Biology, 2013, v. 20, n. 4, p. 508, doi. 10.1038/nsmb.2523

By:

Jankevicius, Gytis;
Hassler, Markus;
Golia, Barbara;
Rybin, Vladimir;
Zacharias, Martin;
Timinszky, Gyula;
Ladurner, Andreas G

Publication type:

Article

Sequential primed kinases create a damage-responsive phosphodegron on Eco1.

Published in:

Nature Structural & Molecular Biology, 2013, v. 20, n. 2, p. 194, doi. 10.1038/nsmb.2478

By:

Lyons, Nicholas A;
Fonslow, Bryan R;
Diedrich, Jolene K;
Yates, John R;
Morgan, David O

Publication type:

Article

Molecular basis for H3K36me3 recognition by the Tudor domain of PHF1.

Published in:

Nature Structural & Molecular Biology, 2012, v. 19, n. 12, p. 1266, doi. 10.1038/nsmb.2435

By:

Musselman, Catherine A;
Avvakumov, Nikita;
Watanabe, Reiko;
Abraham, Christopher G;
Lalonde, Marie-Eve;
Hong, Zehui;
Allen, Christopher;
Roy, Siddhartha;
Nuñez, James K;
Nickoloff, Jac;
Kulesza, Caroline A;
Yasui, Akira;
Côté, Jacques;
Kutateladze, Tatiana G

Publication type:

Article

H3K36me3 key to Polycomb-mediated gene silencing in lineage specification.

Published in:

Nature Structural & Molecular Biology, 2012, v. 19, n. 12, p. 1214, doi. 10.1038/nsmb.2458

By:

Abed, Jumana AlHaj;
Jones, Richard S.

Publication type:

Article

DVC1 (C1orf124) recruits the p97 protein segregase to sites of DNA damage.

Published in:

Nature Structural & Molecular Biology, 2012, v. 19, n. 11, p. 1093, doi. 10.1038/nsmb.2394

By:

Davis, Emily J;
Lachaud, Christophe;
Appleton, Paul;
Macartney, Thomas J;
Näthke, Inke;
Rouse, John

Publication type:

Article

DVC1 (C1orf124) is a DNA damage-targeting p97 adaptor that promotes ubiquitin-dependent responses to replication blocks.

Published in:

Nature Structural & Molecular Biology, 2012, v. 19, n. 11, p. 1084, doi. 10.1038/nsmb.2395

By:

Mosbech, Anna;
Gibbs-Seymour, Ian;
Kagias, Konstantinos;
Thorslund, Tina;
Beli, Petra;
Povlsen, Lou;
Nielsen, Sofie Vincents;
Smedegaard, Stine;
Sedgwick, Garry;
Lukas, Claudia;
Hartmann-Petersen, Rasmus;
Lukas, Jiri;
Choudhary, Chunaram;
Pocock, Roger;
Bekker-Jensen, Simon;
Mailand, Niels

Publication type:

Article

The zinc-finger domains of PARP1 cooperate to recognize DNA strand breaks.

Published in:

Nature Structural & Molecular Biology, 2012, v. 19, n. 7, p. 685, doi. 10.1038/nsmb.2335

By:

Ali, Ammar A E;
Timinszky, Gyula;
Arribas-Bosacoma, Raquel;
Kozlowski, Marek;
Hassa, Paul O;
Hassler, Markus;
Ladurner, Andreas G;
Pearl, Laurence H;
Oliver, Antony W

Publication type:

Article

Structure of Mre11-Nbs1 complex yields insights into ataxia-telangiectasia-like disease mutations and DNA damage signaling.

Published in:

Nature Structural & Molecular Biology, 2012, v. 19, n. 7, p. 693, doi. 10.1038/nsmb.2323

By:

Schiller, Christian B;
Lammens, Katja;
Guerini, Ilaria;
Coordes, Britta;
Feldmann, Heidi;
Schlauderer, Florian;
Möckel, Carolin;
Schele, Alexandra;
Strässer, Katja;
Jackson, Stephen P;
Hopfner, Karl-Peter

Publication type:

Article

Structural basis for cisplatin DNA damage tolerance by human polymerase ? during cancer chemotherapy.

Published in:

Nature Structural & Molecular Biology, 2012, v. 19, n. 6, p. 628, doi. 10.1038/nsmb.2295

By:

Ummat, Ajay;
Rechkoblit, Olga;
Jain, Rinku;
Roy Choudhury, Jayati;
Johnson, Robert E;
Silverstein, Timothy D;
Buku, Angeliki;
Lone, Samer;
Prakash, Louise;
Prakash, Satya;
Aggarwal, Aneel K

Publication type:

Article

Small RNA-mediated DNA repair.

