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- Title
Polymorphism in alpha 2A adrenergic receptor gene is associated with sialorrhea in schizophrenia patients on clozapine treatment.
- Authors
Solismaa, Anssi; Kampman, Olli; Seppälä, Niko; Viikki, Merja; Mäkelä, Kari-Matti; Mononen, Nina; Lehtimäki, Terho; Leinonen, Esa
- Abstract
Clozapine-induced sialorrhea (CIS) is a common, inconvenient and socially stigmatizing adverse effect. The pathophysiology of CIS may be related to the effect of clozapine on the muscarinic and adrenergic receptors as well as the disruption of the circadian rhythms. The aim of this study was to find out if polymorphisms in muscarinic M1 and M3 receptor genes (CHRM1 and CHRM3), adrenoceptor alpha 2A gene (ADRA2A) or clock circadian regulator gene (CLOCK) are associated with CIS.
- Publication
Human psychopharmacology, 2014, Vol 29, Issue 4, p336
- ISSN
1099-1077
- Publication type
Journal Article
- DOI
10.1002/hup.2408