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- Title
The added value of karyotype in predicting the need for therapy in chronic lymphocytic leukemia with 13q deletion.
- Authors
Martines, Annalisa; Grassi, Angela; Visentin, Andrea; Facco, Monica; Nalio, Silvia; Sacchetto, Valeria; Pagnin, Elisa; Cellini, Alessandro; Bertorelle, Roberta; Trentin, Livio; Bonaldi, Laura
- Abstract
This article, published in Hematological Oncology, explores the role of karyotype in predicting the need for therapy in chronic lymphocytic leukemia (CLL) with 13q deletion. The study analyzed the karyotype of 106 CLL cases with isolated 13q deletion and found that the presence of additional chromosomal abnormalities increased the risk of requiring treatment. The study also confirmed the predictive role of immunoglobulin heavy variable (IGHV) gene mutation status in therapy requirement. The authors propose a classification system based on both IGHV status and karyotype to better predict the need for therapy in low-risk CLL patients.
- Subjects
CHRONIC lymphocytic leukemia; KARYOTYPES; CHRONIC leukemia; HEMATOLOGICAL oncology; GENETIC mutation
- Publication
Hematological Oncology, 2023, Vol 41, Issue 5, p951
- ISSN
0278-0232
- Publication type
Academic Journal
- DOI
10.1002/hon.3201