Title: Cytotoxic Diterpenoids from the Stem Bark of Annona squamosa L.
Authors: Zhou, Chang-Xin; Sun, Li-Rui; Feng, Feng; Mo, Jian-Xia; Zhu, Hong; Yang, Bo; He, Qiao-Jun; Gan, Li-She
Abstract: Three new ent-kaurane diterpenoids, (4 α)-19-nor- ent-kaurane-4,16,17-triol ( 1), (4 α,16 α)-17-(acetyloxy)-19-nor- ent-kaurane-4,16 -diol ( 2), and 17-hydroxy- ent-kaur-15-en-19-al ( 3), together with 11 known compounds, were isolated from the stem bark of Annona squamosa L. The structures of 1- 3 were identified by analysis of their spectroscopic data. All compounds were evaluated for cytotoxic activity against human lung cancer (95-D) and ovarian cancer (A2780) cell lines, and compounds 3, 5, 7, 11- 14 exhibited promising antiproliferative activities with IC50 values ranging from 0.38 to 34.66 μ M.
Subjects: DITERPENES; BARK; ANNONA; LUNG cancer; OVARIAN cancer
Publication: Helvetica Chimica Acta, 2013, Vol 96, Issue 4, p656
ISSN: 0018-019X
Publication type: Academic Journal
DOI: 10.1002/hlca.201200249

Cytotoxic Diterpenoids from the Stem Bark of Annona squamosa L.

Zhou, Chang-Xin; Sun, Li-Rui; Feng, Feng; Mo, Jian-Xia; Zhu, Hong; Yang, Bo; He, Qiao-Jun; Gan, Li-She