The effect of polymer system on polymer-stabilized blue phase liquid crystals (PSBPLCs) is investigated. The experimental results indicate that the electro-optic properties of PSBPLC are affected by the interface energy between the liquid crystal molecules and polymer system. As the anchoring energy of polymer system decreases, the driving voltage will decrease, but hysteresis and residual birefringence will increase. In addition, if the anchoring energy is less than a threshold value, the BPLC cannot be stabilized well by polymer network.