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- Title
Enhancing T‐cell responses to GCB‐like lymphomas with immune‐checkpoint‐blockade‐based therapies.
- Authors
Serganova, I.; Bucktrout, R.; Isshiki, Y.; Sarapulov, A.; Santella, A.; Rodriguez, M.; Chakraborty, S.; Brunschvig, S.; Qualls, D.; Vardhana, S.; Lesokhin, A.; Melnick, A.; Beguelin, W.; Zappasodi, R.
- Abstract
Of note, normal B and/or GCB cells in lymphoma-bearing vs. control mice also downregulated MHC-II, pointing to aberrant B:CD4 SP sp T-cell interactions overall. B Introduction: b Germinal center B-cell(GCB)-like diffuse large B-cell lymphomas and follicular lymphomas resemble GCB cells, which are normally controlled by CD4 SP sp T follicular helper (Tfh) cells. Enhancing T-cell responses to GCB-like lymphomas with immune-checkpoint-blockade-based therapies.
- Subjects
T cells; LYMPHOMAS; CYTOTOXIC T cells; REGULATORY T cells
- Publication
Hematological Oncology, 2023, Vol 41, p280
- ISSN
0278-0232
- Publication type
Academic Journal
- DOI
10.1002/hon.3164_192