Published in:

Nature Structural & Molecular Biology, 2012, v. 19, n. 5, p. 470, doi. 10.1038/nsmb.2298

By:

Mason, Steve

Publication type:

Article

Structure and mechanism of the UvrA-UvrB DNA damage sensor.

Published in:

Nature Structural & Molecular Biology, 2012, v. 19, n. 3, p. 291, doi. 10.1038/nsmb.2240

By:

Pakotiprapha, Danaya;
Samuels, Martin;
Shen, Koning;
Hu, Johnny H;
Jeruzalmi, David

Publication type:

Article

A telomere-dependent DNA damage checkpoint induced by prolonged mitotic arrest.

Published in:

Nature Structural & Molecular Biology, 2012, v. 19, n. 4, p. 387, doi. 10.1038/nsmb.2245

By:

Hayashi, Makoto T;
Cesare, Anthony J;
Fitzpatrick, James A J;
Lazzerini-Denchi, Eros;
Karlseder, Jan

Publication type:

Article

Anticheckpoint pathways at telomeres in yeast.

Published in:

Nature Structural & Molecular Biology, 2012, v. 19, n. 3, p. 307, doi. 10.1038/nsmb.2225

By:

Ribeyre, Cyril;
Shore, David

Publication type:

Article

The E3 ligase RNF8 regulates KU80 removal and NHEJ repair.

Published in:

Nature Structural & Molecular Biology, 2012, v. 19, n. 2, p. 201, doi. 10.1038/nsmb.2211

By:

Feng, Lin;
Chen, Junjie

Publication type:

Article

Formaldehyde catabolism is essential in cells deficient for the Fanconi anemia DNA-repair pathway.

Published in:

Nature Structural & Molecular Biology, 2011, v. 18, n. 12, p. 1432, doi. 10.1038/nsmb.2173

By:

Rosado, Ivan V;
Langevin, Frédéric;
Crossan, Gerry P;
Takata, Minoru;
Patel, Ketan J

Publication type:

Article

Tel1<sup>ATM</sup> and Rad3<sup>ATR</sup> kinases promote Ccq1-Est1 interaction to maintain telomeres in fission yeast.

Published in:

Nature Structural & Molecular Biology, 2011, v. 18, n. 12, p. 1408, doi. 10.1038/nsmb.2187

By:

Moser, Bettina A;
Chang, Ya-Ting;
Kosti, Jorgena;
Nakamura, Toru M

Publication type:

Article

The AAA-ATPase VCP/p97 promotes 53BP1 recruitment by removing L3MBTL1 from DNA double-strand breaks.

Published in:

Nature Structural & Molecular Biology, 2011, v. 18, n. 12, p. 1345, doi. 10.1038/nsmb.2188

By:

Acs, Klara;
Luijsterburg, Martijn S;
Ackermann, Leena;
Salomons, Florian A;
Hoppe, Thorsten;
Dantuma, Nico P

Publication type:

Article

The E3 ubiquitin ligase Rnf8 stabilizes Tpp1 to promote telomere end protection.

Published in:

Nature Structural & Molecular Biology, 2011, v. 18, n. 12, p. 1400, doi. 10.1038/nsmb.2172

By:

Rai, Rekha;
Li, Ju-Mei;
Zheng, Hong;
Lok, Gabriel Tsz-Mei;
Deng, Yu;
Huen, Michael S-Y;
Chen, Junjie;
Jin, Jianping;
Chang, Sandy

Publication type:

Article

Structure of an aprataxin-DNA complex with insights into AOA1 neurodegenerative disease.

Published in:

Nature Structural & Molecular Biology, 2011, v. 18, n. 11, p. 1189, doi. 10.1038/nsmb.2146

By:

Tumbale, Percy;
Appel, C Denise;
Kraehenbuehl, Rolf;
Robertson, Patrick D;
Williams, Jessica S;
Krahn, Joe;
Ahel, Ivan;
Williams, R Scott

Publication type:

Article

Chfr and RNF8 synergistically regulate ATM activation.

Published in:

Nature Structural & Molecular Biology, 2011, v. 18, n. 7, p. 761, doi. 10.1038/nsmb.2078

By:

Jiaxue Wu;
Yibin Chen;
Lin-Yu Lu;
Yipin Wu;
Paulsen, Michelle T.;
Ljungman, Mats;
Ferguson, David O.;
Xiaochun Yu

Publication type:

Article

Unraveling the mechanism of BRCA2 in homologous recombination.

Published in:

Nature Structural & Molecular Biology, 2011, v. 18, n. 7, p. 748, doi. 10.1038/nsmb.2096

By:

Holloman, William K.

Publication type:

Article