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- Title
The role of calcium in the pharmacology of mania
- Authors
Dinan, Timothy G.; Elphick, Martin; Sharp, Trevor
- Abstract
Episodes of mania in bipolar affective disorder patients are associated with a decrease in cerebrospinal fluid calcium. A reduction in extracellular calcium in most neurones leads to a decrease in calcium‐activated potassium conductance mechanisms. Such mechanisms help govern the rate of action potential generation by neurones, and thus the rate of information processing. The dopamine hypothesis of neuroleptic action cannot explain the antimanic actions of lithium, calcium antagonists or carbamazepine. This paper proposes a common mechanism of action for such substances — namely, an action on calcium‐activated potassium conductances.
- Publication
Human Psychopharmacology: Clinical and Experimental, 1989, Vol 4, Issue 2, p139
- ISSN
0885-6222
- DOI
10.1002/hup.470040210